Effects of the DASH diet on glucose patterns in adults with type 2 diabetes

摘要 拟议的拨款是一项已获批准的辅助研究，以饮食方法来阻止高血压， 糖尿病试验（DASH4D），一项在约翰霍普金斯大学进行的随机临床试验。的 本辅助研究的总体目标是评价控制饮食（作为本喂养研究的一部分） 改变2型糖尿病黑人和白色成人的血糖控制和血糖变异性。客观 DASH4D试验的目的是确定（a）DASH4D饮食（一种DASH式饮食）单独和组合的效果， 2型糖尿病患者的改良饮食）与许多美国人典型的对照饮食（B） 2型糖尿病患者中低钠摄入量与高钠摄入量对血压的影响， 血压升高核心设计是一项单中心、4阶段、交叉喂养研究， 时期受试者将以随机顺序喂食四种等热量饮食。拟议的辅助研究将 在所有参与者中增加连续葡萄糖监测和补充生物标志物的实验室检测， DASH4D试验在四个喂养期的每一个的两周期间进行。我们的首要目标是回答 问题：富含水果和蔬菜的饮食是否能改善血糖控制并降低血糖变异性， 2型糖尿病的治疗方法

Abstract The proposed grant is an approved ancillary study to the Dietary Approaches to Stop Hypertension for Diabetes Trial (DASH4D), a randomized clinical trial being conducted at Johns Hopkins University. The overarching goal of this ancillary study is to evaluate how a controlled diet (as part of this feeding study) modifies glucose control and glycemic variability in black and white adults with type 2 diabetes. The objective of the DASH4D trial is to determine the effects, alone and combined, of (a) the DASH4D diet (a DASH-style diet modified for people with type 2 diabetes) vs. comparison diet typical of what many Americans eat and (b) lower sodium intake vs. higher sodium intake on blood pressure among people with type 2 diabetes and elevated blood pressure. The core design is a single-site, 4-period, crossover feeding study with 5-week periods. Participants will be fed each of four isocaloric diets in random order. The proposed ancillary study will add continuous glucose monitoring and laboratory testing of complementary biomarkers in all participants in the DASH4D trial during two weeks of each of the four feeding periods. Our overarching goal is to answer the question: Does a diet rich in fruits and vegetables improve glucose control and reduce glycemic variability in adults with type 2 diabetes?