Training in Translational Research in Pulmonary Vascular Biology

项目摘要/摘要 生物医学研究人员的集体能力正在受到限制，他们无法将 当代卓越的基础科学发现进入临床领域--一道鸿沟 被恰当地命名为“死亡之谷”。在我们的前两个融资周期中，我们建立了一个 在工作台到床边研究方法方面的强大的T32博士后培训计划旨在 培训下一代临床和基础研究人员采用翻译方法 肺血管生物学与医学。到目前为止，该项目已培训了23名学员， 在出版、拨款和获得学术职位方面取得重大成功的人； 这些受训人员中有13人是妇女，其中3人被确认为代表不足的少数群体。 我们的计划认识到科学创业和实践培训的必要性 生物技术，以及我们在加强这方面培训方面的努力，已产生了三名学员 获得工商管理硕士学位。在第三轮融资中，我们将继续发展和加强我们的 培训计划。我们专注于增加受训人员多样性的战略；以及 回应我们的学员对创业教育的要求，但没有承诺 获得MBA学位后，我们增加了微证书项目的选项，并形成了 创业教育委员会。进一步加强我们博士后的培养 并扩大我们计划的范围，我们将非正式地包括由当地居民参与 我们现有课程中精选部分内容的博士前学员。重要的是，我们的帖子- 博士生将继续由具有补充研究的教职员工共同指导。 提供全面培训的方法，以及以患者为中心的长凳项目- 床边研究，持续关注实习生职业发展。我们的教职员工包括 专注于翻译的内科-科学家和博士学位，涵盖基础科学到 创业家，在肺血管生物学方面有生产力的历史，出色的资金 从分子发现到临床试验的支持、成功的指导和专业知识 生物技术商业化。通过以下途径可获得大量的机构支持 对VMI的捐赠。拟议的培训计划、领导力、顾问委员会、培训 匹兹堡大学的教职员工和基础设施处于强有力的地位，可以在 已经丰富的板凳到床边翻译培训计划，并创建了一代 研究人员致力于跨越基础研究发现、 在肺血管疾病中的临床应用和商业可行性。

PROJECT SUMMARY/ABSTRACT Biomedical investigators are experiencing a limitation in their collective ability to translate the remarkable basic science discoveries of the current era into the clinical arena—a divide appropriately termed “the valley of death.” In our first two funding cycles, we have established a strong T32 postdoctoral training program in bench-to-bedside research methodology designed to train the next generation of clinical and basic researchers in translational approaches to pulmonary vascular biology and medicine. The program has thus far trained twenty-three trainees, who have had significant success in publication, grant funding, and securing academic positions; thirteen of these trainees were women, three identified as under-represented minorities (URM). Our program recognized the necessity for practical training in scientific entrepreneurship and biotechnology, and our efforts in bolstering this aspect of training have resulted in three trainees obtaining an MBA. In the third cycle of funding, we will continue to evolve and enhance our training program. We are focused on strategies to increase the diversity among our trainees; and in response to our trainees’ requests for entrepreneurship education without the commitment to obtaining an MBA, we have added options for micro-credential programs and formed an Entrepreneurship Educational Board. Further, to enhance the training of our post-doctoral trainees and expand the scope of our program, we will informally include participation by local pre-doctoral trainees in select components of our existing curriculum. Importantly, our post- doctoral trainees will continue to be co-mentored by a faculty with complementary research approaches to provide comprehensive training, and projects focused on patient-oriented bench- to-bedside research, with constant attention to trainee career development. Our faculty include translationally-focused physician-scientists and PhDs spanning basic science to entrepreneurship, with a history of productivity in pulmonary vascular biology, excellent funding support, successful mentoring, and expertise from molecular discovery to clinical trials to biotechnology commercialization. Substantial institutional support is available through endowments to the VMI. The proposed training program, leadership, advisory boards, training faculty, and infrastructure at the University of Pittsburgh are strongly positioned to build on an already rich bench-to-bedside translational training program and create a generation of researchers committed to spanning the “valley of death” between basic research discoveries, clinical application, and commercial viability in pulmonary vascular disease.