Contribution of distinct auditory pathways to sound-driven choices.

不同的听觉通路对声音驱动的选择的贡献。

• 批准号: 9305048
• 负责人: Santiago Jaramillo
• 金额: $ 30.75万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9305048
• 关键词: Acoustics; Address; Affect; Anatomy; Animal Model; Attention; Auditory; Auditory Evoked Potentials; Auditory Perceptual Disorders; Auditory area; Basal Ganglia; Behavior; Cells; Child; Code; Cognition; Cognitive; Complex; Comprehension; Corpus striatum structure; Data; Decision Making; Development; Diagnosis; Diagnostic; Disease; Dorsal; Electrophysiology (science); Evaluation; Foundations; Frequencies; Genetic; Goals; Hearing; Human; Impairment; Injury; Investigation; Knowledge; Link; Methods; Movement; Mus; Nervous system structure; Neurons; Outcome; Output; Pathway interactions; Pattern; Population; Process; Research; Role; Sensory; Signal Transduction; Site; Stimulus; Study models; Testing; Thalamic structure; Therapeutic; Trauma; Work; auditory pathway; auditory thalamus; awake; base; behavior influence; behavioral response; cognitive process; flexibility; improved; innovation; insight; nerve supply; neuromechanism; novel; optogenetics; relating to nervous system; response; sensory stimulus; sound; sound frequency; tool

Project Summary/Abstract The long-term goal of this research is to identify the neural mechanisms by which attention and changes in context influence the interpretation of sounds. In its simplest form, sound interpretation requires linking acoustic signals to behavioral responses. The objective of this proposal is to de- termine the contribution of distinct auditory pathways to sound-driven choices. This research will employ the mouse as a model organism and use genetic tools to identify specific cell populations according to their projection patterns. The first aim will test whether auditory thalamic and cortical circuits provide distinct acoustic information to basal ganglia regions involved in action selection. The second aim will identify the acoustic features represented by neurons from distinct basal gan- glia pathways. The third aim will test whether these neurons represent the meaning of a stimulus in addition to its acoustic features. The proposal is innovative not only in its use of genetic tools for the characterization of auditory pathways, but also in its evaluation of the role of auditory thalamic outputs to the basal ganglia. Moreover, these studies will help establish the mouse as an effective model for the study of auditory cognition, opening new avenues for detailed investigation of the neural basis of sound-driven behaviors. The proposed research is significant because it addresses es- sential steps towards identifying neural sites where context and sensory information are integrated to achieve flexible decision-making. This knowledge will greatly advance understanding of the neu- ral mechanisms underlying sound interpretation, and provide insights into how auditory cognition is affected by disease.

项目概要/摘要 这项研究的长期目标是确定注意力和注意力的神经机制 上下文的变化会影响对声音的解释。以最简单的形式，声音诠释 需要将声音信号与行为反应联系起来。该提案的目的是 终止不同听觉通路对声音驱动选择的贡献。这项研究将 使用小鼠作为模型生物并使用遗传工具来识别特定的细胞群 根据他们的投影模式。第一个目标将测试听觉丘脑和皮质是否 电路向参与动作选择的基底神经节区域提供独特的声学信息。 第二个目标是识别来自不同基底神经元的声学特征 神经胶质细胞通路。第三个目标将测试这些神经元是否代表刺激的含义 除了其声学特性之外。该提案的创新之处不仅在于它使用遗传工具 听觉通路的表征，还包括对听觉丘脑作用的评估 输出至基底神经节。此外，这些研究将有助于将小鼠确立为有效的 听觉认知研究模型，为详细研究听觉认知开辟了新途径 声音驱动行为的神经基础。拟议的研究意义重大，因为它解决了以下问题： 识别整合情境和感觉信息的神经位点的基本步骤 从而达到灵活决策的目的。这些知识将极大地促进对新事物的理解 声音解释背后的真实机制，并提供关于听觉认知如何进行的见解 受到疾病的影响。