Examining Trauma Prevalence and Exploring Interoception as a Mechanism of Emotion Regulation in MOUD

检查创伤发生率并探索内感受作为 MOUD 情绪调节的机制

• 批准号: 10618645
• 负责人: JOSEPH O MERRILL
• 金额: $ 17.47万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-28 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10618645
• 关键词: Address; Adult; Affect; Ancillary Study; Anxiety; Awareness; Behavior Control; Behavior Therapy; Child Sexual Abuse; Clinical Trials; Communities; Complex; Data; Development; Distress; Dose; Effectiveness; Enrollment; Evidence based treatment; Funding; Future; Goals; Health; Helping to End Addiction Long-term; Individual; Interoception; Intervention; Intervention Studies; Knowledge; Learning; Learning Skill; Manuscripts; Measures; Mediating; Mediator of activation protein; Mental Depression; Mental Health; Mentorship; Military Personnel; Mind-Body Intervention; Outcome; Pain; Participant; Patients; Pharmaceutical Preparations; Post-Traumatic Stress Disorders; Prevalence; Price; Protocols documentation; Public Health; Publications; Randomized; Randomized Controlled Trials; Regulation; Relapse; Research; Research Personnel; Research Proposals; Sampling; Scientist; Severities; Substance Use Disorder; Therapeutic Studies; Training; Training and Education; Trauma; Treatment Efficacy; Treatment outcome; Violence; Washington; Well in self; Woman; Writing; base; chronic pain; clinical trial implementation; comorbidity; craving; depressive symptoms; design; disorder later incidence prevention; effectiveness evaluation; emotion regulation; evidence base; follow-up; improved; medication-assisted treatment; meetings; men; mindfulness; mindfulness intervention; non-opioid analgesic; novel; opioid epidemic; opioid use; opioid use disorder; parent grant; parent project; physical abuse; physical assault; physical conditioning; physical symptom; programs; recruit; reduced substance use; relapse risk; sexual trauma; skills; statistics; substance use; symposium; training opportunity; trauma exposure; treatment as usual; treatment research; treatment site

Project Abstract The Parent Grant (R01 AT10742; PIs Price & Merrill) is a two-group randomized controlled trial, with repeated measures, designed to enroll a sample of 330 in medication treatment for opioid use disorder (MOUD) to assess the effectiveness of Mindful Awareness in Body-oriented Therapy (MABT) as an adjunct to medication treatment for opioid use disorder (MOUD). The national opioid epidemic requires development of real-world evidence-based treatments for opioid use disorder, including adjuncts to MOUD. Interventions are needed that address the complex needs of patients with opioid use disorder, which include substantial mental health co- morbidity (e.g. PTSD, depression) and high rates of chronic pain. MABT, a novel mindfulness-based intervention, uniquely addresses aspects of awareness, interoception, and regulation that may be associated with pain, mental health distress, and behavioral control that increase risk of relapse and poor treatment outcomes. The proposed Diversity Supplement examines two critical additional research questions. The aims are: 1) to describe the types of lifetime exposure to trauma and compare types of trauma exposure between men and women engaged in MOUD, and to examine the relationship between types of trauma exposure and symptomatic distress in this sample at baseline; and 2) to explore the underlying mechanisms of MABT by examining interoceptive awareness as a possible mediator of emotion regulation difficulties and other indicators of mental health distress. It is hypothesized that emotion regulation difficulties in MABT + TAU compared to TAU only will be mediated by increased interoceptive awareness from baseline to 3-month follow- up. This application thus addresses key gaps in knowledge that are important for consideration in MOUD treatment that may be critical for reducing relapse and improving treatment outcomes.

项目摘要 父母补助（R 01 AT 10742; PI Price &梅里尔）是一项两组随机对照试验，重复 措施，旨在招募330例阿片类药物使用障碍（MOUD）药物治疗的样本， 评估身体导向疗法（MABT）中的正念意识作为药物辅助治疗的有效性 阿片类药物使用障碍（MOUD）国家阿片类药物流行病需要发展现实世界 阿片类药物使用障碍的循证治疗，包括MOUD的治疗。需要采取干预措施， 满足阿片类药物使用障碍患者的复杂需求，其中包括大量的心理健康问题， 发病率（如创伤后应激障碍，抑郁症）和慢性疼痛率高。MABT，一种新的基于正念的 干预，独特地解决了意识，内感受和调节方面，可能与 疼痛、精神健康困扰和行为控制，增加复发和治疗不良的风险 结果。拟议的多样性补充审查了两个关键的额外研究问题。目标 主要是：1）描述一生中暴露于创伤的类型，并比较 参与MOUD的男性和女性，并检查创伤暴露类型与 基线时该样本中的症状性痛苦;和2）通过以下方法探索MABT的潜在机制： 检查内感受性意识作为情绪调节困难和其他可能的中介 心理健康困扰的指标。假设MABT + TAU中的情绪调节困难 与仅TAU相比，将通过从基线至3个月随访的内感受性意识增加介导- 起来因此，该应用程序解决了在MOUD中考虑的重要知识差距 这可能是减少复发和改善治疗结果的关键。