Contributions of distinct auditory pathways to sound-driven choices

不同听觉通路对声音驱动选择的贡献

• 批准号: 10597329
• 负责人: Santiago Jaramillo
• 金额: $ 14.46万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10597329
• 关键词: Acoustics; Action Research; Address; Affect; Attention; Auditory; Auditory Perceptual Disorders; Auditory area; Award; Basal Ganglia; Behavior; Behavioral; Brain; Child; Code; Cognition; Cognitive; Complex; Comprehension; Corpus striatum structure; Data; Development; Diagnosis; Diagnostic; Discrimination; Disease; Foundations; Frequencies; Goals; Human; Impairment; Injury; Knowledge; Learning; Link; Maps; Measurement; Measures; Modeling; Monitor; Motor; Mus; Nervous system structure; Neural Network Simulation; Neural Pathways; Neurons; Outcome; Pathway interactions; Performance; Physiological; Play; Process; Regulation; Research; Role; Sensory; Specificity; Structure; System; Tail; Techniques; Testing; Thalamic structure; Theoretical model; Therapeutic; Training; Trauma; Work; auditory pathway; auditory thalamus; awake; behavioral response; experience; experimental study; flexibility; improved; insight; motor behavior; normal hearing; novel; relating to nervous system; response; sound; sound frequency; theories

PROJECT SUMMARY/ABSTRACT Effective interpretation of sound requires discriminating acoustic features and linking them to appropriate behavioral responses depending on past experience. Much remains unknown, however, about the roles that different neural pathways play in representing, learning, and performing these associations. As a step toward addressing the long-term goal of understanding how the nervous system flexibly links sounds to actions, this research will study the contributions of the multiple auditory pathways that target the striatum, the main input stage of the basal ganglia and a key structure in the regulation of motor behavior. Specifically, the project will focus on the flow of information from the auditory thalamus as well as primary and non-primary areas of the auditory cortex to the posterior tail of the striatum. The central hypothesis is that the various auditory cortical and thalamic pathways to the striatum all play distinct roles during learning and execution of sound-driven decisions. This work will consist of developing theoretical models of sound representation and learning in the multiple auditory pathways converging on the striatum, as well as carrying out experiments in mice trained to perform acoustic discrimination tasks in order to test and refine these models. These experiments will take advantage of novel techniques for reversible manipulation of specific neural pathways while monitoring large numbers of neurons simultaneously during behavior. The project is organized in three aims. The first aim is to determine the conditions in which auditory cortico-striatal and thalamo-striatal pathways play distinct roles during performance of sound-action association tasks. The second aim is to determine the roles of auditory cortical vs. thalamic pathways to the striatum during learning of these tasks. The third aim is to identify the acoustic features of natural sounds conveyed by distinct auditory cortical fields to the striatum. Together, these studies will reveal the relative contributions of distinct neural pathways to sound-driven behavior in the healthy brain, and they will provide insights into how auditory cognition can be affected by disease.

项目摘要/摘要 有效的声音解释需要区分声学特征并将其链接到适当的 行为反应取决于过去的经验。然而，关于角色仍然未知 这种不同的神经通路在代表，学习和执行这些关联方面发挥了作用。作为 朝着解决理解神经系统如何相互联系的长期目标的一步 这项研究的声音将研究针对的多种听觉途径的贡献 纹状体，低音神经节的主要输入阶段和电动机调节的关键结构 行为。特定的项目将重点关注听觉丘脑的信息流 以及纹状体后尾的听觉皮层的主要和非主要区域。 中心假设是通往纹状体的各种听觉皮质和丘脑途径all 在学习和执行声音驱动决策过程中扮演着不同的角色。这项工作将包括 在多个听觉途径中开发声音表示和学习的理论模型 在纹状体上融合，并在训练有声音的小鼠中进行实验 歧视任务是为了测试和重新确定这些模型。这些实验将利用 在监测大型同时可逆操纵特定神经途径的新型技术 仅在行为过程中，神经元数量。该项目以三个目标组织。第一个 目的是确定听觉皮层纹状体和丘脑纹状体途径的条件 在声音发作协会任务的性能中，不同的作用。第二个目的是确定 在学习这些任务期间，听觉皮质与丘脑途径的作用。第三 目的是确定不同听觉皮质领域传达的自然声音的声学特征 纹状体。这些研究一起将揭示不同神经途径的相对贡献 健康大脑中的声音驱动行为，它们将提供有关听觉认知方式的见解 可能受疾病的影响。

项目成果

Sound-Evoked Responses of Distinct Neuron Classes from the Tail of the Striatum.

纹状体尾部不同神经元类别的声音诱发反应。

• DOI: 10.1523/eneuro.0201-22.2022
• 发表时间: 2022
• 期刊: eNeuro
• 影响因子: 3.4
• 作者: Nardoci,MatthewB;Lakunina,AnnaA;Henderling,DevinC;Pedregon,JewlyssaC;Mohn,JenniferL;Jaramillo,Santiago
• 通讯作者: Jaramillo,Santiago