Visual Cortex as a Window to Microstructural and Functional Development of the Human Brain
Visual Cortex as a Window to Microstructural and Functional Development of the Human Brain
批准号:
10612974
负责人:
Kalanit Grill-Spector
金额:
$59.9万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-05-01 至 2026-04-30
关键词:
AgeAstrocytesBiologicalBiological MarkersBrainCategoriesCellsChildhoodClinicalCollaborationsContrast SensitivityCoupledCustomDataDevelopmentDiagnosisDiffusionDiffusion Magnetic Resonance ImagingFunctional Magnetic Resonance ImagingGene ExpressionGenerationsGenesGoalsHistologicHistologyHumanHuman DevelopmentImaging DeviceIndividualInfantInfant DevelopmentIronKnowledgeLifeLinkMeasurementMeasuresMethodologyMethodsMissionMolecularMultimodal ImagingMyelinNeuronsOligodendrogliaOutcomePathway interactionsPersonal SatisfactionProliferatingRelaxationResearchSamplingSignal PathwaySocietiesStructureSystems DevelopmentTemporal LobeTestingTissue SampleTissue-Specific Gene ExpressionTissuesVisionVisualVisual CortexVisual SystemVulnerable Populationsarea striatacell typeclinically significantcomputerized toolsextrastriate visual cortexgray matterimaging modalityimprovedin vivoinfancyinnovationinventionmultimodal neuroimagingmyelinationneuroimagingneuromechanismnovelopen sourceresponsetooltranscriptomicsvision developmentwhite matter
中文摘要
项目摘要
婴儿是一个高度脆弱的人群,对他们来说,诊断非典型与典型视觉皮质的能力
发展和及早干预是最重要的。然而,婴儿视觉皮质是如何发育的
除了初级视觉皮质(V1)外,在显微结构和功能上基本上是未知的。这项研究的目的是
是通过:(I)使用创新的定量(QMRI)、扩散(DMRI)和功能
(FMRI)磁共振成像,纵向测量并检查两者之间的关系
生命头两年期间人类视觉系统的显微结构和功能发育(目标1)。
(Ii)使用先进的组织学和定量方法在儿童视皮层样本中确定
微结构发育的生物学基础(目标2)。具体来说,Aim 1a将使用qMRI和dMRI
对0~24月龄婴儿视皮层的微结构发育进行纵向测量。我们会:(I)
测试不同视觉区域的发育是否不同,以及(Ii)检查微结构发育是否与
组织修剪或增殖。目标1b将使用dmri和qmri来纵向测量显微结构
0~24月龄婴儿视觉系统白质束发育及其关系探讨
白质和灰质发育之间的关系。Aim 1c将使用功能磁共振成像:(I)检查皮质发育
对视觉对比度的反应依赖于V1中的加工,而对视觉类别的反应依赖于
在腹侧颞叶皮质(VTC)的高级视觉区域进行处理,以及(Ii)确定是否起作用以及如何起作用
发育与同一婴儿的微结构发育有关。AIM 2将增强和验证
在0-24个月龄婴儿的组织样本中使用体外组织学进行活体测量。Aim 2a将使用定量组织学
目的:(I)测量V1和VTC皮质髓鞘形成的发展,以及(Ii)将组织学数据与体内的情况联系起来
用于确定哪些神经成像指标与髓鞘形成有关的指标。目标2b将:(1)量化
V1和VTC中多种细胞类型(所有细胞、神经元、星形胶质细胞和少突胶质细胞)的密度,以及(Ii)测试
如果发育随皮质的不同而不同,如果它与髓鞘形成有关。Aim 2c将使用转录切割技术
分析以确定基因表达途径并阐明与之相关的分子信号途径
V1和VTC的显微结构发育。拟议的研究具有很高的创新性和开创性,因为
它将首次提供体内和体外相结合的显微结构和功能测量
婴儿期人类视皮层的发育。这项研究很重要,因为它不仅将填补重大空白
在知识方面,还将开发新颖、尖端和开源的量化方法
与生物机制有关的皮质微结构的测量。因此,拟议的研究
具有广泛的社会和临床影响,因为它将导致诊断的非侵入性生物标志物的发展
婴儿的非典型视皮层发育,导致早期发明和更好的终生结果。
英文摘要
Project Summary
Babies are a highly vulnerable population for which the ability to diagnose atypical vs. typical visual cortex
development and intervene early could not be of greater importance. However, how infant visual cortex develops
microstructurally and functionally is largely unknown outside primary visual cortex (V1). The goal of this research
is to fill glaring gaps in knowledge by: (i) Using innovative quantitative (qMRI), diffusion (dMRI), and functional
(fMRI) magnetic resonance imaging, to longitudinally measure and examine the relationship between
microstructural and functional development of the human visual system during the first two years of life (Aim 1).
(ii) Using advanced histological and quantitative methods in pediatric samples of visual cortex, determine the
biological underpinnings of microstructural development (Aim 2). Specifically, Aim 1a will use qMRI and dMRI
to longitudinally measure the microstructural development of infant visual cortex from 0-24 months. We will: (i)
test if development varies across visual areas, and (ii) examine if microstructural development is associated with
tissue pruning or proliferation. Aim 1b will use dMRI and qMRI to longitudinally measure the microstructural
development of the white matter tracts of the infant visual system from 0-24 months and examine the relation
between white and gray matter development. Aim 1c will use fMRI to: (i) examine the development of cortical
responses to visual contrast, which rely on processing in V1, and responses to visual categories, which rely on
processing in high-level visual regions in ventral temporal cortex (VTC), and (ii) determine if and how functional
development is related to microstructural development in the same infants. Aim 2 will augment and validate in
vivo metrics using ex vivo histology in tissue samples of 0-24 months-olds. Aim 2a will use quantitative histology
to (i) measure the development of cortical myelination in V1 and VTC, and (ii) relate histological data to in vivo
metrics to determine which neuroimaging metrics are coupled with myelination. Aim 2b will: (i) quantify the
densities of multiple cell types (all cells, neurons, astrocytes, and oligodendrocytes) in V1 and VTC, and (ii) test
if development varies across cortical expanses and if it is tied to myelination. Aim 2c will use transcriptomic
analyses to determine gene expression pathways and elucidate molecular signaling pathways associated with
microstructural development in V1 and VTC. The proposed research is highly innovative and groundbreaking as
it will provide the first combined in vivo and ex vivo measurements of the microstructural and functional
development of human visual cortex in infancy. This research is important as it will not only fill significant gaps
in knowledge but also will develop novel, cutting-edge, and open-source methodologies for quantitative
measurements of cortical microstructure that are linked to biological mechanisms. Thus, the proposed research
has broad societal and clinical impact as it will lead to development of non-invasive biomarkers to diagnosis
atypical visual cortex development in infants, leading to early inventions and better life-long outcomes.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Neuroimaging and histological investigations of human visual cortex development
-
批准号:10017244
-
项目类别:
-
资助金额:$16.47万
-
财政年份:2019
-
负责人:Kalanit Grill-Spector
-
依托单位:
Neuroimaging and histological investigations of human visual cortex development
-
批准号:9806161
-
项目类别:
-
资助金额:$20.38万
-
财政年份:2019
-
负责人:Kalanit Grill-Spector
-
依托单位:
Functional-neuroanatomy of high-level visual cortex: a quantitative multimodal approach
-
批准号:10553230
-
项目类别:
-
资助金额:$39.05万
-
财政年份:2014
-
负责人:Kalanit Grill-Spector
-
依托单位:
Functional-neuroanatomy of High-level Visual Cortex: A Quantitative Multimodal Ap
-
批准号:8721703
-
项目类别:
-
资助金额:$38.18万
-
财政年份:2014
-
负责人:Kalanit Grill-Spector
-
依托单位:
Functional-neuroanatomy of high-level visual cortex: a quantitative multimodal approach
-
批准号:10357739
-
项目类别:
-
资助金额:$37.88万
-
财政年份:2014
-
负责人:Kalanit Grill-Spector
-
依托单位:
Functional-neuroanatomy of High-level Visual Cortex: A Quantitative Multimodal Ap
-
批准号:9306099
-
项目类别:
-
资助金额:$38.78万
-
财政年份:2014
-
负责人:Kalanit Grill-Spector
-
依托单位:
Functional-neuroanatomy of high-level visual cortex: a quantitative multimodal approach
-
批准号:10087937
-
项目类别:
-
资助金额:$37.91万
-
财政年份:2014
-
负责人:Kalanit Grill-Spector
-
依托单位:
Functional-neuroanatomy of High-level Visual Cortex: A Quantitative Multimodal Ap
-
批准号:8857322
-
项目类别:
-
资助金额:$38.01万
-
财政年份:2014
-
负责人:Kalanit Grill-Spector
-
依托单位:
Functional-neuroanatomy of high-level visual cortex: a quantitative multimodal approach
-
批准号:9883393
-
项目类别:
-
资助金额:$38.56万
-
财政年份:2014
-
负责人:Kalanit Grill-Spector
-
依托单位:
Functional-neuroanatomy of High-level Visual Cortex: A Quantitative Multimodal Ap
-
批准号:9511829
-
项目类别:
-
资助金额:$38.78万
-
财政年份:2014
-
负责人:Kalanit Grill-Spector
-
依托单位:
Development of Face Perception: Cross-sectional and Longitudinal Investigations
-
批准号:8400081
-
项目类别:
-
资助金额:$53.94万
-
财政年份:2012
-
负责人:Kalanit Grill-Spector
-
依托单位:
Development of Face Perception: Cross-sectional and Longitudinal Investigations
-
批准号:9447091
-
项目类别:
-
资助金额:$54.12万
-
财政年份:2012
-
负责人:Kalanit Grill-Spector
-
依托单位:
Development of Face Perception: Cross-sectional and Longitudinal Investigations
-
批准号:10376237
-
项目类别:
-
资助金额:$50.03万
-
财政年份:2012
-
负责人:Kalanit Grill-Spector
-
依托单位:
Development of Face Perception: Cross-sectional and Longitudinal Investigations
-
批准号:8532905
-
项目类别:
-
资助金额:$49.53万
-
财政年份:2012
-
负责人:Kalanit Grill-Spector
-
依托单位:
Development of Face Perception: Cross-sectional and Longitudinal Investigations
-
批准号:8725164
-
项目类别:
-
资助金额:$51.09万
-
财政年份:2012
-
负责人:Kalanit Grill-Spector
-
依托单位:
fMRI and Behavioral Studies of Unsupervised Learning in High Level Visual Cortex
-
批准号:8464120
-
项目类别:
-
资助金额:$36.12万
-
财政年份:2009
-
负责人:Kalanit Grill-Spector
-
依托单位:
fMRI and Behavioral Studies of Unsupervised Learning in High Level Visual Cortex
-
批准号:8068802
-
项目类别:
-
资助金额:$38.02万
-
财政年份:2009
-
负责人:Kalanit Grill-Spector
-
依托单位:
fMRI and Behavioral Studies of Unsupervised Learning in High Level Visual Cortex
-
批准号:7663500
-
项目类别:
-
资助金额:$40.0万
-
财政年份:2009
-
负责人:Kalanit Grill-Spector
-
依托单位:
fMRI and Behavioral Studies of Unsupervised Learning in High Level Visual Cortex
-
批准号:7802090
-
项目类别:
-
资助金额:$39.6万
-
财政年份:2009
-
负责人:Kalanit Grill-Spector
-
依托单位:
fMRI and Behavioral Studies of Unsupervised Learning in High Level Visual Cortex
-
批准号:8266462
-
项目类别:
-
资助金额:$38.02万
-
财政年份:2009
-
负责人:Kalanit Grill-Spector
-
依托单位:
国内基金
海外基金
Ascl1介导Wnt/beta-catenin通路在TLE海马硬化中反应性Astrocytes异常增生的作用及调控机制
-
批准号:31760279
-
项目类别:地区科学基金项目
-
资助金额:35.0万元
-
批准年份:2017
-
负责人:丁银秀
-
依托单位: