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Defining and targeting mechanisms of pancreas cancer pathogenesis

胰腺癌发病机制的定义和靶向机制

基本信息

批准号：
10603096
负责人：
Martin Whittle
金额：
$ 6.14万
依托单位：
FRED HUTCHINSON CANCER CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-19 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10603096
关键词：
Defining targeting mechanisms pancreas cancer

项目摘要

Project Summary Dr. Martin Whittle is a senior scientist working in the laboratory of Dr. Sunil Hingorani at the Fred Hutchinson Cancer Research Center. Dr. Whittle’s training has provided him a strong foundation in the fields of molecular biology, cancer cell signaling, and tumor modeling in mice. This Research Specialist award will support Dr. Whittle’s effort on research projects central to the overall Hingorani Laboratory research program including the following three key projects: the complex pancreas cancer microenvironment and its contributions to disease pathogenesis and drug resistance; the immune reaction in PDA and development of effective immunotherapies; and the molecular underpinnings of the metastatic switch in pancreas cancer. Aside from performing vital experiments for each of these projects, Dr. Whittle further supports the Hingorani lab by training new technicians and postdoctoral fellows in fundamental and advanced laboratory techniques that are critical to the Hingorani research program, including genetic engineering, mouse model development and characterization, animal husbandry, surgical procedures and necropsies, primary tissue culture, histochemistry and immunohistology, genotyping PCR, qRT-PCR, western blotting, FACS, fluorescence microscopy, gene array, molecular cloning, ELISA, mass spectrometry and others.

项目摘要博士马丁·惠特尔是弗雷德哈钦森的苏尼尔·欣戈拉尼博士实验室的资深科学家癌症研究中心。惠特尔博士的训练为他在分子生物学领域打下了坚实的基础。生物学、癌细胞信号传导和小鼠肿瘤建模。该研究专家奖将支持博士。惠特尔在研究项目上的努力是整个欣戈拉尼实验室研究计划的核心，包括以下三个关键项目：复杂的胰腺癌微环境及其对疾病的贡献 PDA的发病机制和耐药性; PDA的免疫反应和有效治疗药物的开发免疫疗法;以及胰腺癌转移开关的分子基础。除了惠特尔博士为这些项目中的每一个进行了重要的实验，并通过以下方式进一步支持欣戈拉尼实验室：培训新的技术人员和博士后研究员的基础和先进的实验室技术， Hingorani研究计划的关键，包括基因工程，小鼠模型开发和表征、动物饲养、外科手术和尸检、原代组织培养、组织化学免疫组织学、基因分型PCR、qRT-PCR、蛋白质印迹、FACS、荧光显微镜、基因芯片、分子克隆、ELISA、质谱等。