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Clinical relevance of glucose patterns in older adults

老年人血糖模式的临床相关性

基本信息

批准号：
10361563
负责人：
Elizabeth Selvin
金额：
$ 65.9万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10361563
关键词：
Adult Age Atherosclerosis Risk in Communities Biological Markers Cardiac Cardiovascular Diseases Clinical Data Development Diabetes Mellitus Diagnosis Disease Elderly Frequencies Fructosamine Funding Future Glucose Glycosylated hemoglobin A Goals Grant Guidelines Health Health Status Homeostasis Hyperglycemia Hypoglycemia Impaired cognition Investigation Kidney Laboratories Lead Manuscripts Measurement Measures Methods Motivation Non-Insulin-Dependent Diabetes Mellitus Outcome Participant Pattern Peripheral Nervous System Diseases Persons Physical Function Physiological Population Prediabetes syndrome Quality of life Recommendation Risk Risk Factors Serum Technology Time Uncertainty Variant Visit Vulnerable Populations Work blood glucose regulation clinical practice clinically relevant cognitive function cohort evidence base follow-up frailty glucose monitor glycosylated serum albumin health related quality of life human old age (65+)mortality non-diabetic novel prognostic prospective response success virtual

项目摘要

Abstract Disordered glucose homeostasis and glucose instability are common in older adults. Age is one of the most important risk factors for the development of type 2 diabetes and there is growing evidence that glycemic variability contributes to risk of complications, independent of average glucose or HbA1c. In older adults with diabetes, there is controversy regarding appropriate treatment targets and hypoglycemia is a major concern. Continuous glucose monitoring (CGM) is the recommended approach to the assessment of hypoglycemia and glycemic variability, but this technology has rarely been used in older adults. Very old adults (age 80 years or older) are a particularly vulnerable population but have rarely been included in prior studies. Our overarching objective is to characterize glucose patterns in older adults (>80 years) using state-of-the-art CGM technology. We will characterize “normal” glucose patterns and evaluate the frequency of unrecognized glycemic excursions in adults with and without diabetes (including persons with prediabetes). We will relate glucose patterns including glucose excursions (hypo- and hyperglycemia) to current health status and clinical outcomes during 4 years of follow-up. These results will provide information on the clinical relevance of glucose patterns in an older adult population and generate evidence-based guidance regarding the use and interpretation of CGM in this population.

摘要