Vanderbilt Hypertension and Blood Pressure Regulation Program

范德比尔特高血压和血压调节计划

• 批准号: 10597621
• 负责人: David G Harrison
• 金额: $ 38.26万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597621
• 关键词: Hypertension; blood pressure regulation; programs

ABSTRACT This is a new program to train the next generation of scientists in the fields of hypertension and blood pressure regulation. These conditions represent enormous health care problems. The new American Heart Association and American College of Cardiology Guidelines now classify almost 50% of the adult population as being hypertensive. Autonomic dysfunction, manifested by syncope, presyncope and postural intolerance, becomes increasingly common with age and is terribly disabling. Despite the commonality of these disorders, their precise etiology remains poorly defined. Moreover, they often associated with and share underlying mechanisms with other cardiovascular and metabolic disorders. It is therefore mandatory that we train and develop outstanding scientists to pursue these related areas of investigation. We propose to ultimately include 4 post-doctoral fellows and 2 predoctoral graduate students in Vanderbilt Hypertension and Blood Pressure Regulation (VHBPR) program. These trainees will be involved in three related facets of research. One has to do with understanding mechanisms of hypertension and end organ damage and the role inflammation and immune activation. Members of the VHBPR have led the field in defining mechanisms of immune activation in hypertension and related fields and this has evolved into a new understanding of the vascular, renal and cerebral dysfunction and damage that occurs in this and associated cardiovascular illnesses. Trainees involved in these programs will become familiar with an emerging area of immunology as it pertains to hypertension and cardiovascular diseases. The second important area of investigation is conducted by our Vanderbilt Autonomic Dysfunction Center. This center performs translational research involving laboratory, animal and clinical research. A third major area of investigation relates to bioinformatics of hypertension and drug responses. These studies are greatly facilitated by the BioVu database (the Vanderbilt DNA database) that contains DNA for >300,000 patients and the Synthetic derivative (de-identified medical records linked to BioVu) and are facilitated by our Division of Genetic Medicine and Center for Personalized Medicine. Our trainees will have the opportunity to initiate studies on medication-resistant hypertension, as more than 15,000 BioVU subjects with documented medication-resistant hypertension will have genome interrogation completed by 2018, including a large number of African American subjects. In addition to these laboratory research experiences, the VHBPR program includes seminars, didactic lectures and specialized course work devoted to career development, leadership, responsible conduct of research and work life balance. In addition to this core curriculum, trainees in specialized areas will participate in tailored coursework and workshops related to their specific areas of investigation. The ultimate goal is to train successful scientists that will successfully compete for future funding and who can pursue successful academic careers.

摘要 这是一项新的计划，旨在培养高血压和血液领域的下一代科学家 压力调节这些情况代表了巨大的卫生保健问题。新美国心脏 协会和美国心脏病学会指南现在将近50%的成年人 人群高血压。自主神经功能障碍，表现为晕厥、晕厥前期和 姿势不耐受，随着年龄的增长变得越来越普遍，并且非常残疾。尽管 这些疾病的共性，其确切的病因仍然不明确。此外，他们往往 与其他心血管和代谢疾病相关并共享潜在机制。是 因此，我们必须培养和发展杰出的科学家，以追求这些相关领域， 调查我们建议最终包括4名博士后研究员和2名博士前研究生 在范德比尔特高血压和血压调节（VHBPR）计划。这些学员将在 涉及三个相关的研究领域。一个是要了解高血压的机制 和终末器官损伤以及炎症和免疫激活的作用。VHBPR的成员领导了 在高血压和相关领域中定义免疫激活机制的领域， 发展成为对血管、肾脏和大脑功能障碍和损伤的新认识， 以及相关的心血管疾病。参与这些计划的学员将熟悉 随着免疫学领域的兴起，其涉及高血压和心血管疾病。的 第二个重要的研究领域是由我们的范德比尔特自主神经功能障碍中心进行的。这 中心进行转化研究，涉及实验室，动物和临床研究。第三大领域 的研究涉及高血压和药物反应的生物信息学。这些研究大大 由BioVu数据库（范德比尔特DNA数据库）提供便利，该数据库包含> 30万名患者的DNA 和合成衍生物（与BioVu相关的去识别医疗记录），并由我们的 遗传医学部和个性化医学中心。我们的学员将有机会 启动对耐药性高血压的研究，因为超过15，000名BioVU受试者 到2018年，记录在案的耐药高血压将完成基因组审讯， 包括大量的非裔美国人。除了这些实验室研究之外， VHBPR计划包括研讨会，教学讲座和专业课程工作 致力于职业发展，领导，负责任的研究和工作生活的平衡。在 除了这一核心课程外，专业领域的受训人员还将参加量身定制的课程， 与他们的具体调查领域有关的讲习班。最终目标是培养成功的科学家 他们将成功地竞争未来的资金，并能够追求成功的学术生涯。