The Effect of Visual Stimuli on Sound Representation in the Macaque Inferior Colliculus

视觉刺激对猕猴下丘声音表征的影响

• 批准号: 10601229
• 负责人: Meredith Nicole Schmehl
• 金额: $ 4.68万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10601229
• 关键词: Address; Area; Auditory; Behavior; Brain; Brain region; Central Auditory Processing Disorder; Code; Communication; Communities; Complex; Cues; Development; Electrophysiology (science); Environment; Event; Eye; Eye Movements; Fellowship; Foundations; Hearing; Inferior Colliculus; Knowledge; Lead; Left; Light; Link; Location; Macaca; Macaca mulatta; Modality; Modeling; Monkeys; Neurons; Pattern; Performance; Population; Positioning Attribute; Preparation; Presbycusis; Process; Research; Resources; Role; Science; Sensory; Shapes; Side; Signal Transduction; Sound Localization; Stimulus; Structure; Testing; Time; Training; Universities; Vision; Visual; Work; auditory stimulus; awake; career; experimental study; extracellular; insight; multisensory; neural correlate; preservation; relating to nervous system; response; skills; sound; superior colliculus Corpora quadrigemina; visual information; visual stimulus

PROJECT SUMMARY/ABSTRACT: Visual cues can help the brain localize sounds. At the neural level, the brain might accomplish this by altering its response to sounds in the presence of visual signals. This could occur for single sounds, allowing the brain to use visual information to guide sound localization. This could also occur for multiple sounds, allowing the brain to connect visual information to the appropriate sound in a noisy environment. To test these possibilities, two rhesus macaques will perform a task in which they will localize one or two sounds in the presence or absence of accompanying lights. While the monkeys perform this task, we will record from single and multiple neurons in the inferior colliculus (IC), a critical auditory region that receives visual input and has visual and eye movement-related responses. To test whether visual cues alter the representation of single sounds, monkeys will localize a sound, light, or sound-light pair at a shared location. We expect that IC neurons will have a different response to sounds than to sound-light pairs. To test whether visual cues alter the time-varying response to multiple sounds, monkeys will detect two simultaneous sounds, each of which dominates the response of the neuron during distinct periods of time. We will compare IC neurons’ responses to two sounds, two sounds with one paired to a light, and two sounds with both paired to a light. When one sound is paired to a light, we predict that IC activity will skew toward the visually-paired sound. These experiments will help clarify the influence of visual cues on auditory responses and will provide insight into how the brain combines visual and auditory information into a single perceptual object. In addition to the proposed research, a training plan will also be carried out at Duke University, an environment offering many resources for both academic and professional development. The fellowship training plan takes advantage of opportunities both at Duke and in the community to support preparation for a research career with an emphasis on science communication. The proposed research will also facilitate professional development through the advancement of technical, analytical, and communication skills.

项目总结/摘要： 视觉线索可以帮助大脑定位声音。在神经层面，大脑可能通过改变 在视觉信号出现时对声音的反应。这可能发生在单一的声音上， 使用视觉信息来指导声音定位。这也可能发生在多个声音上， 在嘈杂的环境中，大脑将视觉信息与适当的声音联系起来。 为了测试这些可能性，两只恒河猴将执行一项任务， 在有或没有伴随灯光的情况下发出的声音。当猴子完成这项任务时，我们将 来自下丘（IC）中单个和多个神经元的记录，下丘是一个关键的听觉区域， 视觉输入，并具有视觉和眼球运动相关的反应。为了测试视觉提示是否会改变 代表单一声音，猴子会将声音、光或声-光对定位在一个共享位置。 我们预计IC神经元对声音的反应将不同于对声-光对的反应。来测试是否 视觉线索改变了对多种声音的时变反应，猴子会发现两种同时出现的声音， 每一个都在不同的时间段期间支配神经元的响应。我们将比较IC 神经元对两种声音的反应，两种声音中的一种与光配对，两种声音中的两种都与光配对。 光当一个声音与一盏灯配对时，我们预测IC活动将向视觉配对的声音倾斜。 这些实验将有助于阐明视觉线索对听觉反应的影响， 大脑如何将视觉和听觉信息结合成一个单一的感知对象。 除了拟议中的研究外，还将在杜克大学开展一项培训计划， 为学术和专业发展提供了许多资源。研究金培训计划需要 在杜克和社区的机会优势，以支持研究生涯的准备 强调科学传播。这项研究还将促进专业 通过技术，分析和沟通技能的进步来发展。