Caenorhabditis Testing Program Data Coordinating Center

秀丽隐杆线虫检测项目数据协调中心

• 批准号: 10670378
• 负责人: Patrick C. Phillips
• 金额: $ 29.03万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-05 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670378
• 关键词: Accountability; Achievement; Adopted; Age; Aging; American; Animal Model; Back; Biological Assay; Biological Models; Biology of Aging; Caenorhabditis; Caenorhabditis elegans; Caregivers; Chemicals; Chronic Disease; Chronology; Clinical Sciences; Collection; Communities; Computer software; Data; Data Analyses; Data Coordinating Center; Databases; Dementia; Deterioration; Development; Diabetes Mellitus; Disease; Disease susceptibility; Economics; Educational Materials; Elderly; Elements; Genes; Genetic; Genetic Drift; Genetic Heterogeneity; Goals; Health; Healthcare Systems; Heart; Heterogeneity; High-Throughput RNA Sequencing; Human; Impaired cognition; Internet; Intervention; Laboratories; Link; Longevity; Malignant Neoplasms; Maps; Medical Research; Modeling; Mus; Nematoda; Neurodegenerative Disorders; Outcome; Pathway interactions; Population; Population Heterogeneity; Price; Privatization; Process; Proportional Hazards Models; Publishing; Quality of life; Recommendation; Records; Reproducibility; Research; Research Personnel; Resistance; Risk Factors; Science; Site; Societies; Standardization; Stress; Structure; Students; System; Systems Analysis; Technology; Testing; Translating; Validation; Variant; Virus Diseases; Work; age related; bioinformatics pipeline; community setting; data centers; data dissemination; data portal; data repository; database schema; design; efficacy testing; genome editing; hazard; healthspan; healthy aging; human old age (65+); improved; innovation; novel; novel strategies; open source; pharmacologic; pre-clinical; programs; quality assurance; repository; success; therapy development; tool; transcriptome sequencing; transcriptomics; user-friendly; web portal; web site; whole genome

Caenorhabditis Intervention Testing Program Data Coordinating Center—Project Summary Health challenges linked to human aging take a tremendous toll on society. Physical and cognitive decline limit the quality of life for the elderly and their caregivers. Aging is the major risk factor for, and possible cause of, cancer, diabetes, and neurodegenerative disease. Without question, the promotion of healthy aging with extended resistance to decline and disease should be a major objective of current medical research. Fortunately, tremendous progress has been made in the biology of aging field and the science is poised to be translated into preclinical and clinical science. Simple animal models such as the nematode Caenorhabditis elegans have been at the heart of this success. Many genes and chemical compound interventions that modulate aging processes are likely to act similarly in humans. The goal of the proposed work is to continue, and expand, efforts of a co-operative scientific group involving three closely interacting laboratories who coordinately test pharmacological interventions for their ability to extend healthy aging and promote longevity in nematodes. A specific emphasis of this integrated super-group is to test promising compound on a collection of natural variants of the Caenorhabditis genus, which together represent the extensive genetic heterogeneity in the human population. The idea is that treatments that confer positive outcomes across a diverse population will have an increased chance of being effective in humans. The Data Coordinating Center supports work at all three project sites by creating a centralized data repository (currently 400,000 longevity records), uniform analytical pipelines, and public-facing repositories and websites. The emphasis of this specific proposal is to (1) maintain and enhance a central data repository to support the work of all CITP labs, (2) generate standardized open-source analytical framework for all CITP data analysis, (3) develop comprehensive database and analytical framework for novel hallmarks of aging and healthspan, and (4) develop a public and private online portal of lifespan and healthspan data. Overall, we will participate in a unique team project that has the power to define pharmacological interventions that robustly promote strong healthspan across a varied population, with implications for development of therapies that promote healthy human aging.

隐杆线虫干预试验计划数据协调中心-项目摘要 与人类老龄化相关的健康挑战给社会带来巨大损失。身体和认知能力下降极限 老年人及其照顾者的生活质量。衰老是主要的风险因素，也是可能的原因， 癌症、糖尿病和神经退行性疾病。毫无疑问，促进健康老龄化， 对衰退和疾病的长期抵抗力应该是当前医学研究的一个主要目标。 幸运的是，衰老生物学领域已经取得了巨大进展，并且这门科学即将成为 转化为临床前和临床科学。 简单的动物模型，如秀丽隐杆线虫，是这一成功的核心。 许多调节衰老过程的基因和化学化合物干预可能在衰老过程中起类似的作用。 人类拟议工作的目标是继续并扩大合作科学小组的努力 涉及三个密切互动的实验室，他们协调测试药物干预， 能够延长线虫的健康衰老和促进长寿。这一综合的具体重点 超级小组的任务是在一组小杆线虫属的天然变种上测试有希望的化合物， 它们共同代表了人类群体中广泛的遗传异质性。这个想法是 在不同人群中产生积极结果的治疗将有更大的机会 对人类有效。 数据协调中心通过创建一个集中的数据存储库来支持所有三个项目站点的工作 （目前有400，000条长寿记录），统一的分析管道，面向公众的存储库和网站。 这项具体建议的重点是（1）维持和加强中央数据库，以支持 所有CITP实验室的工作，（2）为所有CITP数据分析生成标准化开源分析框架， (3)为衰老和健康寿命的新标志建立全面的数据库和分析框架， 以及（4）开发寿命和健康寿命数据的公共和私人在线门户网站。 总的来说，我们将参与一个独特的团队项目，该项目具有定义药理干预的能力 这有力地促进了不同人群的健康，对发展产生了影响， 促进人类健康衰老的疗法。

项目成果

Genetic diversity estimates for the Caenorhabditis Intervention Testing Program screening panel.

• DOI: 10.17912/micropub.biology.000518
• 发表时间: 2022
• 期刊: microPublication biology
• 作者: Teterina AA;Coleman-Hulbert AL;Banse SA;Willis JH;Perez VI;Lithgow GJ;Driscoll M;Phillips PC
• 通讯作者: Phillips PC

A simplified design for the C. elegans lifespan machine.

• DOI: 10.14440/jbm.2020.332
• 发表时间: 2020
• 期刊: Journal of biological methods
• 作者: Abbott M;Banse SA;Melentijevic I;Jarrett CM;Ange JS;Sedore CA;Falkowski R;Blue BW;Coleman-Hulbert AL;Johnson E;Guo M;Lithgow GJ;Phillips PC;Driscoll M
• 通讯作者: Driscoll M

Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes.

二甲双胍治疗多种细胞炎，揭示了遗传背景在寿命和健康范围扩展结果中的重要性。

• DOI: 10.1111/acel.13488
• 发表时间: 2022-01
• 期刊: Aging cell
• 影响因子: 7.8
• 作者: Onken B;Sedore CA;Coleman-Hulbert AL;Hall D;Johnson E;Jones EG;Banse SA;Huynh P;Guo S;Xue J;Chen E;Harinath G;Foulger AC;Chao EA;Hope J;Bhaumik D;Plummer T;Inman D;Morshead M;Guo M;Lithgow GJ;Phillips PC;Driscoll M
• 通讯作者: Driscoll M

Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes.

• DOI: 10.17912/micropub.biology.000131
• 发表时间: 2019-01-01
• 期刊: microPublication biology
• 作者: Coleman-Hulbert, Anna L;Johnson, Erik;Phillips, Patrick C
• 通讯作者: Phillips, Patrick C

Caenorhabditis Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes.

线虫干预测试计划：法尼醇 X 受体激动剂奥贝胆酸不能显着延长线虫的寿命。

• DOI: 10.17912/micropub.biology.000257
• 发表时间: 2020
• 期刊: microPublication biology
• 作者: Morshead,MackenzieL;Sedore,ChristineA;Jones,EGrace;Hall,David;Plummer,WTodd;Garrett,Theo;Lucanic,Mark;Guo,Max;Driscoll,Monica;Phillips,PatrickC;Lithgow,Gordon
• 通讯作者: Lithgow,Gordon