Research and Mentoring in the Clinical Epidemiology of Cardiovascular Disease and Type 2 Diabetes

心血管疾病和 2 型糖尿病的临床流行病学研究和指导

• 批准号: 10613536
• 负责人: Elizabeth Selvin
• 金额: $ 12.24万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10613536
• 关键词: Acute; Address; Appointment; Area; Award; Biological Markers; Biometry; Blood Vessels; Budgets; Cardiac; Cardiology; Cardiovascular Diseases; Cardiovascular system; Caring; Cessation of life; Chronic; Circulation; Clinical; Clinical Chemistry; Clinical Research; Cognitive; Collaborations; Dedications; Diabetes Mellitus; Discipline of Nursing; Doctor of Philosophy; Educational Status; Elderly; Endocrinology; Environment; Epidemiologic Methods; Epidemiology; Faculty; Funding; Genomics; Goals; Grant; Health; Health Promotion; Hyperglycemia; Imaging technology; Impairment; Internal Medicine; Journals; K-Series Research Career Programs; Knowledge; Manuscripts; Master of Science; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Monitor; Morbidity - disease rate; Neurology; Non-Insulin-Dependent Diabetes Mellitus; Persons; Pilot Projects; Prediabetes syndrome; Prevention; Prevention Research; Proteomics; Public Health; Public Health Schools; Publications; Publishing; Research; Research Methodology; Research Personnel; Research Project Grants; Risk; Role; School Nursing; Scientific Advances and Accomplishments; Scientist; Serum; Talents; Time; Training; Training Activity; Translational Research; United States National Institutes of Health; cardiometabolism; cardiovascular disorder epidemiology; cardiovascular disorder prevention; cardiovascular risk factor; career; career development; clinical decision-making; clinical epidemiology; collaborative environment; design; disorder prevention; epidemiology study; evidence base; faculty mentor; improved; medical schools; member; mortality; multidisciplinary; next generation; novel; optimal treatments; patient oriented; patient oriented research; prevent; programs; randomized, clinical trials; recruit; screening; success; tool

Cardiovascular disease and type 2 diabetes are major public health concerns, particularly in older adults. There are major gaps in our knowledge about diabetes and how to prevent its associated microvascular and cardiovascular complications. In older adults, there is controversy regarding the total burden of risk associated with diabetes and prediabetes, optimal treatment targets, and how best to reduce cardiovascular risk and prevent cognitive and physical impairment. Novel cardiac biomarkers reflect the summation of acute and chronic morbidity and may have utility for informing treatment decisions in diabetes and other cardiometabolic conditions, but they have not been rigorously evaluated. To address these issues, we need junior patient- oriented investigators who will need rigorous training and mentorship in the areas of clinical epidemiology, translational research methods, and the conduct of large clinical studies. The candidate, Elizabeth Selvin, PhD, MPH, has devoted her career to the study of the clinical epidemiology of type 2 diabetes and cardiovascular disease and the mentorship of trainees in this field. The continuation of this K24 award will protect the time of the candidate for research and mentoring. The goals during this award are to recruit a team of diverse, multi- disciplinary junior investigators who will receive mentorship in the clinical epidemiology of cardiovascular disease and diabetes; to promote formal training in epidemiology and clinical research methods for beginning clinician investigators; and to mentor trainees to address significant research questions in the field and help launch their independent research careers. Dr. Selvin's large research portfolio (including three R01 grants) will provide a rich substrate for training and new research opportunities for mentees. Dr. Selvin has a strong track record of success in the field and in mentoring junior scientists. With continued support from this K24, she will be able to expand her mentorship activities, strengthen her research portfolio, and recruit and train the next generation of leaders in the field.

心血管疾病和2型糖尿病是主要的公共卫生问题，特别是在老年人中。 我们对糖尿病以及如何预防其相关的微血管病变和糖尿病的认识存在重大差距。 心血管并发症在老年人中，关于与糖尿病相关的风险总负担存在争议。 糖尿病和前驱糖尿病，最佳治疗目标，以及如何最好地降低心血管风险， 预防认知和身体损伤。新的心脏生物标志物反映了急性和 慢性发病率，并可能有效用，为糖尿病和其他心脏代谢疾病的治疗决策提供信息。 条件，但尚未进行严格评估。为了解决这些问题，我们需要初级病人- 面向研究者，他们需要在临床流行病学领域接受严格的培训和指导， 转化研究方法和大型临床研究的开展。候选人伊丽莎白·塞尔文博士 她的职业生涯致力于2型糖尿病和心血管疾病的临床流行病学研究。 疾病和指导这一领域的受训人员。K24奖的延续将保护 研究和指导的候选人。在这个奖项的目标是招募一个团队的多样化，多- 将接受心血管疾病临床流行病学指导的学科初级研究者 疾病和糖尿病;促进流行病学和临床研究方法的正式培训， 临床研究人员;并指导学员解决该领域的重大研究问题， 开始他们的独立研究生涯。Selvin博士的大型研究组合（包括三项R 01赠款） 将为学员提供丰富的培训和新的研究机会。塞尔文医生有一个很强的 在该领域和指导初级科学家方面取得成功的记录。在K24的持续支持下， 将能够扩大她的导师活动，加强她的研究组合，并招募和培训下一个 在该领域的领导者的一代。

项目成果

Glucagon-like peptide-1 receptor agonists and the risk of atrial fibrillation in adults with diabetes: a real-world study.

胰高血糖素样肽 1 受体激动剂与成人糖尿病患者心房颤动的风险：一项真实世界研究。

• DOI: 10.1007/s11606-023-08589-3
• 发表时间: 2024
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Xu,Yunwen;Boyle,ThomasA;Lyu,Beini;Ballew,ShoshanaH;Selvin,Elizabeth;Chang,AlexanderR;Inker,LesleyA;Grams,MorganE;Shin,Jung-Im
• 通讯作者: Shin,Jung-Im

Correction to: Trends in Use of Sulfonylurea Types Among US Adults with Diabetes: NHANES 1999-2020.

更正：美国成人糖尿病患者使用磺酰脲类药物的趋势：NHANES 1999-2020。

• DOI: 10.1007/s11606-023-08445-4
• 发表时间: 2023
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Shin,Jung-Im;Echouffo-Tcheugui,JustinB;Fang,Michael;Grams,MorganE;Selvin,Elizabeth
• 通讯作者: Selvin,Elizabeth

Prevalence of Type 1 Diabetes Among US Children and Adults by Age, Sex, Race, and Ethnicity.

按年龄、性别、种族和民族划分的美国儿童和成人 1 型糖尿病患病率。

• DOI: 10.1001/jama.2024.2103
• 发表时间: 2024
• 期刊: JAMA
• 作者: Fang,Michael;Wang,Dan;Selvin,Elizabeth
• 通讯作者: Selvin,Elizabeth

Myocardial Injury Thresholds for 4 High-Sensitivity Troponin Assays in U.S. Adults.

• DOI: 10.1016/j.jacc.2023.03.403
• 发表时间: 2023-05-23
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
• 影响因子: 24
• 作者: McEvoy, John W.;Tang, Olive;Wang, Dan;Ndumele, Chiadi E.;Coresh, Josef;Christenson, Robert H.;Selvin, Elizabeth
• 通讯作者: Selvin, Elizabeth

Interpreting global trends in type 2 diabetes complications and mortality.

• DOI: 10.1007/s00125-021-05585-2
• 发表时间: 2022-01
• 期刊: Diabetologia
• 影响因子: 8.2
• 作者: Ali MK;Pearson-Stuttard J;Selvin E;Gregg EW
• 通讯作者: Gregg EW