Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Human Energy Balance Core

堪萨斯代谢与肥胖研究中心 (KC-MORE) - 人体能量平衡核心

• 批准号: 10598019
• 负责人: Joseph E. Donnelly
• 金额: $ 29.71万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598019
• 关键词: Accelerometer; Adult; Air; Alzheimer' s Disease; Basal metabolic rate; Behavioral; Biological Markers; Body Composition; Body Weight; Body Weight decreased; Brain; Calibration; Centers of Research Excellence; Central Nervous System; Child; Clinical; Complex; Cost Analysis; Diet; Dose; Dual-Energy X-Ray Absorptiometry; Energy Intake; Energy Metabolism; Equipment; Exercise; Exercise Physiology; Food; Gastrointestinal tract structure; Goals; Home; Human; Indirect Calorimetry; Individual; Intake; Intellectual functioning disability; International; Intervention; Investigation; Kansas; Laboratories; Liver; Location; Macronutrients Nutrition; Magnetic Resonance Imaging; Measurement; Medical center; Metabolic; Metabolism; Micronutrients; Monitor; Obesity; Occupations; Overweight; Pancreas; Participant; Patient Self-Report; Peripheral; Physical activity; Plethysmography; Population; Prevention; Process; Recommendation; Registries; Research; Research Personnel; Research Project Grants; Research Support; Schools; Services; Special Population; Surveys; Techniques; Time; Training; Underserved Population; United States National Institutes of Health; Universities; Weight maintenance regimen; community setting; comorbidity; data registry; digital imaging; energy balance; evidence base; feeding; gut microbiome; human subject; intervention delivery; invention; metabolic abnormality assessment; novel strategies; nutrient absorption; nutrition; obesity treatment; physically handicapped; portability; programs; rural dwellers; secondary analysis; sedentary; stable isotope; training opportunity; wasting; weight maintenance

HUMAN ENERGY BALANCE CORE: PROJECT SUMMARY The Kansas Center for Metabolism and Obesity REsearch (KC-MORE) Human Energy Balance (HEB) core integrates facilities, equipment, and expertise currently on the University of Kansas Medical Center (KUMC) campus to support research and training on the prevention and treatment of overweight and obesity and to evaluate the impact of weight loss on obesity-related co-morbidities in a variety of populations including adults, children, and in special and underserved populations including individuals with intellectual and developmental disabilities, physical disabilities, Alzheimer's disease, and in rural residents. The HEB core will include 3 divisions. The Energy Expenditure and Exercise Physiology Division will support assessments of energy expenditure (laboratory-based and portable indirect calorimetry, stable isotopes, whole-room indirect calorimetry), body weight (calibrated scales), and body composition (dual energy x-ray absorptiometry, air displacement plethysmography). This Division will also provide the capability to deliver and document laboratory- based exercise dosed at specific levels of intensity and energy expenditure and to deliver and monitor both weight management and exercise inventions remotely to groups of participants in their homes. The Energy Intake Division will provide assessments of energy, macronutrient and micronutrient intake (direct observation, weighted and digital image plate waste, self-reports), assessments of biomarkers that are indicators of compliance to diet recommendations or nutrient absorption, and analysis of the gut microbiome which may play a role in energy balance. This Division also has the capacity to prepare and serve meals of specific energy and macronutrient intake for controlled feeding trials. The Clinical Weight Management Division will utilize the facilities and staff of our on-going KUMC clinical weight management program to provide training, a venue for pilot research projects, and a mechanism for the delivery of evidence-based weight management interventions developed by KC-MORE COBRE supported and other investigators. In addition to opportunities for training in clinical weight management, our clinical weight management program provides a venue to conduct pilot weight management trials and maintains a registry of data and contact information on over 3,000 previous and current participants for secondary analysis and pilot surveys. The establishment of the HEB core will centralize, for the first time on the KUMC campus, the facilities, equipment, expertise, and training opportunities to provide access to multiple techniques for the assessment of energy intake and energy expenditure suitable for use in weight management trials conducted in both laboratory and community settings. In addition, HEB core will provide training in the conduct of weight management trials in both laboratory and community settings using a variety of strategies for intervention delivery, reducing energy intake and increasing physical activity in adults, children, and in special and underserved populations.

人体能量平衡核心：项目摘要 堪萨斯代谢和肥胖研究中心（KC-MORE）人体能量平衡（HEB）核心 整合了堪萨斯大学医学中心（KUMC）现有的设施、设备和专业知识 校园，以支持研究和培训的预防和治疗超重和肥胖， 评估体重减轻对包括成人在内的各种人群中肥胖相关合并症的影响， 儿童，以及特殊和服务不足的人群，包括智力和发育障碍的个人 残疾、肢体残疾、老年痴呆症和农村居民。HEB核心将包括3个 分裂能量消耗和运动生理学司将支持对能量消耗和运动生理学的评估。 支出（实验室和便携式间接量热法、稳定同位素、全室间接量热法） 量热法）、体重（校准标度）和身体成分（双能X射线吸收法、空气 位移体积描记法）。该司还将提供提供和记录实验室- 基于运动剂量在特定水平的强度和能量消耗，并提供和监测两者 体重管理和锻炼发明远程地提供给在他们家中的参与者群体。能量摄入 该司将提供能量、常量营养素和微量营养素摄入量的评估（直接观察， 加权和数字图像板废物，自我报告），生物标志物的评估， 遵守饮食建议或营养吸收，以及分析肠道微生物组， 在能量平衡中的作用。该司也有能力准备和提供特定能量的膳食， 控制喂养试验的常量营养素摄入量。临床体重管理部门将利用 我们正在进行的KUMC临床体重管理计划的设施和工作人员提供培训， 试点研究项目，以及提供基于证据的体重管理干预措施的机制 由KC-MORE COBRE支持和其他研究人员开发。除了培训机会外， 临床体重管理，我们的临床体重管理计划提供了一个场地进行试点体重 管理试验，并保持了3,000多个以前和现在的数据和联系信息登记册 参与者进行二次分析和试点调查。HEB核心的建立将集中，因为 第一次在KUMC校园，设施，设备，专业知识和培训机会，提供访问 用于评估能量摄入和能量消耗的多种技术 在实验室和社区环境中进行的管理试验。此外，HEB核心将提供 在实验室和社区环境中进行体重管理试验的培训，使用各种 提供干预措施的战略，减少成人、儿童 以及特殊和服务不足的人群。