STATE MEDICAL CANNABIS LAWS, CHRONIC PAIN, AND OPIOIDS: A MIXED-METHODS APPROACH
国家医用大麻法、慢性疼痛和阿片类药物:混合方法
基本信息
- 批准号:10609894
- 负责人:
- 金额:$ 58.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAmendmentAnticonvulsantsArthritisAttitudeBehaviorCannabisCannabis policyCertificationClinicalDataData SourcesDrynessEffectivenessEnvironmentFeesGuidelinesHeadacheHealthcareHealthcare SystemsIndividualInterviewLawsLeadLiteratureLocationLow Back PainMedicalMedical MarijuanaMedicareMedicare claimMethodsOpioidOpioid RotationOutcomeOverdosePainPain managementPatientsPatternPerceptionPersonsPhysical therapyPhysiciansPlant LeavesPoisoningPoliciesPolicy MakerPrimary Care PhysicianQuasi-experimentRecommendationReportingResearchRoleSalesSamplingSocietiesSpecialistSurveysTimeVariantarthritic painchronic painchronic pain managementchronic pain patientclinical carecohortcomparison groupcostdesignevidence baseexperiencefibromyalgia paininnovationinsightmarijuana usemarijuana use disordermarijuana usermedical examinationnon-cancer chronic painnon-opioid analgesicopioid epidemicopioid overdoseopioid useopioid use disorderpain patientpainful neuropathypharmacologicprescription opioid
项目摘要
ABSTRACT
Thirty-three states and D.C. have enacted medical cannabis laws allowing patients with chronic non-cancer
pain to use cannabis, when recommended by a physician, to manage their condition. Policymakers are
increasingly considering state medical cannabis laws as a potential solution to the U.S. opioid crisis, with the
idea that some patients may substitute cannabis in place of prescription opioids for treatment of chronic non-
cancer pain and reduce rates of opioid use disorder and overdose as a result. However, rigorous evidence is
lacking: no studies have examined the effects of state medical cannabis laws on opioid-related outcomes
among a cohort of patients with chronic non-cancer pain. Further, no existing research has examined how
state medical cannabis laws affect chronic non-cancer pain patients’ receipt of guideline-concordant non-opioid
pain treatments or how such laws affect cannabis use disorder and poisoning among those with chronic non-
cancer pain conditions like low back pain or arthritis. Critically, no prior studies have considered how the
considerable variation in provisions and implementation across state medical cannabis laws, and within states
over time as states amend their laws and change implementation rules, affect outcomes for chronic pain
patients. Our study uses a mixed-methods approach incorporating quasi-experimental difference-in-differences
analyses; qualitative interviews with state policy and healthcare leaders; and representative surveys of
physicians who treat and patients who experience chronic non-cancer pain to fill these research gaps. Using
50-state data sources including Medicare and Optum UnitedHealthcare administrative claims data, we will
examine the effects of state medical cannabis laws on receipt of prescription opioid and guideline-concordant
non-opioid pharmacologic (e.g., anticonvulsants) and non-pharmacologic (e.g., physical therapy) pain
treatments (Aim 1). We will also use these data to examine the effects of state medical cannabis laws on
receipt of treatment for opioid use disorder, opioid overdose, cannabis use disorder, and cannabis poisoning
among patients with chronic non-cancer pain (Aim 2). We will conduct qualitative interviews with state policy
and healthcare system leaders to characterize implementation of state medical cannabis laws for treatment of
chronic non-cancer pain (Aim 3). Finally, we will conduct representative surveys with primary care physicians,
pain specialists, and patients with chronic non-cancer pain in states with medical cannabis laws. Surveys will
capture key attitudes and reported behaviors related to medical cannabis laws, including the degree to which
physicians report recommending and patients report using cannabis in place of opioids for treatment of chronic
non-cancer pain (Aim 4). In all Aims, we will consider how differences in law provisions and implementation
influence chronic pain treatment. Results will yield information needed by state decision-makers considering
implementing new medical cannabis laws as well as those considering changes to existing medical cannabis
laws’ provisions and implementation.
摘要
33个州和华盛顿特区颁布了医用大麻法,允许慢性非癌症患者
疼痛使用大麻,当医生建议,以管理他们的病情。决策者
越来越多地考虑将州医用大麻法作为美国阿片类药物危机的潜在解决方案,
一些患者可能会用大麻代替处方阿片类药物来治疗慢性非阿片类药物,
癌症疼痛,并因此降低阿片类药物使用障碍和过量的比率。然而,严格的证据表明,
缺乏:没有研究检查了州医用大麻法对阿片类药物相关结果的影响
在一组慢性非癌症疼痛患者中。此外,没有现有的研究已经研究了如何
国家医用大麻法律影响慢性非癌症疼痛患者接受指南一致的非阿片类药物
疼痛治疗或这些法律如何影响大麻使用障碍和中毒的慢性非-
癌症疼痛状况,如腰痛或关节炎。重要的是,以前的研究没有考虑到
各州医用大麻法律的规定和实施情况以及各州内部的规定和实施情况存在相当大的差异,
随着时间的推移,随着各州修改法律和改变实施规则,
患者我们的研究采用了混合方法的方法,将准实验差异中的差异
分析;与国家政策和医疗保健领导人的定性访谈;以及
治疗的医生和经历慢性非癌症疼痛的患者来填补这些研究空白。使用
50-州数据源,包括Medicare和Optum UnitedHealthcare行政索赔数据,我们将
检查州医用大麻法律对接受处方阿片类药物和指南一致性的影响
非阿片样物质药理学(例如,抗惊厥药)和非药物(例如,物理治疗)疼痛
治疗(目标1)。我们还将使用这些数据来研究州医用大麻法律对
接受阿片类药物使用障碍、阿片类药物过量、大麻使用障碍和大麻中毒治疗
慢性非癌性疼痛患者(目标2)。我们将对国家政策进行定性采访
和医疗保健系统的领导人,以确定国家医用大麻法的实施情况,
慢性非癌性疼痛(目标3)。最后,我们将对初级保健医生进行有代表性的调查,
疼痛专家,以及在有医用大麻法律的州患有慢性非癌症疼痛的患者。调查将
捕获与医用大麻法律相关的关键态度和报告的行为,包括
医生报告建议和患者报告使用大麻代替阿片类药物治疗慢性
非癌性疼痛(目标4)。在所有目标中,我们将考虑法律规定和执行的差异
影响慢性疼痛治疗。结果将产生国家决策者所需的信息,
实施新的医用大麻法律以及考虑改变现有医用大麻的法律
法律的规定和实施。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The state of the evidence on the association between state cannabis laws and opioid-related outcomes: A review.
- DOI:10.1007/s40429-021-00397-1
- 发表时间:2021-12
- 期刊:
- 影响因子:4.3
- 作者:Tormohlen, Kayla N;Bicket, Mark C;White, Sarah;Barry, Colleen L;Stuart, Elizabeth A;Rutkow, Lainie;McGinty, Emma E
- 通讯作者:McGinty, Emma E
Perceived Safety and Effectiveness of Cannabis and Other Types of Pain Treatments Among Adults with Chronic Noncancer Pain in U.S. States with Medical Cannabis Programs.
美国各州开展医用大麻计划的慢性非癌性疼痛成人对大麻和其他类型疼痛治疗的安全性和有效性的认知。
- DOI:10.1007/s11606-023-08163-x
- 发表时间:2023
- 期刊:
- 影响因子:5.7
- 作者:White,SarahA;Bicket,MarkC;McGinty,EmmaE
- 通讯作者:McGinty,EmmaE
Patient Responses to Surgery-relevant Screening for Opioid and Other Risky Substance Use Before Surgery: A Pretest-posttest Study.
患者对术前阿片类药物和其他危险物质使用的手术相关筛查的反应:一项前后测试研究。
- DOI:10.1093/pm/pnac190
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Fernandez,AnneC;Aslesen,Heidi;Golmirzaie,Goodardz;Stanton,Sofea;Gunaseelan,Vidhya;Waljee,Jennifer;Brummett,ChadM;Englesbe,Michael;Bicket,MarkC
- 通讯作者:Bicket,MarkC
Use of Cannabis and Other Pain Treatments Among Adults With Chronic Pain in US States With Medical Cannabis Programs.
- DOI:10.1001/jamanetworkopen.2022.49797
- 发表时间:2023-01-03
- 期刊:
- 影响因子:13.8
- 作者:Bicket, Mark C.;Stone, Elizabeth M.;McGinty, Emma E.
- 通讯作者:McGinty, Emma E.
Protocol: mixed-methods study of how implementation of US state medical cannabis laws affects treatment of chronic non-cancer pain and adverse opioid outcomes.
- DOI:10.1186/s13012-020-01071-2
- 发表时间:2021-01-07
- 期刊:
- 影响因子:0
- 作者:McGinty EE;Tormohlen KN;Barry CL;Bicket MC;Rutkow L;Stuart EA
- 通讯作者:Stuart EA
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Emma Elizabeth McGinty其他文献
Emma Elizabeth McGinty的其他文献
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{{ truncateString('Emma Elizabeth McGinty', 18)}}的其他基金
State Medical Cannabis Laws, Chronic Pain, and Opioids: A Mixed-Methods Approach
州医用大麻法、慢性疼痛和阿片类药物:混合方法
- 批准号:
10199994 - 财政年份:2020
- 资助金额:
$ 58.61万 - 项目类别:
STATE MEDICAL CANNABIS LAWS, CHRONIC PAIN, AND OPIOIDS: A MIXED-METHODS APPROACH
国家医用大麻法、慢性疼痛和阿片类药物:混合方法
- 批准号:
10748731 - 财政年份:2020
- 资助金额:
$ 58.61万 - 项目类别:
State Medical Cannabis Laws, Chronic Pain, and Opioids: A Mixed-Methods Approach
州医用大麻法、慢性疼痛和阿片类药物:混合方法
- 批准号:
10392504 - 财政年份:2020
- 资助金额:
$ 58.61万 - 项目类别:
Using an innovative quality improvement process to increase delivery of evidenced-based CVD risk factor care in community mental health organizations
使用创新的质量改进流程来增加社区精神卫生组织中基于证据的 CVD 危险因素护理的提供
- 批准号:
10188641 - 财政年份:2018
- 资助金额:
$ 58.61万 - 项目类别:
Mental Health Services and Systems Training Program
心理健康服务和系统培训计划
- 批准号:
10187652 - 财政年份:2017
- 资助金额:
$ 58.61万 - 项目类别:
An Evaluation of State Laws Intended to Curb High-Risk Opioid Prescribing
对旨在遏制高风险阿片类药物处方的州法律的评估
- 批准号:
9421929 - 财政年份:2017
- 资助金额:
$ 58.61万 - 项目类别:
Improving Evidence-based Behavioral, Somatic and Social Service Delivery for SMI
改善 SMI 的循证行为、躯体和社会服务交付
- 批准号:
9032165 - 财政年份:2015
- 资助金额:
$ 58.61万 - 项目类别:
Improving Evidence-based Behavioral, Somatic and Social Service Delivery for SMI
改善 SMI 的循证行为、躯体和社会服务交付
- 批准号:
9144866 - 财政年份:2015
- 资助金额:
$ 58.61万 - 项目类别:
Improving Evidence-based Behavioral, Somatic and Social Service Delivery for SMI
改善 SMI 的循证行为、躯体和社会服务交付
- 批准号:
9339398 - 财政年份:2015
- 资助金额:
$ 58.61万 - 项目类别:
Using an innovative quality improvement process to increase delivery of evidenced-based CVD risk factor care in community mental health organizations
使用创新的质量改进流程来增加社区精神卫生组织中基于证据的 CVD 危险因素护理的提供
- 批准号:
9762201 - 财政年份:
- 资助金额:
$ 58.61万 - 项目类别:
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