Contribution of distinct auditory pathways to sound-driven choices.

不同的听觉通路对声音驱动的选择的贡献。

• 批准号: 9513291
• 负责人: Santiago Jaramillo
• 金额: $ 3.51万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9513291
• 关键词: Acoustics; Address; Affect; Anatomy; Animal Model; Attention; Auditory; Auditory Evoked Potentials; Auditory Perceptual Disorders; Auditory area; Basal Ganglia; Behavior; Cells; Child; Code; Cognition; Cognitive; Complex; Comprehension; Corpus striatum structure; Data; Decision Making; Development; Diagnosis; Diagnostic; Disease; Dorsal; Electrophysiology (science); Evaluation; Foundations; Frequencies; Genetic; Goals; Hearing; Human; Impairment; Injury; Investigation; Knowledge; Link; Methods; Movement; Mus; Nervous system structure; Neurons; Outcome; Output; Pathway interactions; Pattern; Population; Process; Research; Role; Sensory; Signal Transduction; Site; Stimulus; Study models; Testing; Thalamic structure; Therapeutic; Trauma; Work; auditory pathway; auditory thalamus; awake; base; behavior influence; behavioral response; cognitive process; flexibility; improved; innovation; insight; nerve supply; neuromechanism; novel; optogenetics; relating to nervous system; response; sensory stimulus; sound; sound frequency; tool

Project Summary/Abstract The long-term goal of this research is to identify the neural mechanisms by which attention and changes in context influence the interpretation of sounds. In its simplest form, sound interpretation requires linking acoustic signals to behavioral responses. The objective of this proposal is to de- termine the contribution of distinct auditory pathways to sound-driven choices. This research will employ the mouse as a model organism and use genetic tools to identify specific cell populations according to their projection patterns. The first aim will test whether auditory thalamic and cortical circuits provide distinct acoustic information to basal ganglia regions involved in action selection. The second aim will identify the acoustic features represented by neurons from distinct basal gan- glia pathways. The third aim will test whether these neurons represent the meaning of a stimulus in addition to its acoustic features. The proposal is innovative not only in its use of genetic tools for the characterization of auditory pathways, but also in its evaluation of the role of auditory thalamic outputs to the basal ganglia. Moreover, these studies will help establish the mouse as an effective model for the study of auditory cognition, opening new avenues for detailed investigation of the neural basis of sound-driven behaviors. The proposed research is significant because it addresses es- sential steps towards identifying neural sites where context and sensory information are integrated to achieve flexible decision-making. This knowledge will greatly advance understanding of the neu- ral mechanisms underlying sound interpretation, and provide insights into how auditory cognition is affected by disease.

项目摘要/摘要 这项研究的长期目标是确定关注和关注的神经机制 上下文影响声音的解释。以最简单的形式，声音解释 需要将声学信号与行为响应联系起来。该提议的目的是脱颖而出 终止不同听觉途径对声音驱动选择的贡献。这项研究会 使用鼠标作为模型生物，并使用遗传工具来识别特定的细胞种群 根据他们的投影模式。第一个目标将测试听觉的丘脑和皮质 电路为行动选择中涉及的基本神经节区域提供了不同的声学信息。 第二个目标将确定由不同巴萨gan-的神经元所代表的声学特征 胶质路径。第三个目标将测试这些神经元是否代表刺激的含义 除了其声学特征。该提案不仅在使用遗传工具方面具有创新性 听觉途径的表征，以及在评估听觉丘脑的作用时 输出到基底神经节。此外，这些研究将有助于确定鼠标有效 研究听觉认知的模型，开辟了新的途径，以详细研究 声音行为的神经基础。拟议的研究非常重要，因为它解决了ES- 识别上下文和感官信息集成的神经部位的感官步骤 实现灵活的决策。这些知识将大大提高人们对neu的理解 声音解释的基础机制，并提供有关听觉认知方式的见解 受疾病的影响。