The Effect of Visual Stimuli on Sound Representation in the Macaque Inferior Colliculus

视觉刺激对猕猴下丘声音表征的影响

• 批准号: 10601229
• 负责人: Meredith Nicole Schmehl
• 金额: $ 4.68万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10601229
• 关键词: Address; Area; Auditory; Behavior; Brain; Brain region; Central Auditory Processing Disorder; Code; Communication; Communities; Complex; Cues; Development; Electrophysiology (science); Environment; Event; Eye; Eye Movements; Fellowship; Foundations; Hearing; Inferior Colliculus; Knowledge; Lead; Left; Light; Link; Location; Macaca; Macaca mulatta; Modality; Modeling; Monkeys; Neurons; Pattern; Performance; Population; Positioning Attribute; Preparation; Presbycusis; Process; Research; Resources; Role; Science; Sensory; Shapes; Side; Signal Transduction; Sound Localization; Stimulus; Structure; Testing; Time; Training; Universities; Vision; Visual; Work; auditory stimulus; awake; career; experimental study; extracellular; insight; multisensory; neural correlate; preservation; relating to nervous system; response; skills; sound; superior colliculus Corpora quadrigemina; visual information; visual stimulus

PROJECT SUMMARY/ABSTRACT: Visual cues can help the brain localize sounds. At the neural level, the brain might accomplish this by altering its response to sounds in the presence of visual signals. This could occur for single sounds, allowing the brain to use visual information to guide sound localization. This could also occur for multiple sounds, allowing the brain to connect visual information to the appropriate sound in a noisy environment. To test these possibilities, two rhesus macaques will perform a task in which they will localize one or two sounds in the presence or absence of accompanying lights. While the monkeys perform this task, we will record from single and multiple neurons in the inferior colliculus (IC), a critical auditory region that receives visual input and has visual and eye movement-related responses. To test whether visual cues alter the representation of single sounds, monkeys will localize a sound, light, or sound-light pair at a shared location. We expect that IC neurons will have a different response to sounds than to sound-light pairs. To test whether visual cues alter the time-varying response to multiple sounds, monkeys will detect two simultaneous sounds, each of which dominates the response of the neuron during distinct periods of time. We will compare IC neurons’ responses to two sounds, two sounds with one paired to a light, and two sounds with both paired to a light. When one sound is paired to a light, we predict that IC activity will skew toward the visually-paired sound. These experiments will help clarify the influence of visual cues on auditory responses and will provide insight into how the brain combines visual and auditory information into a single perceptual object. In addition to the proposed research, a training plan will also be carried out at Duke University, an environment offering many resources for both academic and professional development. The fellowship training plan takes advantage of opportunities both at Duke and in the community to support preparation for a research career with an emphasis on science communication. The proposed research will also facilitate professional development through the advancement of technical, analytical, and communication skills.

项目摘要/摘要： 视觉提示可以帮助大脑本地化的声音。在神经层面，大脑可能通过改变 它在存在视觉信号的情况下对声音的响应。这可能会给单一声音而发生，使大脑 使用视觉信息指导声音本地化。这也可能发生多种声音，允许 大脑将视觉信息连接到噪声环境中的适当声音。 为了测试这些可能性，两个恒河猕猴将执行一项任务，在其中将其本地化一个或两个 在存在或没有参与灯的情况下发出声音。当猴子执行此任务时，我们将 从下丘（IC）中的单个神经元和多个神经元记录，这是一个接收的关键听觉区域 视觉输入，并具有视觉和眼睛运动相关的响应。测试视觉提示是否改变了 猴子表示单声音，将在共享位置定位声音，光线或光线。 我们希望IC神经元对声音的反应与对声音对的反应不同。测试是否 视觉提示改变了对多种声音的时变响应，猴子将检测到两种简单的声音， 每一个都在不同的时期主导神经元的反应。我们将比较IC 神经元对两种声音的响应，两种声音，一张搭配到光，两种声音都配对 光。当一种声音与光配对时，我们预测IC活动将偏向视觉配对的声音。 这些实验将有助于确定视觉提示对听觉响应的影响，并提供洞察力 大脑如何将视觉和听觉信息结合到单个感知对象中。 除了拟议的研究外，还将在杜克大学（Duke University）进行培训计划 为学术和专业发展提供许多资源。奖学金培训计划需要 在杜克大学和社区中的机会的优势，以支持为研究职业做准备 强调科学交流。拟议的研究还将促进专业 通过发展技术，分析和沟通技巧来发展。