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Neural Computations Underlying Vocal Sensorimotor Transformations

声音感觉运动转换的神经计算

基本信息

批准号：
10600133
负责人：
MICHAEL A LONG
金额：
$ 65.69万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10600133
关键词：
Acoustics Address Anatomy Behavior Bilateral Biological Models Biology Brain Brain region Communication Communication impairment Complex Cues Electric Stimulation Electrodes Engineering Experimental Designs Human Individual Insecta Knowledge Label Laboratories Link Mediating Methods Mission Monitor Motor Motor Cortex Movement Mus Muscimol Muscle Neurobiology Pathway interactions Perception Persons Population Process Production Protocols documentation Publications Research Rodent Role Science Sensory Series Site Speech Stereotyping Stimulus Structure Synapses Testing United States National Institutes of Health Work analytical method behavioral response density design experience experimental study flexibility insight neural neural circuit neuromechanism nonhuman primate optogenetics orofacial response role model sensory stimulus social vocalization

项目摘要

Project Summary/Abstract This project aims to investigate the circuit mechanisms enabling an ethologically relevant sensorimotor transformation. Specifically, we characterize the neural basis for rapid vocal exchanges in the singing mouse (Scotinomys teguina), a highly vocal neotropical rodent species capable of producing an audible, stereotyped song. Pairs of S. teguina often precisely coordinate the timing of their vocalizations in a process known as countersinging. In preliminary work, we revealed a short-latency pathway from an orofacial region of motor cortex to the muscles involved in vocal production. In this proposal, we will test the hypothesis that neural dynamics in motor cortex, guided by selective acoustic cues, can modify downstream song production circuits to enable rapid vocal communication across individuals. From these studies, we will perform the first characterization of the circuit mechanisms underlying rapid vocal exchanges in a mammalian model system. In Aim 1, we will characterize the acoustic aspects of song that elicit countersinging behavior. We will examine responses to the playback of a range of natural and synthetic sensory stimuli to test perceptual boundaries and factors leading to vocal responsiveness. In Aim 2, we will use several complementary perturbations to address the role of motor cortex on vocal production and countersinging coordination. In Aim 3, we will use population recordings to examine the responses of cortical neural populations during vocal perception and production. We will then characterize the broader neural circuitry leading to countersinging by uncovering both upstream and downstream synaptic partners.

项目摘要/摘要本项目旨在研究一种与行为学相关的感觉运动的回路机制。转型。具体地说，我们描述了歌唱中快速发声的神经基础。老鼠(Scotinomys Teguina)，一种声音很大的新热带啮齿动物，能够发出声音，刻板印象的歌曲。在一个发声过程中，一对特吉纳人经常精确地协调它们发声的时间这就是所谓的对唱。在前期工作中，我们揭示了口腔面部区域的一条短潜伏期路径。运动皮质到参与发声的肌肉。在这个提案中，我们将检验假设在选择性声学提示的引导下，运动皮质的神经动力学可以改变下游的歌声生产电路，以实现跨个人的快速语音通信。从这些研究中，我们将对快速发声交换背后的电路机制进行首次表征哺乳动物模型系统。在目标1中，我们将描述歌曲引发反唱行为的声学特征。我们会检查对一系列自然和合成感觉刺激回放的反应，以测试知觉导致发声反应的界限和因素。在目标2中，我们将使用几个互补的扰动来解决运动皮质在发声中的作用制作和演唱的协调。在目标3中，我们将使用群体记录来检查皮质神经群体的反应在声音的感知和产生过程中。然后我们将描述更广泛的神经电路的特征通过发现上游和下游突触伙伴来对抗歌唱。