Contribution of distinct auditory pathways to sound-driven choices.

不同的听觉通路对声音驱动的选择的贡献。

• 批准号: 9305048
• 负责人: Santiago Jaramillo
• 金额: $ 30.75万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9305048
• 关键词: Acoustics; Address; Affect; Anatomy; Animal Model; Attention; Auditory; Auditory Evoked Potentials; Auditory Perceptual Disorders; Auditory area; Basal Ganglia; Behavior; Cells; Child; Code; Cognition; Cognitive; Complex; Comprehension; Corpus striatum structure; Data; Decision Making; Development; Diagnosis; Diagnostic; Disease; Dorsal; Electrophysiology (science); Evaluation; Foundations; Frequencies; Genetic; Goals; Hearing; Human; Impairment; Injury; Investigation; Knowledge; Link; Methods; Movement; Mus; Nervous system structure; Neurons; Outcome; Output; Pathway interactions; Pattern; Population; Process; Research; Role; Sensory; Signal Transduction; Site; Stimulus; Study models; Testing; Thalamic structure; Therapeutic; Trauma; Work; auditory pathway; auditory thalamus; awake; base; behavior influence; behavioral response; cognitive process; flexibility; improved; innovation; insight; nerve supply; neuromechanism; novel; optogenetics; relating to nervous system; response; sensory stimulus; sound; sound frequency; tool

Project Summary/Abstract The long-term goal of this research is to identify the neural mechanisms by which attention and changes in context influence the interpretation of sounds. In its simplest form, sound interpretation requires linking acoustic signals to behavioral responses. The objective of this proposal is to de- termine the contribution of distinct auditory pathways to sound-driven choices. This research will employ the mouse as a model organism and use genetic tools to identify specific cell populations according to their projection patterns. The first aim will test whether auditory thalamic and cortical circuits provide distinct acoustic information to basal ganglia regions involved in action selection. The second aim will identify the acoustic features represented by neurons from distinct basal gan- glia pathways. The third aim will test whether these neurons represent the meaning of a stimulus in addition to its acoustic features. The proposal is innovative not only in its use of genetic tools for the characterization of auditory pathways, but also in its evaluation of the role of auditory thalamic outputs to the basal ganglia. Moreover, these studies will help establish the mouse as an effective model for the study of auditory cognition, opening new avenues for detailed investigation of the neural basis of sound-driven behaviors. The proposed research is significant because it addresses es- sential steps towards identifying neural sites where context and sensory information are integrated to achieve flexible decision-making. This knowledge will greatly advance understanding of the neu- ral mechanisms underlying sound interpretation, and provide insights into how auditory cognition is affected by disease.

项目总结/摘要 这项研究的长期目标是确定神经机制， 语境的变化影响了对声音的理解。在最简单的形式中， 需要将声音信号与行为反应联系起来。这项建议的目的是- 确定不同的听觉通路对声音驱动选择的贡献。这项研究将 使用小鼠作为模式生物，并使用遗传工具来识别特定的细胞群 根据他们的投影模式。第一个目标是测试听觉丘脑和皮层 回路向参与动作选择的基底神经节区域提供不同的声学信息。 第二个目标将确定不同基底节神经元所代表的声学特征， 神经胶质通路第三个目标将测试这些神经元是否代表刺激的意义 除了它的声学特征之外。该提案不仅在利用遗传工具 听觉通路的表征，而且在其评价听觉丘脑的作用 输出到基底神经节。此外，这些研究将有助于建立小鼠作为一种有效的 模型的研究听觉认知，开辟了新的途径，详细调查 声音驱动行为的神经基础拟议的研究很重要，因为它解决了- 识别整合环境和感觉信息的神经部位的基本步骤 以实现灵活的决策。这一认识将大大促进对新的认识。 声音解释背后的听觉机制，并提供关于听觉认知如何 都受到疾病的影响