The UNC/Emory Center for Innovative Technology (iTech) across the prevention and care continuum

北卡罗来纳大学/埃默里大学创新技术中心 (iTech) 涵盖预防和护理连续体

• 批准号: 10614767
• 负责人: Lisa B Hightow-Weidman
• 金额: $ 64.1万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10614767
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adherence; Adolescent; Adolescent and Young Adult; Adverse event; Age; Anal Sex; Applications Grants; Behavior; Behavioral; Cells; Clinical; Clinical Trials; Collaborations; Communities; Continuity of Patient Care; Data; Development; Dose; Drug Delivery Systems; Early identification; Early treatment; Ensure; Epidemic; Evaluable Disease; Fostering; Goals; HIV; HIV Infections; HIV diagnosis; Human immunodeficiency virus test; Infection; Infrastructure; Interdisciplinary Study; Intervention; Leadership; Link; Mental Health; Mentors; Modality; Normal saline; Oral; Persons; Pharmaceutical Preparations; Phase; Prevention; Probability; Protocols documentation; Research; Research Personnel; Resources; Risk; Safety; Scientist; Stigmatization; Technology; Tenofovir; Time; Tissues; Toxic effect; Training; United States; Vaginal Douching; Viral; Youth; age group; aged; antiretroviral therapy; base; care systems; consumer product; design; efficacy testing; experience; innovation; innovative technologies; men; men who have sex with men; microbicide; next generation; novel; open label; pharmacokinetics and pharmacodynamics; pre-exposure prophylaxis; prevention service; programs; recruit; rectal; rectal microbicide; social culture; substance use; success; synergism; technological innovation; transmission process; treatment as prevention; uptake; willingness; young men who have sex with men

While the epidemic of HIV in the US has leveled off for many age groups, from 2000-2010, the annual number of new HIV diagnoses among young men who have sex with men (YMSM) (13-24 year old) more than doubled. In 2010, YMSM accounted for 72% of new infections among people ages 13 to 24, and 30% of all new infections among MSM. The success of treatment as prevention in reducing the number of new HIV infections among youth, and particularly YMSM, relies on HIV testing, antiretroviral treatment (both for treatment and prevention), adherence and viral suppression among those with HIV. The UNC/Emory Center for Innovative Technology (iTech) aims to impact the HIV epidemic by conducting innovative, interdisciplinary research on technology-based interventions across the HIV prevention and care continuum for adolescents and young adults in the United States (US). The iTech also creates an infrastructure to share and disseminate best practices in technology-delivered HIV interventions to other ATN projects and programs serving adolescents. The iTech overall goals seek to decrease the impact of HIV on the lives of adolescents and young adults in the US, particularly YMSM, by providing: 1) treatment as prevention for those without HIV but at risk; 2) earlier identification and treatment for those infected but undiagnosed; 3) interventions to address structural determinants that decrease access to and uptake of prevention and care services; and 4) treatment interventions to encourage adherence for youth dealing with substance use, mental health related issues, stigmatization and disenfranchisement. The necessary resources and support for HIV/AIDS investigators addressing these goals will be provided by the iTech Cores: 1) Management; 2) Analytic; and, 3) Technology. To accomplish our Overall Goals we have developed the following Specific Aims: Aim 1: To provide scientific leadership with expertise and experience in technology-based research to address fundamental questions related to the HIV prevention and care continuum, guide our overall research strategy and foster collaboration and synergy both within our iTech and with the broader ATN scientific community. Aim 2: To support the development and assessment of innovative technology-focused interventions addressing the HIV prevention and care continuum for at-risk or infected youth aged 15-24 years. Aim 3: To support the overall ATN scientific agenda by participating on the ATN Executive Committee and collaborating with other U19 awardees stimulating new synergistic and responsive grants applications and research to respond to emerging issues in this field. Aim 4: To develop and nurture partnerships that will ensure community input at all stages of conceptualization, design, implementation, and interpretation of the research. Aim 5. To develop, mentor and train clinicians and researchers to stimulate innovative HIV/AIDS research focused on technological innovation across the care continuum.

虽然美国许多年龄组的艾滋病毒流行已趋于平稳，但从 2000 年到 2010 年，每年的艾滋病毒感染人数 男男性行为 (YMSM)（13-24 岁）的年轻男性中新诊断出艾滋病毒的人数超过 增加了一倍。 2010 年，YMSM 占 13 至 24 岁人群新感染病例的 72%，占所有病例的 30% MSM 中出现新感染。治疗预防在减少新发艾滋病毒感染人数方面取得了成功 青少年，特别是 YMSM 中的感染，依赖于艾滋病毒检测、抗逆转录病毒治疗（两者均用于 治疗和预防）、艾滋病毒感染者的依从性和病毒抑制。北卡罗来纳大学/埃默里中心 创新技术 (iTech) 旨在通过开展创新、跨学科的研究来影响艾滋病毒流行 对青少年艾滋病毒预防和护理连续过程中基于技术的干预措施的研究 和美国的年轻人。 iTech 还创建了一个共享和传播的基础设施 向其他 ATN 项目和计划提供技术艾滋病毒干预的最佳实践 青少年。 iTech 的总体目标旨在减少艾滋病毒对青少年和年轻人生活的影响 美国成年人，特别是 YMSM，通过提供： 1) 为那些没有艾滋病毒但处于危险中的人提供治疗作为预防； 2）对感染但未确诊的患者进行早期识别和治疗； 3）解决结构性问题的干预措施 减少获得和利用预防和护理服务的决定因素； 4) 治疗 鼓励青少年坚持处理药物滥用、心理健康相关问题的干预措施， 污名化和剥夺公民权。为艾滋病毒/艾滋病调查人员提供必要的资源和支持 iTech 核心将实现这些目标： 1) 管理； 2）分析；以及，3) 技术。 为了实现我们的总体目标，我们制定了以下具体目标： 目标 1：提供科学的 在基于技术的研究中具有解决基本问题的专业知识和经验的领导力 与艾滋病毒预防和护理连续性相关，指导我们的整体研究策略并促进合作 我们的 iTech 内部以及与更广泛的 ATN 科学界的协同作用。目标 2：支持 制定和评估以创新技术为重点的艾滋病毒干预措施 为 15-24 岁高危或受感染青少年提供连续的预防和护理。目标3：支持整体 通过参加 ATN 执行委员会并与其他 U19 合作来制定 ATN 科学议程 获奖者刺激新的协同和响应性赠款申请和研究，以应对新兴问题 该领域的问题。目标 4：发展和培育合作伙伴关系，确保社区投入 研究的概念化、设计、实施和解释阶段。目标 5. 发展、 指导和培训临床医生和研究人员，以促进创新的艾滋病毒/艾滋病研究，重点关注 整个护理过程中的技术创新。