Contributions of distinct auditory pathways to sound-driven choices

不同听觉通路对声音驱动选择的贡献

• 批准号: 10597329
• 负责人: Santiago Jaramillo
• 金额: $ 14.46万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10597329
• 关键词: Acoustics; Action Research; Address; Affect; Attention; Auditory; Auditory Perceptual Disorders; Auditory area; Award; Basal Ganglia; Behavior; Behavioral; Brain; Child; Code; Cognition; Cognitive; Complex; Comprehension; Corpus striatum structure; Data; Development; Diagnosis; Diagnostic; Discrimination; Disease; Foundations; Frequencies; Goals; Human; Impairment; Injury; Knowledge; Learning; Link; Maps; Measurement; Measures; Modeling; Monitor; Motor; Mus; Nervous system structure; Neural Network Simulation; Neural Pathways; Neurons; Outcome; Pathway interactions; Performance; Physiological; Play; Process; Regulation; Research; Role; Sensory; Specificity; Structure; System; Tail; Techniques; Testing; Thalamic structure; Theoretical model; Therapeutic; Training; Trauma; Work; auditory pathway; auditory thalamus; awake; behavioral response; experience; experimental study; flexibility; improved; insight; motor behavior; normal hearing; novel; relating to nervous system; response; sound; sound frequency; theories

PROJECT SUMMARY/ABSTRACT Effective interpretation of sound requires discriminating acoustic features and linking them to appropriate behavioral responses depending on past experience. Much remains unknown, however, about the roles that different neural pathways play in representing, learning, and performing these associations. As a step toward addressing the long-term goal of understanding how the nervous system flexibly links sounds to actions, this research will study the contributions of the multiple auditory pathways that target the striatum, the main input stage of the basal ganglia and a key structure in the regulation of motor behavior. Specifically, the project will focus on the flow of information from the auditory thalamus as well as primary and non-primary areas of the auditory cortex to the posterior tail of the striatum. The central hypothesis is that the various auditory cortical and thalamic pathways to the striatum all play distinct roles during learning and execution of sound-driven decisions. This work will consist of developing theoretical models of sound representation and learning in the multiple auditory pathways converging on the striatum, as well as carrying out experiments in mice trained to perform acoustic discrimination tasks in order to test and refine these models. These experiments will take advantage of novel techniques for reversible manipulation of specific neural pathways while monitoring large numbers of neurons simultaneously during behavior. The project is organized in three aims. The first aim is to determine the conditions in which auditory cortico-striatal and thalamo-striatal pathways play distinct roles during performance of sound-action association tasks. The second aim is to determine the roles of auditory cortical vs. thalamic pathways to the striatum during learning of these tasks. The third aim is to identify the acoustic features of natural sounds conveyed by distinct auditory cortical fields to the striatum. Together, these studies will reveal the relative contributions of distinct neural pathways to sound-driven behavior in the healthy brain, and they will provide insights into how auditory cognition can be affected by disease.

项目总结/摘要 有效地解释声音需要区分声学特征，并将它们与适当的 行为反应取决于过去的经验。然而，关于这些角色， 不同的神经通路在表现、学习和执行这些关联中发挥作用。作为 这是朝着理解神经系统如何灵活地连接的长期目标迈出的一步 声音动作，这项研究将研究的贡献，多个听觉通路的目标 纹状体是基底神经节的主要输入阶段，也是运动调节的关键结构 行为具体来说，该项目将集中在听觉丘脑的信息流 以及听觉皮层的初级和非初级区域到纹状体的后尾。 中心假设是，各种听觉皮层和丘脑通路的纹状体， 在学习和执行合理驱动的决策过程中发挥着独特的作用。这项工作将包括 发展多听觉通路中声音表征和学习的理论模型 集中在纹状体，以及进行实验的小鼠训练，以执行声学 识别任务，以测试和完善这些模型。这些实验将利用 新技术的可逆操纵特定的神经通路，同时监测大 神经元的数量在行为过程中。该项目有三个目标。第一个 目的是确定听觉皮质-纹状体和丘脑-纹状体通路发挥作用的条件， 在执行声音动作关联任务过程中的不同角色。第二个目标是确定 听觉皮层与丘脑通路在这些任务的学习过程中的作用。第三 目的是识别由不同的听觉皮层场传递的自然声音的声学特征， 纹状体总之，这些研究将揭示不同的神经通路对 声音驱动的行为在健康的大脑，他们将提供洞察如何听觉认知 可能会受到疾病的影响。

项目成果

Sound-Evoked Responses of Distinct Neuron Classes from the Tail of the Striatum.

纹状体尾部不同神经元类别的声音诱发反应。

• DOI: 10.1523/eneuro.0201-22.2022
• 发表时间: 2022
• 期刊: eNeuro
• 影响因子: 3.4
• 作者: Nardoci,MatthewB;Lakunina,AnnaA;Henderling,DevinC;Pedregon,JewlyssaC;Mohn,JenniferL;Jaramillo,Santiago
• 通讯作者: Jaramillo,Santiago