权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Plasticity of sweet taste: importance of diet and receptor expression in taste buds

甜味的可塑性：饮食和味蕾受体表达的重要性

基本信息

批准号：
10600839
负责人：
Alissa Allen Nolden
金额：
$ 15.47万
依托单位：
UNIVERSITY OF MASSACHUSETTS AMHERST
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10600839
关键词：
Adverse effects Age Altered Taste Animals Behavior Behavioral Beverages Biological Biological Factors Biology Biopsy Broccoli - dietary Caffeine Characteristics Complex Consumption Cross-Sectional Studies Data Detection Diabetes Mellitus Diet Diet Habits Diet Modification Dietary intake Enrollment Esthesia Exposure to Food Food Preferences Fungiform Papilla Gene Expression Genetic Goals Health Hormones Human Individual Individual Differences Intake Intervention Studies Investigation Knowledge Link Measures Mediating Modification Molecular Obese Mice Obesity Oral Participant Pathway interactions Patient Self-Report Perception Physiology Play Procedures Process Propylthiouracil Psychophysics Qualifying Receptor Gene Recording of previous events Reporting Research Role Saccharin Sensory Sodium Chloride Stimulus Study Subject Sucrose Sweetening Agents Taste Buds Taste Perception Thinness Time Tissue Harvesting Tissues Weight Weight Gain Work clinically significant density detection of nutrient dietary experience human subject improved interdisciplinary approach mouse model novel strategies nutrition preference receptor expression response sex sugar sweet taste perception taste system

项目摘要

PROJECT SUMMARY Consumers report taste as the number one driver of food choice. Yet, taste perception can vary greatly across individuals and is associated with dietary preferences and food choice, with potential to impact nutrition and health. Conversely, dietary habits are known to impact taste response. For example, diets high in sugary foods and beverages are associated with reduced sweet taste function. However, the pathway in which humans experience plasticity of the sweet taste perception has yet to be elucidated. A recent study in a mouse model suggests that dietary exposure to saccharin modulates gene expression of a sweet taste receptor. The overall research goal of the present proposal is to establish fundamental knowledge of sweet taste receptor biology in humans, in terms of dietary intake, taste perception, and individual characteristics. Our hypothesis is that greater exposure to sweet foods and beverages will be associated with lower sweet taste function and reduced expression of the sweet taste receptor gene. Thus, our Aims are to investigate the expression of the sweet taste receptor in human taste buds in regards to 1) intake of sweet foods and beverages, 2) modulation due to exposure to sweet stimulus, and 3) individual characteristics (e.g., taste genetics). We will achieve these aims by combining interdisciplinary approaches between biology and sensory psychophysics. Using a non-invasive biopsy procedure, we can collect taste buds from human lingual tissue by harvesting fungiform papillae. Using these tissues, we can quantify expression levels of taste receptor genes, allowing for qualifying the relationship with taste function and explore how exposure modulates expression levels over time. This proposal includes two human subject studies, a cross-sectional study looking between high and low consumers of sweet foods and beverages and a 5-week longitudinal exposure study. Both studies include measures of taste intensity and sensitivity, intake and preferences for sweet foods and beverages, fungiform papillae density, taste receptor genetics, and taste receptor expression. The proposed study will provide new information regarding the molecular and cellular mechanisms regulating sweet taste receptor expression and further establish a link between dietary intake, taste psychophysics, and food behavior. A greater understanding of the plasticity of sweet taste and its underlying mechanism may contribute to clinical significance in understanding of the health implications linked with consumption of sweet foods and beverages, such as obesity and diabetes. Long-term objectives include identifying strategies to improve taste perception through dietary modification. This would be impactful for individuals with reduced or altered taste function in order to improve dietary quality and nutrition.

项目总结