The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down Syndrome

促进体力活动预防患有唐氏综合症的成人患阿尔茨海默病

基本信息

  • 批准号:
    10583850
  • 负责人:
  • 金额:
    $ 15.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-08-01 至 2024-04-30
  • 项目状态:
    已结题

项目摘要

Project Summary The number of people with Down syndrome (DS) living the U.S. has grown from ~50,000 to ~250,700 over the past 70 yrs. Nearly all individuals with DS display pathology associated with Alzheimer's disease (AD) beginning as early as age 30. Previous research in typically developed adults suggests that increased moderate-to- vigorous physical activity (MVPA) may improve cognitive function and protect against age-related structural and functional changes in the brain; however, the potential impact of increased MVPA on the development of AD in adults with DS has not been evaluated. Despite the potential positive impact of MVPA on cognition and AD risk, participation in MVPA among young adults with DS is low. The limited research evaluating strategies for increasing MVPA in adults with DS and has been unsuccessful in increasing short- term (≤ 12 wks.) or long-term MVPA (12 mo.). Results from our preliminary investigation (12 wks.) which remotely delivers real-time MVPA, led by a trained health coach, to groups of adults with DS in their homes (n=27), via video conferencing on a tablet computer demonstrated high attendance, increased MVPA during group sessions, and improvements in cognitive function. However, the sustainability, impact on total daily MVPA, optimal session frequency, and potential impacts on cognitive function and brain health of remotely delivered group MVPA sessions in adults with DS are unknown. Therefore, we propose a 12 mo. early stage clinical trial in 80 non-demented adults with DS to determine the feasibility and potential efficacy of remotely delivered group MVPA sessions to increase daily MVPA, relative to a usual care control. Participants will be randomized to attend 40 min remotely delivered group MVPA sessions at a low frequency (1 session/wk.,RL), high frequency (3 sessions/wk., RH), or usual care control. Content for both the RL and RH arms will be identical with the exception of group session frequency (1 vs. 3/wk.). Consistent with the funding announcement PAR-18-877 this trial will assess the feasibility and potential effectiveness of the RL, RH, and UC interventions on MVPA, and gather initial estimates of the impact of MVPA on cognition and measure of brain health related to AD in adults with DS. This information is required to inform the development of adequately powered, late stage confirmatory trials to evaluate the role of increased MVPA to prevent or delay AD in adults with DS. Our primary aim will assess daily MVPA (min) in the RL, RH, and UC arms at baseline, 3, 6, 9, and 12 mos., and obtain effect sizes for change in MVPA over 12-mos. Secondary aim 1 will assess the impact of MVPA across the RL, RH, and UC arms on cardiovascular fitness, quality of life, cognitive function and brain parameters related to AD (whole and regional brain volume, functional connectivity, resting state MRI, cerebral blood flow) at baseline, 6, and 12 mos. Secondary aim 2 will determine the feasibility (retention, session attendance, use of recorded sessions (RH/RL only) and safety) of RL, RH, and UC arms.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Joseph E. Donnelly其他文献

Very low calorie diet with concurrent versus delayed and sequential exercise.
极低热量饮食并同时进行运动与延迟运动和序贯运动。
Family-style foodservice can meet US Dietary Guidelines for elementary school children.
家庭式餐饮服务符合美国小学生膳食指南。
  • DOI:
    10.1016/s0002-8223(00)00032-8
  • 发表时间:
    2000
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Joseph E. Donnelly;D. Jacobsen;P. Legowski;Susan L. Johnson;Pat McCOY
  • 通讯作者:
    Pat McCOY
Bmc Medical Research Methodology Open Access Reporting Quality of Randomized Trials in the Diet and Exercise Literature for Weight Loss
BMC 医学研究方法论开放获取报告饮食和运动减肥文献中随机试验的质量
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Cheryl A Gibson;Erik P. Kirk;J. LeCheminant;Bruce W Bailey Jr;Guoyuan Huang;Joseph E. Donnelly;Email;James D;Bruce;Guoyuan
  • 通讯作者:
    Guoyuan
Does increased prescribed exercise alter non‐exercise physical activity/energy expenditure in healthy adults? A systematic review
增加规定的运动量是否会改变健康成年人的非运动身体活动/能量消耗?
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    R. A. Washburn;Kate Lambourne;Amanda N. Szabo;Stephen D Herrmann;J. Honas;Joseph E. Donnelly
  • 通讯作者:
    Joseph E. Donnelly
Reducing the incidence of obesity in adults with developmental disabilities in Kansas
  • DOI:
    10.1016/j.dhjo.2008.10.051
  • 发表时间:
    2009-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Richard R. Saunders;Muriel D. Saunders;Joseph E. Donnelly;Bryan K. Smith;Debra K. Sullivan;Brian P. Erickson
  • 通讯作者:
    Brian P. Erickson

Joseph E. Donnelly的其他文献

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{{ truncateString('Joseph E. Donnelly', 18)}}的其他基金

Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Human Energy Balance Core
堪萨斯代谢与肥胖研究中心 (KC-MORE) - 人体能量平衡核心
  • 批准号:
    10598019
  • 财政年份:
    2022
  • 资助金额:
    $ 15.19万
  • 项目类别:
Weight management for adults with mobility related disabilities
患有行动障碍的成年人的体重管理
  • 批准号:
    10372132
  • 财政年份:
    2019
  • 资助金额:
    $ 15.19万
  • 项目类别:
The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down Syndrome
促进体力活动预防患有唐氏综合症的成人患阿尔茨海默病
  • 批准号:
    10840170
  • 财政年份:
    2019
  • 资助金额:
    $ 15.19万
  • 项目类别:
A Dyadic Approach for a Remote Physical Activity Intervention in Adults with Alzheimer's Disease and their Caregivers
对患有阿尔茨海默病的成人及其护理人员进行远程身体活动干预的二元方法
  • 批准号:
    10011754
  • 财政年份:
    2019
  • 资助金额:
    $ 15.19万
  • 项目类别:
The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down Syndrome
促进体力活动预防患有唐氏综合症的成人患阿尔茨海默病
  • 批准号:
    10381537
  • 财政年份:
    2019
  • 资助金额:
    $ 15.19万
  • 项目类别:
The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down Syndrome
促进体力活动预防患有唐氏综合症的成人患阿尔茨海默病
  • 批准号:
    9803052
  • 财政年份:
    2019
  • 资助金额:
    $ 15.19万
  • 项目类别:
A Dyadic Approach for a Remote Physical Activity Intervention in Adults with Alzheimer's Disease and their Caregivers
对患有阿尔茨海默病的成人及其护理人员进行远程身体活动干预的二元方法
  • 批准号:
    10663826
  • 财政年份:
    2019
  • 资助金额:
    $ 15.19万
  • 项目类别:
A Dyadic Approach for a Remote Physical Activity Intervention in Adults with Alzheimer's Disease and their Caregivers
对患有阿尔茨海默病的成人及其护理人员进行远程身体活动干预的二元方法
  • 批准号:
    10426283
  • 财政年份:
    2019
  • 资助金额:
    $ 15.19万
  • 项目类别:
A Dyadic Approach for a Remote Physical Activity Intervention in Adults with Alzheimer's Disease and their Caregivers
对患有阿尔茨海默病的成人及其护理人员进行远程身体活动干预的二元方法
  • 批准号:
    10198748
  • 财政年份:
    2019
  • 资助金额:
    $ 15.19万
  • 项目类别:
The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down Syndrome
促进体力活动预防患有唐氏综合症的成人患阿尔茨海默病
  • 批准号:
    10614451
  • 财政年份:
    2019
  • 资助金额:
    $ 15.19万
  • 项目类别:

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