权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Neural Computations Underlying Vocal Sensorimotor Transformations

声音感觉运动转换的神经计算

基本信息

批准号：
10600133
负责人：
MICHAEL A LONG
金额：
$ 65.69万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10600133
关键词：
Acoustics Address Anatomy Behavior Bilateral Biological Models Biology Brain Brain region Communication Communication impairment Complex Cues Electric Stimulation Electrodes Engineering Experimental Designs Human Individual Insecta Knowledge Label Laboratories Link Mediating Methods Mission Monitor Motor Motor Cortex Movement Mus Muscimol Muscle Neurobiology Pathway interactions Perception Persons Population Process Production Protocols documentation Publications Research Rodent Role Science Sensory Series Site Speech Stereotyping Stimulus Structure Synapses Testing United States National Institutes of Health Work analytical method behavioral response density design experience experimental study flexibility insight neural neural circuit neuromechanism nonhuman primate optogenetics orofacial response role model sensory stimulus social vocalization

项目摘要

Project Summary/Abstract This project aims to investigate the circuit mechanisms enabling an ethologically relevant sensorimotor transformation. Specifically, we characterize the neural basis for rapid vocal exchanges in the singing mouse (Scotinomys teguina), a highly vocal neotropical rodent species capable of producing an audible, stereotyped song. Pairs of S. teguina often precisely coordinate the timing of their vocalizations in a process known as countersinging. In preliminary work, we revealed a short-latency pathway from an orofacial region of motor cortex to the muscles involved in vocal production. In this proposal, we will test the hypothesis that neural dynamics in motor cortex, guided by selective acoustic cues, can modify downstream song production circuits to enable rapid vocal communication across individuals. From these studies, we will perform the first characterization of the circuit mechanisms underlying rapid vocal exchanges in a mammalian model system. In Aim 1, we will characterize the acoustic aspects of song that elicit countersinging behavior. We will examine responses to the playback of a range of natural and synthetic sensory stimuli to test perceptual boundaries and factors leading to vocal responsiveness. In Aim 2, we will use several complementary perturbations to address the role of motor cortex on vocal production and countersinging coordination. In Aim 3, we will use population recordings to examine the responses of cortical neural populations during vocal perception and production. We will then characterize the broader neural circuitry leading to countersinging by uncovering both upstream and downstream synaptic partners.

项目总结/摘要本研究旨在探讨动物行为学相关的感觉运动的回路机制转型具体来说，我们描述了歌唱中快速发声交流的神经基础。小鼠（Scotinomys teguina），一种能发出声音的新热带啮齿动物，刻板的歌对S。teguina经常精确地协调它们发声的时间，被称为唱反调。在初步工作中，我们发现了一个短潜伏期的途径，从口面区域，运动皮层与发声肌肉的联系在本提案中，我们将检验以下假设：运动皮层的神经动力学，在选择性声音线索的引导下，可以修改下游的歌曲制作电路，实现个人之间的快速语音交流。通过这些研究，我们将执行电路机制的第一个表征，在一个快速的声音交换哺乳动物模型系统。在目标1中，我们将描述歌曲的声学方面，引起反唱行为。我们将检查对一系列自然和合成感官刺激的回放的反应，以测试感知导致声音反应的边界和因素。在目标2中，我们将使用几种互补的扰动来解决运动皮层对声乐的作用。制作和对位协调。在目标3中，我们将使用群体记录来检查皮质神经群体的反应在声音的感知和产生过程中。然后，我们将描述更广泛的神经回路，通过发现上游和下游突触伴侣来对抗歌唱。