Vanderbilt Hypertension and Blood Pressure Regulation Program

范德比尔特高血压和血压调节计划

• 批准号: 10385839
• 负责人: David G Harrison
• 金额: $ 41.45万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10385839
• 关键词: Hypertension; blood pressure regulation; programs

ABSTRACT This is a new program to train the next generation of scientists in the fields of hypertension and blood pressure regulation. These conditions represent enormous health care problems. The new American Heart Association and American College of Cardiology Guidelines now classify almost 50% of the adult population as being hypertensive. Autonomic dysfunction, manifested by syncope, presyncope and postural intolerance, becomes increasingly common with age and is terribly disabling. Despite the commonality of these disorders, their precise etiology remains poorly defined. Moreover, they often associated with and share underlying mechanisms with other cardiovascular and metabolic disorders. It is therefore mandatory that we train and develop outstanding scientists to pursue these related areas of investigation. We propose to ultimately include 4 post-doctoral fellows and 2 predoctoral graduate students in Vanderbilt Hypertension and Blood Pressure Regulation (VHBPR) program. These trainees will be involved in three related facets of research. One has to do with understanding mechanisms of hypertension and end organ damage and the role inflammation and immune activation. Members of the VHBPR have led the field in defining mechanisms of immune activation in hypertension and related fields and this has evolved into a new understanding of the vascular, renal and cerebral dysfunction and damage that occurs in this and associated cardiovascular illnesses. Trainees involved in these programs will become familiar with an emerging area of immunology as it pertains to hypertension and cardiovascular diseases. The second important area of investigation is conducted by our Vanderbilt Autonomic Dysfunction Center. This center performs translational research involving laboratory, animal and clinical research. A third major area of investigation relates to bioinformatics of hypertension and drug responses. These studies are greatly facilitated by the BioVu database (the Vanderbilt DNA database) that contains DNA for >300,000 patients and the Synthetic derivative (de-identified medical records linked to BioVu) and are facilitated by our Division of Genetic Medicine and Center for Personalized Medicine. Our trainees will have the opportunity to initiate studies on medication-resistant hypertension, as more than 15,000 BioVU subjects with documented medication-resistant hypertension will have genome interrogation completed by 2018, including a large number of African American subjects. In addition to these laboratory research experiences, the VHBPR program includes seminars, didactic lectures and specialized course work devoted to career development, leadership, responsible conduct of research and work life balance. In addition to this core curriculum, trainees in specialized areas will participate in tailored coursework and workshops related to their specific areas of investigation. The ultimate goal is to train successful scientists that will successfully compete for future funding and who can pursue successful academic careers.

抽象的 这是一个新的计划，旨在培训高血压和血液领域的下一代科学家 压力调节。这些情况代表了巨大的医疗保健问题。新的美国心脏 协会和美国心脏病学院指南现在将近50％的成人分类 人口是高血压。自主功能障碍，表现为晕厥，前同步和 姿势不宽容，随着年龄的增长而变得越来越普遍，并且非常残疾。尽管有 这些疾病的通用性，其精确的病因仍然很差。而且，他们经常 与其他心血管和代谢性疾病相关并共享基本机制。这是 因此，必须训练和发展杰出科学家，以追求这些相关领域 调查。我们建议最终包括4名博士后研究员和2名研究生 在范德比尔特高血压和血压调节（VHBPR）计划中。这些学员将是 参与研究的三个相关方面。与理解高血压机制有关 并结束器官损伤以及炎症和免疫激活的作用。 VHBPR的成员已领导 定义高血压和相关领域免疫激活机制的领域，这有 发展为对血管，肾脏和脑功能障碍的新理解以及发生的损害 在这种和相关的心血管疾病中。参与这些计划的学员将变得熟悉 与高血压和心血管疾病有关的免疫学领域。这 第二重要的调查领域由我们的范德比尔特自主神经功能障碍中心进行。这 中心进行涉及实验室，动物和临床研究的转化研究。第三个主要区域 研究与高血压和药物反应的生物信息学有关。这些研究非常 由BIOVU数据库（Vanderbilt DNA数据库）促进，该数据库包含> 300,000名患者的DNA 以及合成衍生物（与BIOVU相关的取消识别的医疗记录），并由我们的促进 遗传医学和个性化医学中心。我们的学员将有机会 开始对耐药性高血压进行研究，作为15,000多名BIOVU受试者 有记录的耐药性高血压将在2018年之前完成基因组询问， 包括大量非裔美国人。除了这些实验室研究 经验，VHBPR计划包括研讨会，教学演讲和专业课程工作 致力于职业发展，领导，负责任的研究和工作生活平衡。在 除此核心课程外，专业领域的学员将参加量身定制的课程和 讲习班与他们的特定调查领域有关。最终目标是培训成功的科学家 这将成功竞争未来的资金，谁能从事成功的学术职业。