Culture-Gene Relationship: A Novel Model of Aging Cognitive Health
文化与基因的关系:老龄化认知健康的新模型
基本信息
- 批准号:9311065
- 负责人:
- 金额:$ 41.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-01 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:African AmericanAgeAgingAllelesAlzheimer&aposs DiseaseAlzheimer&aposs disease riskApolipoproteinsAutopsyBaltimoreBehavioral MechanismsBeliefBiological MarkersCognitionCognitiveCognitive agingCognitive deficitsDataData SetDementiaDiagnosisDiscriminationDiseaseDisease modelElderlyEnvironmental Risk FactorFeelingFibrinogenGenesGenotypeHealthHealth StatusHealth and Retirement StudyHippocampus (Brain)Impaired cognitionIndividualInterventionInvestigationLeadLinkLongevityLongitudinal StudiesMagnetic Resonance ImagingMeasuresMediator of activation proteinMental DepressionModelingNational Institute on AgingNeurofibrillary TanglesOutcomePatternPhysical activityPolicy MakerPredispositionPrevalencePsychosocial FactorRaceResearchRiskScientistSenile PlaquesStereotypingStressSusceptibility GeneTestingTimeVeteransWomanapolipoprotein E-4basecognitive performanceexperiencegenetic risk factorimprovedlongitudinal datasetmembermenmild cognitive impairmentnovelprimary outcomepsychologicpsychosocialracial disparityresiliencesecondary outcomesextheoriesyoung adult
项目摘要
Abstract
To reduce the prevalence of Alzheimer's disease (AD), scientists and policy makers have called for new
models of the disease. The proposed project tests a novel model of how culture and genes may interact to
influence AD and cognitive health. This project will provide the first investigation of whether a modifiable,
culture-based environmental factor, negative age beliefs, exacerbates the effect of the genetic-risk-factor
apolipoprotein E4 (APOE ε4) on adverse cognitive outcomes, including risk for AD, and whether positive age
beliefs increase the likelihood that APOE ε2 leads to beneficial cognitive outcomes, including reduced AD risk.
The proposed project builds on our findings with older individuals that (a) negative age beliefs can lead to
greater stress, worse cognitive outcomes, and a greater accumulation of AD biomarkers; and (b) positive age
beliefs can protect against these outcomes. This project also builds on the finding that APOE ε4 and ε2
account for less than half of aging-cognition variance; age beliefs may help to explain the remaining variance.
Our proposed project with older persons will examine four specific aims for the first time:
Aim 1. To examine whether the APOE genotype moderates age beliefs' impact on cognitive outcomes. We
predict: (a) APOE ε4 carriers will show a greater detrimental impact of negative age beliefs on cognitive
outcomes, compared to non-APOE ε4 carriers; and (b) APOE ε2 carriers will show a greater beneficial impact
of positive age beliefs on cognitive outcomes, compared to non-APOE ε2 carriers.
Aim 2. To examine whether our age belief-APOE genotype model helps to explain disparities by race and sex
on cognitive outcomes. Considering that members of marginalized groups may be more sensitive to age
stereotypes, we predict: (a) African Americans will show a stronger additive influence of APOE ε4 and negative
age beliefs on detrimental cognitive outcomes, as well as a stronger additive influence of APOE ε2 and positive
age beliefs on beneficial cognitive outcome, compared to Whites; and (b) women, compared to men, will show
the same pattern as older African Americans described in Aim 2a.
Aim 3. To examine whether psychosocial factors, related to age beliefs, influence Aim 1 patterns. We predict:
(a) those higher in vulnerability factors (e.g., perceived discrimination) will show a stronger additive influence of
APOE ε4 and negative age beliefs on detrimental cognitive outcomes, as well as a weaker additive influence of
APOE ε2 and positive age beliefs on beneficial cognitive outcomes; and (b) those higher in resiliency factors
(e.g., feeling useful to others) will show the reverse pattern.
Aim 4. To examine whether psychological and behavioral mechanisms link the age belief-genotype predictor
to cognitive outcomes. We predict: stress and physical activity will act as mediators of this association.
This proposed project will draw on three longitudinal datasets with common key variables. This study
meets the NIA priority to identify factors that could help explain disparities in AD risk by race and sex.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
BECCA R LEVY其他文献
BECCA R LEVY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('BECCA R LEVY', 18)}}的其他基金
Administrative Supplement to Cognitive Resilience among Older Samoans
老年萨摩亚人认知弹性的行政补充
- 批准号:
10773593 - 财政年份:2021
- 资助金额:
$ 41.88万 - 项目类别:
Stress Biomarkers as a Potential Link Between Age Beliefs and Health
压力生物标志物是年龄信念与健康之间的潜在联系
- 批准号:
8929104 - 财政年份:2014
- 资助金额:
$ 41.88万 - 项目类别:
Stress Biomarkers as a Potential Link Between Age Beliefs and Health
压力生物标志物是年龄信念与健康之间的潜在联系
- 批准号:
8697840 - 财政年份:2014
- 资助金额:
$ 41.88万 - 项目类别:
Positive Age Stereotypes Across the LifeSpan
整个生命周期中积极的年龄刻板印象
- 批准号:
7649694 - 财政年份:2009
- 资助金额:
$ 41.88万 - 项目类别:
Positive Age Stereotypes Across the LifeSpan
整个生命周期中积极的年龄刻板印象
- 批准号:
7896773 - 财政年份:2009
- 资助金额:
$ 41.88万 - 项目类别:
Racial Disparities in Heart Attack Recovery: Role of Stress and Stigma
心脏病康复中的种族差异:压力和耻辱的作用
- 批准号:
7880003 - 财政年份:2008
- 资助金额:
$ 41.88万 - 项目类别:
Racial Disparities in Heart Attack Recovery: Role of Stress and Stigma
心脏病康复中的种族差异:压力和耻辱的作用
- 批准号:
7464360 - 财政年份:2008
- 资助金额:
$ 41.88万 - 项目类别:
Racial Disparities in Heart Attack Recovery: Role of Stress and Stigma
心脏病康复中的种族差异:压力和耻辱的作用
- 批准号:
8102893 - 财政年份:2008
- 资助金额:
$ 41.88万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
The Phenomenon of Stem Cell Aging according to Methylation Estimates of Age After Hematopoietic Stem Cell Transplantation
根据造血干细胞移植后甲基化年龄估算干细胞衰老现象
- 批准号:
23K07844 - 财政年份:2023
- 资助金额:
$ 41.88万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of Age-dependent Functional Changes in Skeletal Muscle CB1 Receptors by an in Vitro Model of Aging-related Muscle Atrophy
通过衰老相关性肌肉萎缩的体外模型分析骨骼肌 CB1 受体的年龄依赖性功能变化
- 批准号:
22KJ2960 - 财政年份:2023
- 资助金额:
$ 41.88万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Joint U.S.-Japan Measures for Aging and Dementia Derived from the Prevention of Age-Related and Noise-induced Hearing Loss
美日针对预防与年龄相关和噪声引起的听力损失而导致的老龄化和痴呆症联合措施
- 批准号:
23KK0156 - 财政年份:2023
- 资助金额:
$ 41.88万 - 项目类别:
Fund for the Promotion of Joint International Research (International Collaborative Research)
The Effects of Muscle Fatigability on Gait Instability in Aging and Age-Related Falls Risk
肌肉疲劳对衰老步态不稳定性和年龄相关跌倒风险的影响
- 批准号:
10677409 - 财政年份:2023
- 资助金额:
$ 41.88万 - 项目类别:
Characterizing gut physiology by age, frailty, and sex: assessing the role of the aging gut in "inflamm-aging"
按年龄、虚弱和性别表征肠道生理学特征:评估衰老肠道在“炎症衰老”中的作用
- 批准号:
497927 - 财政年份:2023
- 资助金额:
$ 41.88万 - 项目类别:
Role of AGE/RAGEsignaling as a driver of pathological aging in the brain
AGE/RAGE信号传导作为大脑病理性衰老驱动因素的作用
- 批准号:
10836835 - 财政年份:2023
- 资助金额:
$ 41.88万 - 项目类别:
Deciphering the role of osteopontin in the aging eye and age-related macular degeneration
破译骨桥蛋白在眼睛老化和年龄相关性黄斑变性中的作用
- 批准号:
10679287 - 财政年份:2023
- 资助金额:
$ 41.88万 - 项目类别:
Elucidation of the protein kinase NLK-mediated aging mechanisms and treatment of age-related diseases
阐明蛋白激酶NLK介导的衰老机制及年龄相关疾病的治疗
- 批准号:
23K06378 - 财政年份:2023
- 资助金额:
$ 41.88万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Underlying mechanisms of age-related changes in ingestive behaviors: From the perspective of the aging brain and deterioration of the gustatory system.
与年龄相关的摄入行为变化的潜在机制:从大脑老化和味觉系统退化的角度来看。
- 批准号:
23K10845 - 财政年份:2023
- 资助金额:
$ 41.88万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Targeting Age-Activated Proinflammatory Chemokine Signaling by CCL2/11 to Enhance Skeletal Muscle Regeneration in Aging
通过 CCL2/11 靶向年龄激活的促炎趋化因子信号传导以增强衰老过程中的骨骼肌再生
- 批准号:
478877 - 财政年份:2023
- 资助金额:
$ 41.88万 - 项目类别:
Operating Grants