Examining Trauma Prevalence and Exploring Interoception as a Mechanism of Emotion Regulation in MOUD
检查创伤发生率并探索内感受作为 MOUD 情绪调节的机制
基本信息
- 批准号:10618645
- 负责人:
- 金额:$ 17.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-28 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAffectAncillary StudyAnxietyAwarenessBehavior ControlBehavior TherapyChild Sexual AbuseClinical TrialsCommunitiesComplexDataDevelopmentDistressDoseEffectivenessEnrollmentEvidence based treatmentFundingFutureGoalsHealthHelping to End Addiction Long-termIndividualInteroceptionInterventionIntervention StudiesKnowledgeLearningLearning SkillManuscriptsMeasuresMediatingMediator of activation proteinMental DepressionMental HealthMentorshipMilitary PersonnelMind-Body InterventionOutcomePainParticipantPatientsPharmaceutical PreparationsPost-Traumatic Stress DisordersPrevalencePriceProtocols documentationPublic HealthPublicationsRandomizedRandomized Controlled TrialsRegulationRelapseResearchResearch PersonnelResearch ProposalsSamplingScientistSeveritiesSubstance Use DisorderTherapeutic StudiesTrainingTraining and EducationTraumaTreatment EfficacyTreatment outcomeViolenceWashingtonWell in selfWomanWritingbasechronic painclinical trial implementationcomorbiditycravingdepressive symptomsdesigndisorder later incidence preventioneffectiveness evaluationemotion regulationevidence basefollow-upimprovedmedication-assisted treatmentmeetingsmenmindfulnessmindfulness interventionnon-opioid analgesicnovelopioid epidemicopioid useopioid use disorderparent grantparent projectphysical abusephysical assaultphysical conditioningphysical symptomprogramsrecruitreduced substance userelapse risksexual traumaskillsstatisticssubstance usesymposiumtraining opportunitytrauma exposuretreatment as usualtreatment researchtreatment site
项目摘要
Project Abstract
The Parent Grant (R01 AT10742; PIs Price & Merrill) is a two-group randomized controlled trial, with repeated
measures, designed to enroll a sample of 330 in medication treatment for opioid use disorder (MOUD) to
assess the effectiveness of Mindful Awareness in Body-oriented Therapy (MABT) as an adjunct to medication
treatment for opioid use disorder (MOUD). The national opioid epidemic requires development of real-world
evidence-based treatments for opioid use disorder, including adjuncts to MOUD. Interventions are needed that
address the complex needs of patients with opioid use disorder, which include substantial mental health co-
morbidity (e.g. PTSD, depression) and high rates of chronic pain. MABT, a novel mindfulness-based
intervention, uniquely addresses aspects of awareness, interoception, and regulation that may be associated
with pain, mental health distress, and behavioral control that increase risk of relapse and poor treatment
outcomes. The proposed Diversity Supplement examines two critical additional research questions. The aims
are: 1) to describe the types of lifetime exposure to trauma and compare types of trauma exposure between
men and women engaged in MOUD, and to examine the relationship between types of trauma exposure and
symptomatic distress in this sample at baseline; and 2) to explore the underlying mechanisms of MABT by
examining interoceptive awareness as a possible mediator of emotion regulation difficulties and other
indicators of mental health distress. It is hypothesized that emotion regulation difficulties in MABT + TAU
compared to TAU only will be mediated by increased interoceptive awareness from baseline to 3-month follow-
up. This application thus addresses key gaps in knowledge that are important for consideration in MOUD
treatment that may be critical for reducing relapse and improving treatment outcomes.
项目摘要
父母补助(R 01 AT 10742; PI Price &梅里尔)是一项两组随机对照试验,重复
措施,旨在招募330例阿片类药物使用障碍(MOUD)药物治疗的样本,
评估身体导向疗法(MABT)中的正念意识作为药物辅助治疗的有效性
阿片类药物使用障碍(MOUD)国家阿片类药物流行病需要发展现实世界
阿片类药物使用障碍的循证治疗,包括MOUD的治疗。需要采取干预措施,
满足阿片类药物使用障碍患者的复杂需求,其中包括大量的心理健康问题,
发病率(如创伤后应激障碍,抑郁症)和慢性疼痛率高。MABT,一种新的基于正念的
干预,独特地解决了意识,内感受和调节方面,可能与
疼痛、精神健康困扰和行为控制,增加复发和治疗不良的风险
结果。拟议的多样性补充审查了两个关键的额外研究问题。目标
主要是:1)描述一生中暴露于创伤的类型,并比较
参与MOUD的男性和女性,并检查创伤暴露类型与
基线时该样本中的症状性痛苦;和2)通过以下方法探索MABT的潜在机制:
检查内感受性意识作为情绪调节困难和其他可能的中介
心理健康困扰的指标。假设MABT + TAU中的情绪调节困难
与仅TAU相比,将通过从基线至3个月随访的内感受性意识增加介导-
起来因此,该应用程序解决了在MOUD中考虑的重要知识差距
这可能是减少复发和改善治疗结果的关键。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOSEPH O MERRILL其他文献
JOSEPH O MERRILL的其他文献
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{{ truncateString('JOSEPH O MERRILL', 18)}}的其他基金
Mindful Body Awareness Training as an Adjunct to Medication Assisted Treatment for Opioid Use Disorder: An ancillary study
正念身体意识训练作为阿片类药物使用障碍药物辅助治疗的辅助手段:一项辅助研究
- 批准号:
9893166 - 财政年份:2019
- 资助金额:
$ 17.47万 - 项目类别:
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