Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Human Energy Balance Core

人体能量平衡核心：项目总结 堪萨斯新陈代谢和肥胖研究中心(KC-MORE)人体能量平衡(HEB)核心 整合堪萨斯大学医学中心(KUMC)目前的设施、设备和专业知识 校园支持预防和治疗超重和肥胖的研究和培训，并 评估减肥对包括成年人在内的各种人群中肥胖相关共病的影响， 儿童，以及特殊和未得到充分服务的人群，包括智力和发育障碍的个人 残疾、肢体残疾、阿尔茨海默病和农村居民。HEB核心将包括3个 组织。能源支出和运动生理学司将支持对能源的评估 支出(基于实验室的便携式间接量热法、稳定同位素、全室间接 量热法)、体重(校准秤)和身体成分(双能x射线吸收法，空气 位移体积描记术)。该司还将提供交付和记录实验室的能力- 基于特定强度和能量消耗水平的运动剂量，并提供和监控两者 将体重管理和锻炼发明远程提供给家中的参与者群体。能量摄入 该司将提供对能量、大量营养素和微量营养素摄入量的评估(直接观察， 加权和数字图像板废物，自我报告)，作为以下指标的生物标志物的评估 遵守饮食建议或营养吸收，并分析肠道微生物群可能发挥的作用 在能量平衡中扮演一个角色。该司还有能力准备和供应特定能量的食物和 控制性喂养试验中的大量营养素摄入量。临床体重管理科将利用 我们正在进行的KUMC临床体重管理计划的设施和工作人员提供培训，场地 试点研究项目，以及提供循证体重管理干预措施的机制 由KC-More Cobre Support和其他调查人员开发。除了培训机会外， 临床体重管理，我们的临床体重管理计划提供了一个进行试点体重的场所 管理部门对3,000多个以前和现在的数据和联系信息进行试验和维护 二次分析和试点调查的参与者。HEB核心的建立将集中，对于 第一次来到KUMC校区，为他们提供设施、设备、专业知识和培训机会 适用于评估适用于体重的能量摄入和能量消耗的多种技术 在实验室和社区环境中进行的管理试验。此外，HEB CORE将提供 在实验室和社区环境中进行体重管理试验方面的培训，使用各种 提供干预的策略，减少成人、儿童的能量摄入和增加体力活动， 以及在特殊和服务不足的人群中。

HUMAN ENERGY BALANCE CORE: PROJECT SUMMARY The Kansas Center for Metabolism and Obesity REsearch (KC-MORE) Human Energy Balance (HEB) core integrates facilities, equipment, and expertise currently on the University of Kansas Medical Center (KUMC) campus to support research and training on the prevention and treatment of overweight and obesity and to evaluate the impact of weight loss on obesity-related co-morbidities in a variety of populations including adults, children, and in special and underserved populations including individuals with intellectual and developmental disabilities, physical disabilities, Alzheimer's disease, and in rural residents. The HEB core will include 3 divisions. The Energy Expenditure and Exercise Physiology Division will support assessments of energy expenditure (laboratory-based and portable indirect calorimetry, stable isotopes, whole-room indirect calorimetry), body weight (calibrated scales), and body composition (dual energy x-ray absorptiometry, air displacement plethysmography). This Division will also provide the capability to deliver and document laboratory- based exercise dosed at specific levels of intensity and energy expenditure and to deliver and monitor both weight management and exercise inventions remotely to groups of participants in their homes. The Energy Intake Division will provide assessments of energy, macronutrient and micronutrient intake (direct observation, weighted and digital image plate waste, self-reports), assessments of biomarkers that are indicators of compliance to diet recommendations or nutrient absorption, and analysis of the gut microbiome which may play a role in energy balance. This Division also has the capacity to prepare and serve meals of specific energy and macronutrient intake for controlled feeding trials. The Clinical Weight Management Division will utilize the facilities and staff of our on-going KUMC clinical weight management program to provide training, a venue for pilot research projects, and a mechanism for the delivery of evidence-based weight management interventions developed by KC-MORE COBRE supported and other investigators. In addition to opportunities for training in clinical weight management, our clinical weight management program provides a venue to conduct pilot weight management trials and maintains a registry of data and contact information on over 3,000 previous and current participants for secondary analysis and pilot surveys. The establishment of the HEB core will centralize, for the first time on the KUMC campus, the facilities, equipment, expertise, and training opportunities to provide access to multiple techniques for the assessment of energy intake and energy expenditure suitable for use in weight management trials conducted in both laboratory and community settings. In addition, HEB core will provide training in the conduct of weight management trials in both laboratory and community settings using a variety of strategies for intervention delivery, reducing energy intake and increasing physical activity in adults, children, and in special and underserved populations.