Neural systems mediating the extinction and inhibition of cocaine seeking
Neural systems mediating the extinction and inhibition of cocaine seeking
批准号:
10610379
负责人:
RYAN T LALUMIERE
金额:
$44.29万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-07-15 至 2025-04-30
关键词:
Amygdaloid structureBehaviorBehavioralBrain regionCell NucleusCocaineCocaine DependenceConsumptionCustomDataDevelopmentDrug usageElementsEtiologyExtinctionFaceFailureFrequenciesFutureGoalsHeterogeneityHippocampusHumanImpairmentImplantIndividualKnowledgeLaboratoriesMedialMediatingModelingNeural PathwaysNeuronsNeurosciencesNucleus AccumbensOutputPathway AnalysisPathway interactionsPharmaceutical PreparationsPlayPrefrontal CortexProcessRattusRelapseResearchRodentRoleSiteStructureStructure of paraventricular nucleus of thalamusSystemTestingThalamic structureTrainingWorkcocaine relapsecocaine seekingcocaine self-administrationcocaine usecravingdesigneffective therapyexperimental studyinsightlearning extinctionmulti-electrode arraysneuralneural circuitnovel strategiesoptogeneticspublic health relevance
中文摘要
复吸可卡因仍然是治疗可卡因成瘾的一个重大挑战,然而我们的
英文摘要
Relapse to cocaine use remains a significant challenge in the treatment of cocaine addiction, yet our
understanding of those neural systems that enable individuals to inhibit cocaine seeking and relapse remains
poor. The long-term goal of our laboratory is to identify the neural circuits and the changes in those circuits that
underlie the inhibition of cocaine-seeking behavior, using rat models of cocaine seeking. The current proposal
builds upon the findings we have obtained in recent years as well as new approaches we have developed in
our laboratory. In our studies, rats undergo cocaine self-administration, extinction training and reinstatement
testing of their cocaine seeking. We have found that the infralimbic cortex is a central component of the
systems involved in the extinction and inhibition of cocaine-seeking behavior. Activity in the infralimbic cortex is
necessary for the normal encoding of the extinction learning as well as extinction expression. For example,
infralimbic activation inhibits cocaine seeking following extinction training. However, the larger circuit in which
the infralimbic cortex performs these functions remains unclear. In particular, as evidence suggests functional
heterogeneity within the infralimbic cortex in terms of its role in cocaine seeking, understanding the larger
circuitry may provide insight into these issues. The proposed work will focus on the specific pathways
projecting into and out of the infralimbic that account for its role in extinction and inhibition of cocaine seeking.
The work will include approaches that have not, to our knowledge, been used in studies of cocaine seeking
and, therefore, will enable notable progress in our knowledge of these systems. In particular, our studies will
use multi-site recordings of neural activity during cocaine seeking to understand how a network of brain
regions coordinates behavior. Moreover, the proposed studies will use optogenetic approaches to examine
how different pathways mediate different aspects of the extinction and inhibition of cocaine seeking. The
findings from this work will reveal those specific pathways and network activity related to the IL with regard to
the extinction/inhibition of cocaine seeking. Furthermore, the proposed work will both 1) examine changes in
IL-based circuits as a consequence of cocaine self-administration and extinction and 2) manipulate these
circuits to determine how they functionally control the inhibition of cocaine seeking. The findings from the
studies will furnish critical new basic knowledge of the neural systems underlying the suppression of cocaine
seeking that will potentially lead to the development of more effective treatments that strengthen such systems
in cocaine-addicted individuals.
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DOI:
10.1111/adb.13106
发表时间:
2022-01
期刊:
Addiction biology
影响因子:
3.4
作者:
[Müller Ewald VA, Kim J, Farley SJ, Freeman JH, LaLumiere RT]
通讯作者:
LaLumiere RT
Infralimbic Projections to the Nucleus Accumbens Shell and Amygdala Regulate the Encoding of Cocaine Extinction Learning.
下边缘对伏核壳和杏仁核的投射调节可卡因灭绝学习的编码。
DOI:
10.1523/jneurosci.2023-22.2022
发表时间:
2023
期刊:
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子:
--
作者:
[Nett,KelleE, Zimbelman,AlexaR, McGregor,MatthewS, AlizoVera,Vanessa, Harris,MollyR, LaLumiere,RyanT]
通讯作者:
LaLumiere,RyanT
Theoretical Considerations for Optimizing the Use of Optogenetics with Complex Behavior.
优化复杂行为光遗传学应用的理论考虑。
DOI:
10.1002/cpz1.836
发表时间:
2023
期刊:
Current protocols
影响因子:
--
作者:
[Glickman,Bess, LaLumiere,RyanT]
通讯作者:
LaLumiere,RyanT
DOI:
10.1016/j.neubiorev.2021.10.002
发表时间:
2021-12
期刊:
Neuroscience and biobehavioral reviews
影响因子:
8.2
作者:
[Nett KE, LaLumiere RT]
通讯作者:
LaLumiere RT
Neural circuits and mechanisms underlying active and passive stress coping
-
批准号:10681051
-
项目类别:
-
资助金额:$67.13万
-
财政年份:2023
-
负责人:RYAN T LALUMIERE
-
依托单位:
Circuit versus stress hormonal influences in consolidation of fear memory strength and precision.
-
批准号:10753860
-
项目类别:
-
资助金额:$48.7万
-
财政年份:2023
-
负责人:RYAN T LALUMIERE
-
依托单位:
Neural systems mediating the extinction and inhibition of cocaine seeking
-
批准号:10215464
-
项目类别:
-
资助金额:$44.29万
-
财政年份:2020
-
负责人:RYAN T LALUMIERE
-
依托单位:
Neural systems mediating the extinction and inhibition of cocaine seeking
-
批准号:10398959
-
项目类别:
-
资助金额:$44.29万
-
财政年份:2020
-
负责人:RYAN T LALUMIERE
-
依托单位:
Neural systems controlling the inhibition of heroin seeking
-
批准号:10676200
-
项目类别:
-
资助金额:$42.38万
-
财政年份:2019
-
负责人:RYAN T LALUMIERE
-
依托单位:
Neural systems controlling the inhibition of heroin seeking
-
批准号:10391777
-
项目类别:
-
资助金额:$10.74万
-
财政年份:2019
-
负责人:RYAN T LALUMIERE
-
依托单位:
Neural systems controlling the inhibition of heroin seeking
-
批准号:10025582
-
项目类别:
-
资助金额:$42.38万
-
财政年份:2019
-
负责人:RYAN T LALUMIERE
-
依托单位:
Neural systems controlling the inhibition of heroin seeking
-
批准号:10456761
-
项目类别:
-
资助金额:$42.38万
-
财政年份:2019
-
负责人:RYAN T LALUMIERE
-
依托单位:
Neural systems controlling the inhibition of heroin seeking
-
批准号:10220003
-
项目类别:
-
资助金额:$42.38万
-
财政年份:2019
-
负责人:RYAN T LALUMIERE
-
依托单位:
Neural systems controlling the inhibition of heroin seeking
-
批准号:10673236
-
项目类别:
-
资助金额:$10.74万
-
财政年份:2019
-
负责人:RYAN T LALUMIERE
-
依托单位:
Neural Pathways Modulating Memory Consolidation
-
批准号:8882716
-
项目类别:
-
资助金额:$38.75万
-
财政年份:2015
-
负责人:RYAN T LALUMIERE
-
依托单位:
Modulation of Synaptic and Behavioral Measures of Addiction by Acid-sensing Ion Channels
-
批准号:9100669
-
项目类别:
-
资助金额:$35.86万
-
财政年份:2014
-
负责人:RYAN T LALUMIERE
-
依托单位:
Modulation of Synaptic and Behavioral Measures of Addiction by Acid-sensing Ion Channels
-
批准号:8813302
-
项目类别:
-
资助金额:$35.86万
-
财政年份:2014
-
负责人:RYAN T LALUMIERE
-
依托单位:
Modulation of Synaptic and Behavioral Measures of Addiction by Acid-sensing Ion Channels
-
批准号:9518787
-
项目类别:
-
资助金额:$36.22万
-
财政年份:2014
-
负责人:RYAN T LALUMIERE
-
依托单位:
Modulation of Synaptic and Behavioral Measures of Addiction by Acid-sensing Ion Channels
-
批准号:8930129
-
项目类别:
-
资助金额:$35.32万
-
财政年份:2014
-
负责人:RYAN T LALUMIERE
-
依托单位:
Isolating the Extinction Circuit for Cocaine Seeking
-
批准号:8526758
-
项目类别:
-
资助金额:$33.25万
-
财政年份:2013
-
负责人:RYAN T LALUMIERE
-
依托单位:
Isolating the Extinction Circuit for Cocaine Seeking
-
批准号:8730109
-
项目类别:
-
资助金额:$33.35万
-
财政年份:2013
-
负责人:RYAN T LALUMIERE
-
依托单位:
Optogenetic modulation of memory consolidation for footshock-based learning
-
批准号:8443307
-
项目类别:
-
资助金额:$22.25万
-
财政年份:2012
-
负责人:RYAN T LALUMIERE
-
依托单位:
Optogenetic modulation of memory consolidation for footshock-based learning
-
批准号:8536956
-
项目类别:
-
资助金额:$17.72万
-
财政年份:2012
-
负责人:RYAN T LALUMIERE
-
依托单位:
Infralimbic Regulation of Memory Consolidation of Extinction of Cocaine-seeking
-
批准号:8077621
-
项目类别:
-
资助金额:$17.11万
-
财政年份:2009
-
负责人:RYAN T LALUMIERE
-
依托单位:
国内基金
海外基金
greenwashing behavior in China:Basedon an integrated view of reconfiguration of environmental authority and decoupling logic
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批准号:--
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项目类别:外国学者研究基金项目
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资助金额:--
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批准年份:2024
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负责人:YU BYUNGJUN
-
依托单位:
Incentive and governance schenism study of corporate green washing behavior in China: Based on an integiated view of econfiguration of environmental authority and decoupling logic
-
批准号:--
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项目类别:外国学者研究基金项目
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资助金额:--
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批准年份:2024
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负责人:YU BYUNGJUN
-
依托单位: