STATE MEDICAL CANNABIS LAWS, CHRONIC PAIN, AND OPIOIDS: A MIXED-METHODS APPROACH

国家医用大麻法、慢性疼痛和阿片类药物：混合方法

• 批准号: 10609894
• 负责人: Emma Elizabeth McGinty
• 金额: $ 58.61万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609894
• 关键词: Adult; Affect; Amendment; Anticonvulsants; Arthritis; Attitude; Behavior; Cannabis; Cannabis policy; Certification; Clinical; Data; Data Sources; Dryness; Effectiveness; Environment; Fees; Guidelines; Headache; Healthcare; Healthcare Systems; Individual; Interview; Laws; Lead; Literature; Location; Low Back Pain; Medical; Medical Marijuana; Medicare; Medicare claim; Methods; Opioid; Opioid Rotation; Outcome; Overdose; Pain; Pain management; Patients; Pattern; Perception; Persons; Physical therapy; Physicians; Plant Leaves; Poisoning; Policies; Policy Maker; Primary Care Physician; Quasi-experiment; Recommendation; Reporting; Research; Role; Sales; Sampling; Societies; Specialist; Surveys; Time; Variant; arthritic pain; chronic pain; chronic pain management; chronic pain patient; clinical care; cohort; comparison group; cost; design; evidence base; experience; fibromyalgia pain; innovation; insight; marijuana use; marijuana use disorder; marijuana user; medical examination; non-cancer chronic pain; non-opioid analgesic; opioid epidemic; opioid overdose; opioid use; opioid use disorder; pain patient; painful neuropathy; pharmacologic; prescription opioid

ABSTRACT Thirty-three states and D.C. have enacted medical cannabis laws allowing patients with chronic non-cancer pain to use cannabis, when recommended by a physician, to manage their condition. Policymakers are increasingly considering state medical cannabis laws as a potential solution to the U.S. opioid crisis, with the idea that some patients may substitute cannabis in place of prescription opioids for treatment of chronic non- cancer pain and reduce rates of opioid use disorder and overdose as a result. However, rigorous evidence is lacking: no studies have examined the effects of state medical cannabis laws on opioid-related outcomes among a cohort of patients with chronic non-cancer pain. Further, no existing research has examined how state medical cannabis laws affect chronic non-cancer pain patients’ receipt of guideline-concordant non-opioid pain treatments or how such laws affect cannabis use disorder and poisoning among those with chronic non- cancer pain conditions like low back pain or arthritis. Critically, no prior studies have considered how the considerable variation in provisions and implementation across state medical cannabis laws, and within states over time as states amend their laws and change implementation rules, affect outcomes for chronic pain patients. Our study uses a mixed-methods approach incorporating quasi-experimental difference-in-differences analyses; qualitative interviews with state policy and healthcare leaders; and representative surveys of physicians who treat and patients who experience chronic non-cancer pain to fill these research gaps. Using 50-state data sources including Medicare and Optum UnitedHealthcare administrative claims data, we will examine the effects of state medical cannabis laws on receipt of prescription opioid and guideline-concordant non-opioid pharmacologic (e.g., anticonvulsants) and non-pharmacologic (e.g., physical therapy) pain treatments (Aim 1). We will also use these data to examine the effects of state medical cannabis laws on receipt of treatment for opioid use disorder, opioid overdose, cannabis use disorder, and cannabis poisoning among patients with chronic non-cancer pain (Aim 2). We will conduct qualitative interviews with state policy and healthcare system leaders to characterize implementation of state medical cannabis laws for treatment of chronic non-cancer pain (Aim 3). Finally, we will conduct representative surveys with primary care physicians, pain specialists, and patients with chronic non-cancer pain in states with medical cannabis laws. Surveys will capture key attitudes and reported behaviors related to medical cannabis laws, including the degree to which physicians report recommending and patients report using cannabis in place of opioids for treatment of chronic non-cancer pain (Aim 4). In all Aims, we will consider how differences in law provisions and implementation influence chronic pain treatment. Results will yield information needed by state decision-makers considering implementing new medical cannabis laws as well as those considering changes to existing medical cannabis laws’ provisions and implementation.

摘要

项目成果

The state of the evidence on the association between state cannabis laws and opioid-related outcomes: A review.

• DOI: 10.1007/s40429-021-00397-1
• 发表时间: 2021-12
• 期刊: CURRENT ADDICTION REPORTS
• 影响因子: 4.3
• 作者: Tormohlen, Kayla N;Bicket, Mark C;White, Sarah;Barry, Colleen L;Stuart, Elizabeth A;Rutkow, Lainie;McGinty, Emma E
• 通讯作者: McGinty, Emma E

Perceived Safety and Effectiveness of Cannabis and Other Types of Pain Treatments Among Adults with Chronic Noncancer Pain in U.S. States with Medical Cannabis Programs.

美国各州开展医用大麻计划的慢性非癌性疼痛成人对大麻和其他类型疼痛治疗的安全性和有效性的认知。

• DOI: 10.1007/s11606-023-08163-x
• 发表时间: 2023
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: White,SarahA;Bicket,MarkC;McGinty,EmmaE
• 通讯作者: McGinty,EmmaE

Patient Responses to Surgery-relevant Screening for Opioid and Other Risky Substance Use Before Surgery: A Pretest-posttest Study.

患者对术前阿片类药物和其他危险物质使用的手术相关筛查的反应：一项前后测试研究。

• DOI: 10.1093/pm/pnac190
• 发表时间: 2023
• 期刊: Pain medicine (Malden, Mass.)
• 作者: Fernandez,AnneC;Aslesen,Heidi;Golmirzaie,Goodardz;Stanton,Sofea;Gunaseelan,Vidhya;Waljee,Jennifer;Brummett,ChadM;Englesbe,Michael;Bicket,MarkC
• 通讯作者: Bicket,MarkC

Use of Cannabis and Other Pain Treatments Among Adults With Chronic Pain in US States With Medical Cannabis Programs.

• DOI: 10.1001/jamanetworkopen.2022.49797
• 发表时间: 2023-01-03
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Bicket, Mark C.;Stone, Elizabeth M.;McGinty, Emma E.
• 通讯作者: McGinty, Emma E.

Protocol: mixed-methods study of how implementation of US state medical cannabis laws affects treatment of chronic non-cancer pain and adverse opioid outcomes.

• DOI: 10.1186/s13012-020-01071-2
• 发表时间: 2021-01-07
• 期刊: Implementation science : IS
• 作者: McGinty EE;Tormohlen KN;Barry CL;Bicket MC;Rutkow L;Stuart EA
• 通讯作者: Stuart EA