Neural Computations Underlying Vocal Sensorimotor Transformations
声音感觉运动转换的神经计算
基本信息
- 批准号:10600133
- 负责人:
- 金额:$ 65.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-15 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AcousticsAddressAnatomyBehaviorBilateralBiological ModelsBiologyBrainBrain regionCommunicationCommunication impairmentComplexCuesElectric StimulationElectrodesEngineeringExperimental DesignsHumanIndividualInsectaKnowledgeLabelLaboratoriesLinkMediatingMethodsMissionMonitorMotorMotor CortexMovementMusMuscimolMuscleNeurobiologyPathway interactionsPerceptionPersonsPopulationProcessProductionProtocols documentationPublicationsResearchRodentRoleScienceSensorySeriesSiteSpeechStereotypingStimulusStructureSynapsesTestingUnited States National Institutes of HealthWorkanalytical methodbehavioral responsedensitydesignexperienceexperimental studyflexibilityinsightneuralneural circuitneuromechanismnonhuman primateoptogeneticsorofacialresponserole modelsensory stimulussocialvocalization
项目摘要
Project Summary/Abstract
This project aims to investigate the circuit mechanisms enabling an ethologically relevant sensorimotor
transformation. Specifically, we characterize the neural basis for rapid vocal exchanges in the singing
mouse (Scotinomys teguina), a highly vocal neotropical rodent species capable of producing an audible,
stereotyped song. Pairs of S. teguina often precisely coordinate the timing of their vocalizations in a process
known as countersinging. In preliminary work, we revealed a short-latency pathway from an orofacial region
of motor cortex to the muscles involved in vocal production. In this proposal, we will test the hypothesis that
neural dynamics in motor cortex, guided by selective acoustic cues, can modify downstream song
production circuits to enable rapid vocal communication across individuals. From these studies, we will
perform the first characterization of the circuit mechanisms underlying rapid vocal exchanges in a
mammalian model system.
In Aim 1, we will characterize the acoustic aspects of song that elicit countersinging behavior. We will
examine responses to the playback of a range of natural and synthetic sensory stimuli to test perceptual
boundaries and factors leading to vocal responsiveness.
In Aim 2, we will use several complementary perturbations to address the role of motor cortex on vocal
production and countersinging coordination.
In Aim 3, we will use population recordings to examine the responses of cortical neural populations
during vocal perception and production. We will then characterize the broader neural circuitry leading to
countersinging by uncovering both upstream and downstream synaptic partners.
项目总结/摘要
本研究旨在探讨动物行为学相关的感觉运动的回路机制
转型具体来说,我们描述了歌唱中快速发声交流的神经基础。
小鼠(Scotinomys teguina),一种能发出声音的新热带啮齿动物,
刻板的歌对S。teguina经常精确地协调它们发声的时间,
被称为唱反调。在初步工作中,我们发现了一个短潜伏期的途径,从口面区域,
运动皮层与发声肌肉的联系在本提案中,我们将检验以下假设:
运动皮层的神经动力学,在选择性声音线索的引导下,可以修改下游的歌曲
制作电路,实现个人之间的快速语音交流。通过这些研究,我们将
执行电路机制的第一个表征,在一个快速的声音交换
哺乳动物模型系统。
在目标1中,我们将描述歌曲的声学方面,引起反唱行为。我们将
检查对一系列自然和合成感官刺激的回放的反应,以测试感知
导致声音反应的边界和因素。
在目标2中,我们将使用几种互补的扰动来解决运动皮层对声乐的作用。
制作和对位协调。
在目标3中,我们将使用群体记录来检查皮质神经群体的反应
在声音的感知和产生过程中。然后,我们将描述更广泛的神经回路,
通过发现上游和下游突触伴侣来对抗歌唱。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A comparative characterization of laryngeal anatomy in the singing mouse.
- DOI:10.1111/joa.13315
- 发表时间:2021-03
- 期刊:
- 影响因子:2.4
- 作者:Smith SK;Burkhard TT;Phelps SM
- 通讯作者:Phelps SM
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{{ truncateString('MICHAEL A LONG', 18)}}的其他基金
Cortical Dynamics Underlying Interactive Language Use
交互语言使用的皮层动力学
- 批准号:
10184611 - 财政年份:2021
- 资助金额:
$ 65.69万 - 项目类别:
Cortical Dynamics Underlying Interactive Language Use
交互语言使用的皮层动力学
- 批准号:
10383706 - 财政年份:2021
- 资助金额:
$ 65.69万 - 项目类别:
Cortical Dynamics Underlying Interactive Language Use
交互语言使用的皮层动力学
- 批准号:
10613931 - 财政年份:2021
- 资助金额:
$ 65.69万 - 项目类别:
2020 Neural Mechanisms of Acoustic Communication Gordon Research Conference and Seminar
2020年声学交流的神经机制戈登研究会议暨研讨会
- 批准号:
9980608 - 财政年份:2020
- 资助金额:
$ 65.69万 - 项目类别:
Neural Computations Underlying Vocal Sensorimotor Transformations
声音感觉运动转换的神经计算
- 批准号:
10378771 - 财政年份:2019
- 资助金额:
$ 65.69万 - 项目类别:
Neural Computations Underlying Vocal Sensorimotor Transformations
声音感觉运动转换的神经计算
- 批准号:
9974583 - 财政年份:2019
- 资助金额:
$ 65.69万 - 项目类别:
Synaptic and circuit mechanisms of learned vocal production
学习性发声的突触和电路机制
- 批准号:
8668638 - 财政年份:2013
- 资助金额:
$ 65.69万 - 项目类别:
Synaptic and circuit mechanisms of learned motor sequences
学习运动序列的突触和电路机制
- 批准号:
10164869 - 财政年份:2011
- 资助金额:
$ 65.69万 - 项目类别:
Synaptic and circuit mechanisms of learned vocal production
学习性发声的突触和电路机制
- 批准号:
8534306 - 财政年份:2011
- 资助金额:
$ 65.69万 - 项目类别:
Synaptic and circuit mechanisms of learned vocal production
学习性发声的突触和电路机制
- 批准号:
8333299 - 财政年份:2011
- 资助金额:
$ 65.69万 - 项目类别:
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