Examining Brain Development, Context, and Culture as Mediators and Moderators of the Relation between Adverse Childhood Experiences (ACEs) and Substance (Ab)use

检查大脑发育、背景和文化作为不良童年经历 (ACE) 和药物 (Ab) 使用之间关系的中介和调节因素

• 批准号: 10618501
• 负责人: James M Bjork
• 金额: $ 5.6万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618501
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adult; Adverse effects; Affect; Alcohols; Athletic Injuries; Attitude; Behavioral; Belief; Biological; Biological Assay; Biological Markers; Biology; Brain; Brain imaging; Buffers; Caffeine; Cannabis; Child; Child Health; Childhood; Cigarette; Clinical assessments; Cognitive; Communities; Consumption; Country; Data; Data Analyses; Development; Electronic cigarette; Emotional; Enrollment; Environment; Environmental Risk Factor; Ethnic Origin; Event; Evidence based intervention; Exposure to; Family; Functional Imaging; Functional disorder; Goals; Health; Individual; Intervention; Interview; Latin American; Life; Life Cycle Stages; Longitudinal Studies; Mainstreaming; Marijuana; Mediating; Mediation; Mediator of activation protein; Mental Health; Modeling; Monitor; Nationalities; Neurocognition; Neurocognitive; Neurologic; Neuropsychological Tests; Not Hispanic or Latino; Outcome; Parents; Participant; Pathway interactions; Persons; Physical activity; Policies; Population; Positioning Attribute; Predisposition; Prevention; Prevention program; Recommendation; Research; Research Personnel; Research Project Grants; Residual state; Resource Informatics; Risk; Risk Factors; Role; Sampling; Schools; Secure; Site; Sleep; Social Functioning; Specific qualifier value; Sports; Substance abuse problem; Symptoms; Technology; Telephone; Time; Tobacco; Translating; Traumatic Brain Injury; United States; Variant; Video Games; Youth; adolescent substance use; adverse childhood events; base; behavioral outcome; brain abnormalities; cognitive development; cognitive function; cognitive testing; cultural values; emotional factor; experience; follow-up; gene interaction; improved; marginalized community; mobile application; multimodality; neural correlate; neurodevelopment; neuroimaging; physical conditioning; preadolescence; protective factors; psychosocial; relating to nervous system; research and development; retention rate; sleep pattern; social; social media; substance use; substance use prevention; temporal measurement; tv watching; vaping; young adult

PROJECT SUMMARY Adolescent Brain Cognitive Development (ABCD) is the largest long-term study of brain development and child health in the United States. The ABCD Research Consortium consists of 21 research sites across the country, a Coordinating Center, and a Data Analysis and Informatics Resource Center. In its first five years, under RFA- DA-15-015, ABCD enrolled a diverse sample of 11,878 9-10 year olds from across the consortium, and will track their biological and behavioral development through adolescence into young adulthood. All participants received a comprehensive baseline assessment, including state-of-the-art brain imaging, neuropsychological testing, bioassays, careful assessment of substance use, mental health, physical health, and culture and environment. A similar detailed assessment recurs every 2 years. Interim in-person annual interviews and mid-year telephone or mobile app assessments provide refined temporal resolution of developmental changes and life events that occur over time with minimal burden to participating youth and parents. Intensive efforts are made to keep the vast majority of participants involved with the study through adolescence and beyond, and retention rates thus far are very high. Neuroimaging has expanded our understanding of brain development from childhood into adulthood. Using this and other cutting-edge technologies, ABCD can determine how different kinds of youth experiences (such as sports, school involvement, extracurricular activities, videogames, social media, unhealthy sleep patterns, and vaping) interact with each other and with a child's changing biology to affect brain development and social, behavioral, academic, health, and other outcomes. Data, securely and privately shared with the scientific community, will enable investigators to: (1) describe individual developmental pathways in terms of neural, cognitive, emotional, and academic functioning, and influencing factors; (2) develop national standards of healthy brain development; (3) investigate the roles and interaction of genes and the environment on development; (4) examine how physical activity, sleep, screen time, sports injuries (including traumatic brain injuries), and other experiences influence brain development; (5) determine and replicate factors that influence mental health from childhood to young adulthood; (6) characterize relationships between mental health and substance use; and (7) specify how use of substances such as cannabis, alcohol, tobacco, and caffeine affects developmental outcomes, and how neural, cognitive, emotional, and environmental factors influence the risk for adolescent substance use.

项目总结 青少年大脑认知发展(ABCD)是关于大脑发育和儿童的最大的长期研究 美国的健康状况。ABCD研究联盟由全国21个研究站点组成， 一个协调中心，以及一个数据分析和信息学资源中心。在它的头五年，在RFA下- DA-15-015，ABCD从整个联盟中招募了11,878名9-10岁儿童的不同样本，并将跟踪 他们从青春期到青春期的生物和行为发育。所有参与者都收到了 全面的基线评估，包括最先进的大脑成像，神经心理测试， 生物检测，对物质使用、精神健康、身体健康以及文化和环境的仔细评估。 类似的详细评估每两年重复一次。临时年度面谈和年中电话 或移动应用程序评估提供对发展变化和生活事件的精细时间分辨率， 随着时间的推移，对参与活动的青少年和家长造成的负担最小。紧锣密鼓努力保持 绝大多数参与者在青春期及以后都参与了这项研究，因此保留率 FAR的价格非常高。神经成像扩大了我们对大脑发育的理解，从童年到 成人期。使用这项技术和其他尖端技术，ABCD可以确定不同类型的年轻人 经历(如运动、学校参与、课外活动、电子游戏、社交媒体、不健康 睡眠模式和蒸发)相互作用，并与儿童不断变化的生物学相互作用，影响大脑 发展和社会、行为、学业、健康和其他结果。安全、私密共享的数据 将使研究人员能够：(1)描述个体在 神经、认知、情绪和学习功能的术语及其影响因素；(2)发展国民 大脑健康发育的标准；(3)研究基因和环境的作用和相互作用 (4)检查体力活动、睡眠、屏幕时间、运动损伤(包括创伤性大脑) 伤害)和其他影响大脑发育的经历；(5)确定和复制影响 从童年到成年的心理健康；(6)表征心理健康和 物质使用；以及(7)具体说明大麻、酒精、烟草和咖啡因等物质的使用如何影响 发育结果，以及神经、认知、情绪和环境因素如何影响 青少年药物使用。