Core 2: Histopathology and Biospecimen Core

核心 2：组织病理学和生物样本核心

• 批准号: 10601296
• 负责人: ROBERT H PIERCE
• 金额: $ 5.1万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601296
• 关键词: Core; Histopathology; Biospecimen

Project Summary/Abstract – Histopathology and Biospecimen Core The Histopathology and Biospecimen Core (HBC) represents an integral component of the Fred Hutchinson Cancer Research Center (FHCRC) lung cancer SPORE, supporting the translational goals of the Projects as well as future SPORE-funded development projects. The mission of the HBC is to facilitate discovery and rapid translation of discoveries into clinical care. To this end, the HBC manages the acquisition, annotation, processing and distribution of biospecimens from patient-derived and SPORE-funded experimental mouse models. The HBC partners with NWBioTrust (NWBT), and Fred Hutchinson/University of Washington Cancer Consortium (CCSG) – a funded collaborative resource for obtaining high-quality, well-annotated and appropriately-consented and de-identified biospecimens for innovative research. In addition to biobanking activities, the HBC is responsible the for managing the performance of downstream tissue-based assays, leveraging a suite of cutting-edge histopathologic and imaging capabilities supported by the Fred Hutchinson Cancer Research Center (FHCRC) in its extensive network of Shared Resources. These capabilities include, but are not limited to, routine histopathologic services, pathology review and consultation, immunohistochemistry (IHC), branch-chain in-situ hybridization (ISH), DNA/RNA extraction, Nanostring-based transcriptional profiling, multiplex immunohistochemistry (mIHC) and digital image analysis. The HBC will provide SPORE investigators with biospecimens (e.g. serum), derivatives of biospecimens (e.g. unstained slides, DNA,RNA) as well as quality- controlled data (e.g. images and image analysis-based data).

项目概要/摘要-组织学和生物标本核心 组织学和生物标本核心（HBC）是弗雷德哈钦森 癌症研究中心（FHCRC）肺癌孢子，支持项目的转化目标， 以及未来的SPORE资助的发展项目。HBC的使命是促进发现和快速 将发现转化为临床护理。为此，HBC管理采集，注释， 来自患者来源和SPORE资助的实验小鼠的生物标本的处理和分发 模型HBC与NWBioTrust（NWBT）和Fred哈钦森/华盛顿癌症大学合作 联盟（CCSG）-一个资助的协作资源，用于获得高质量，注释良好， 适当同意和去识别的生物标本用于创新研究。除了生物库 活动，HBC负责管理下游基于组织的测定的性能， 利用弗雷德哈钦森支持的一套先进的组织病理学和成像能力， 癌症研究中心（FHCRC）在其广泛的共享资源网络。这些能力包括， 但不限于常规组织病理学服务、病理学审查和咨询、免疫组织化学 (IHC)、支链原位杂交（ISH）、DNA/RNA提取、基于Nanostring的转录谱分析、 多重免疫组织化学（mIHC）和数字图像分析。HBC将提供SPORE调查人员 生物标本（如血清）、生物标本衍生物（如未染色载玻片、DNA、RNA）以及质量- 受控数据（例如图像和基于图像分析的数据）。