Contribution of distinct auditory pathways to sound-driven choices.

不同的听觉通路对声音驱动的选择的贡献。

• 批准号: 9305048
• 负责人: Santiago Jaramillo
• 金额: $ 30.75万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9305048
• 关键词: Acoustics; Address; Affect; Anatomy; Animal Model; Attention; Auditory; Auditory Evoked Potentials; Auditory Perceptual Disorders; Auditory area; Basal Ganglia; Behavior; Cells; Child; Code; Cognition; Cognitive; Complex; Comprehension; Corpus striatum structure; Data; Decision Making; Development; Diagnosis; Diagnostic; Disease; Dorsal; Electrophysiology (science); Evaluation; Foundations; Frequencies; Genetic; Goals; Hearing; Human; Impairment; Injury; Investigation; Knowledge; Link; Methods; Movement; Mus; Nervous system structure; Neurons; Outcome; Output; Pathway interactions; Pattern; Population; Process; Research; Role; Sensory; Signal Transduction; Site; Stimulus; Study models; Testing; Thalamic structure; Therapeutic; Trauma; Work; auditory pathway; auditory thalamus; awake; base; behavior influence; behavioral response; cognitive process; flexibility; improved; innovation; insight; nerve supply; neuromechanism; novel; optogenetics; relating to nervous system; response; sensory stimulus; sound; sound frequency; tool

Project Summary/Abstract The long-term goal of this research is to identify the neural mechanisms by which attention and changes in context influence the interpretation of sounds. In its simplest form, sound interpretation requires linking acoustic signals to behavioral responses. The objective of this proposal is to de- termine the contribution of distinct auditory pathways to sound-driven choices. This research will employ the mouse as a model organism and use genetic tools to identify specific cell populations according to their projection patterns. The first aim will test whether auditory thalamic and cortical circuits provide distinct acoustic information to basal ganglia regions involved in action selection. The second aim will identify the acoustic features represented by neurons from distinct basal gan- glia pathways. The third aim will test whether these neurons represent the meaning of a stimulus in addition to its acoustic features. The proposal is innovative not only in its use of genetic tools for the characterization of auditory pathways, but also in its evaluation of the role of auditory thalamic outputs to the basal ganglia. Moreover, these studies will help establish the mouse as an effective model for the study of auditory cognition, opening new avenues for detailed investigation of the neural basis of sound-driven behaviors. The proposed research is significant because it addresses es- sential steps towards identifying neural sites where context and sensory information are integrated to achieve flexible decision-making. This knowledge will greatly advance understanding of the neu- ral mechanisms underlying sound interpretation, and provide insights into how auditory cognition is affected by disease.

项目摘要/摘要 这项研究的长期目标是确定注意力和 fl中语境的变化影响了对声音的解释。在其最简单的形式下，声音解释 需要将声音信号与行为反应联系起来。这项建议的目的是要消除- 终止不同听觉通路对声音驱动选择的贡献。这项研究将 以小鼠为模式生物，利用基因工具鉴定特定的fic细胞群 根据它们的投影模式。fi的第一个目标将测试听觉丘脑和大脑皮层 回路向参与动作选择的基底节区域提供不同的声学信息。 第二个目标将识别来自不同基底GaN的神经元代表的声学特征。 神经胶质细胞的通路。第三个目标将测试这些神经元是否代表刺激的意义 除了它的声学特性之外。这项提议不仅在使用遗传工具方面具有创新性 听觉通路的表征，也是在评价其在听觉丘脑中的作用 输出到基底节。此外，这些研究将有助于将小鼠作为一种有效的 听觉认知研究模型，开辟了详细研究听觉认知的新途径 声音驱动行为的神经基础。这项拟议的研究之所以意义重大，是因为它涉及的是ES-fi。 识别整合了上下文和感觉信息的神经部位的合理步骤 以实现fl的灵活决策。这一知识将极大地促进对中子星的理解。 声音解释背后的RAR机制，并提供关于听觉认知如何 会受到疾病的影响。