The Effect of Visual Stimuli on Sound Representation in the Macaque Inferior Colliculus

视觉刺激对猕猴下丘声音表征的影响

• 批准号: 10601229
• 负责人: Meredith Nicole Schmehl
• 金额: $ 4.68万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10601229
• 关键词: Address; Area; Auditory; Behavior; Brain; Brain region; Central Auditory Processing Disorder; Code; Communication; Communities; Complex; Cues; Development; Electrophysiology (science); Environment; Event; Eye; Eye Movements; Fellowship; Foundations; Hearing; Inferior Colliculus; Knowledge; Lead; Left; Light; Link; Location; Macaca; Macaca mulatta; Modality; Modeling; Monkeys; Neurons; Pattern; Performance; Population; Positioning Attribute; Preparation; Presbycusis; Process; Research; Resources; Role; Science; Sensory; Shapes; Side; Signal Transduction; Sound Localization; Stimulus; Structure; Testing; Time; Training; Universities; Vision; Visual; Work; auditory stimulus; awake; career; experimental study; extracellular; insight; multisensory; neural correlate; preservation; relating to nervous system; response; skills; sound; superior colliculus Corpora quadrigemina; visual information; visual stimulus

PROJECT SUMMARY/ABSTRACT: Visual cues can help the brain localize sounds. At the neural level, the brain might accomplish this by altering its response to sounds in the presence of visual signals. This could occur for single sounds, allowing the brain to use visual information to guide sound localization. This could also occur for multiple sounds, allowing the brain to connect visual information to the appropriate sound in a noisy environment. To test these possibilities, two rhesus macaques will perform a task in which they will localize one or two sounds in the presence or absence of accompanying lights. While the monkeys perform this task, we will record from single and multiple neurons in the inferior colliculus (IC), a critical auditory region that receives visual input and has visual and eye movement-related responses. To test whether visual cues alter the representation of single sounds, monkeys will localize a sound, light, or sound-light pair at a shared location. We expect that IC neurons will have a different response to sounds than to sound-light pairs. To test whether visual cues alter the time-varying response to multiple sounds, monkeys will detect two simultaneous sounds, each of which dominates the response of the neuron during distinct periods of time. We will compare IC neurons’ responses to two sounds, two sounds with one paired to a light, and two sounds with both paired to a light. When one sound is paired to a light, we predict that IC activity will skew toward the visually-paired sound. These experiments will help clarify the influence of visual cues on auditory responses and will provide insight into how the brain combines visual and auditory information into a single perceptual object. In addition to the proposed research, a training plan will also be carried out at Duke University, an environment offering many resources for both academic and professional development. The fellowship training plan takes advantage of opportunities both at Duke and in the community to support preparation for a research career with an emphasis on science communication. The proposed research will also facilitate professional development through the advancement of technical, analytical, and communication skills.

项目摘要/摘要： 视觉提示可以帮助大脑定位声音。在神经层面上，大脑可能会通过改变 它在视觉信号存在时对声音的反应。这可能发生在单一的声音上，允许大脑 利用视觉信息指导声音定位。对于多个声音也可能发生这种情况，从而允许 大脑在嘈杂的环境中将视觉信息与适当的声音联系起来。 为了测试这些可能性，两只恒河猴将执行一项任务，在这项任务中，它们将定位一只或两只猕猴 有无伴光时发出的声音。当猴子执行这项任务时，我们将 下丘(IC)中单个和多个神经元的记录，下丘是接收 视觉输入，并有视觉和眼动相关的反应。测试视觉提示是否会改变 作为单一声音的代表，猴子将声音、光或声光对定位在一个共享的位置。 我们预计，IC神经元对声音的反应将不同于对声光对的反应。来测试一下 视觉提示改变了对多种声音的时变反应，猴子会检测到两种同时发出的声音， 它们中的每一个在不同的时间段主导神经元的反应。我们将比较IC 神经元对两种声音的反应，两种声音其中一种与光配对，两种声音都与一种声音配对 灯。当一个声音与光配对时，我们预测IC活动将向视觉配对的声音倾斜。 这些实验将有助于阐明视觉线索对听觉反应的影响，并将提供洞察力 研究大脑如何将视觉和听觉信息组合成一个单一的感知对象。 除了拟议的研究外，杜克大学还将实施一项培训计划 为学术和职业发展提供许多资源。团契培训计划需要 利用杜克大学和社区的机会，支持为研究事业做准备 重点放在科学交流上。拟议的研究还将促进专业人士 通过提高技术、分析和沟通技能来实现发展。