Experimental Pathology Research Laboratory Shared Resource

摘要/项目摘要 实验病理学共享资源(ExpPath) 实验病理学共享资源(ExpPath)的使命是提供高质量的- 受控、一致、可靠和经济高效的服务，用于组织病理学分析 人类肿瘤和实验动物癌症模型。每年，60多名珀尔穆特癌症患者 中心(PCC)主要研究人员，从初级教员到霍华德·休斯 调查人员，使用ExpPath，它从一开始就得到了我们CCSG的支持。 自2005年以来，该实验室在生物标记物领域显著扩展了服务组合。 化验和组织成像。在Cynthia Loomis博士的指导下，ExpPath充当 以组织为基础的翻译研究工作流程中的中心中心，独特地定位为 湿法实验室和临床之间的“桥梁”。它通过以下方式完成其使命 四个具体目标的手段：目的1)协助PCC调查人员在分子和 为正常组织和病变组织的形态特征提供相关的科学依据 专业知识和技术支持；目标2)培训组织制备、生物标记物方面的研究人员 检测和分析；目标3)引入尖端技术和新方法 对完整组织的原位讯问；以及目标4)加快翻译研究，包括 具有共同生物医学兴趣的临床研究人员和基础科学家。

Abstract/Project Summary Experimental Pathology Shared Resource (ExpPath) The mission of the Experimental Pathology Shared Resource (ExpPath) is to provide quality- controlled, consistent, reliable, and cost-effective services for the histopathologic analysis of human tumors and experimental animal cancer models. Every year, over 60 Perlmutter Cancer Center (PCC) principal investigators, ranging from starting faculty to Howard Hughes investigators, utilize ExpPath, which has been supported by our CCSG since its inception. Since 2005 the lab has expanded the service portfolio significantly in the areas of biomarker assays and tissue imaging. Under the direction of Dr. Cynthia Loomis, ExpPath serves as a central hub in the workflow of tissue-based translational research, uniquely positioned as a “bridge” between the wet-bench research laboratory and the clinic. It achieves its mission by means of four Specific Aims: Aim 1) To assist PCC investigators in the molecular and morphologic characterization of normal and diseased tissues by providing relevant scientific expertise and technical support; Aim 2) To train investigators in tissue preparation, biomarker detection and analysis; Aim 3) To introduce cutting-edge technology and novel approaches for in situ interrogation of intact tissues; and Aim 4) To expedite translational research involving clinical investigators and basic scientists with shared biomedical interests.