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Multimodal investigation of emotional reactivity as a predictor of later psychopathology in infants at risk for ASD

情绪反应作为自闭症谱系障碍婴儿后期精神病理学预测因子的多模式研究

基本信息

批准号：
10613533
负责人：
KATARZYNA CHAWARSKA
金额：
$ 73.79万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10613533
关键词：
Affective Age Months Aggressive behavior Anger Anxiety Area Arousal Attention Attenuated Behavioral Biological Markers Characteristics Clinical Data Development Diagnosis Diagnostic Disease Early Diagnosis Early Intervention Early identification Emotional Emotions Exhibits Face Family Feeling suicidal Foundations Fright Future General Population Genetic Goals Health Services Accessibility Hospitalization Impairment Impulsivity Infant Intervention Investigation Knowledge Life Link Measurement Measures Methods Modality Moods Nature Negative Valence Outcome Parents Pattern Phenotype Physiological Population Positive Valence Psychopathology Recommendation Reporting Research Research Domain Criteria Risk Risk Factors Severities Siblings Social Environment Standardization Statistical Models Stress Symptoms System TFF1 gene Temperament Toddler Vulnerable Populations autism spectrum disorder autistic children behavior measurement clinical care cohort comorbidity depressive symptoms disorder risk early childhood emotional reaction high risk high risk infant improved indexing individuals with autism spectrum disorder infancy innovation longitudinal design multimodality novel personalized diagnostics predictive marker preventive intervention prospective repetitive behavior response showing emotion social social deficits social vulnerability treatment services two-dimensional

项目摘要

SUMMARY Autism Spectrum Disorder (ASD) is characterized by social impairments and restricted and repetitive behaviors. Those with a genetic liability for social deficits, including individuals with ASD and their unaffected relatives are also at high risk for internalizing and externalizing conditions. The presence of comorbid affective and behavioral conditions impairs adaptive functioning, increases family stress, and is associated with psychiatric hospitalizations and residential placement. Identification of risk factors for internalizing and externalizing disorders amongst young children with ASD and their siblings would improve diagnostic practices and promote implementation of preventative and early interventions. Extensive research in the general population indicates that precursors of internalizing and externalizing disorders can be identified in the first two years of life as indexed by elevated or attenuated levels of Emotional Reactivity (eReactivity), or intensity of emotional reactions in response to internal or external triggers. Extant, albeit limited, evidence suggests that toddlers with ASD and their unaffected siblings exhibit atypical eReactivity profiles both on the behavioral and physiological levels, though the evidence is incomplete and both their origins and the links with later psychopathology are largely unknown. To fill this gap, we propose to prospectively examine the development of eReactivity from 4 to 30 months in 150 younger siblings of children with ASD, who, due to familial factors, are at high risk for developing ASD (HR) and 30 low-risk (LR) siblings. We plan to examine eReactivity to real- world triggers aimed to elicit fear, anger, and joy, and to evaluate the effects of the social and nonsocial nature of the triggers on eReactivity across the three emotions using a state-of-the-art multi-method behavioral and physiological approach. Aim 1 will evaluate prospectively whether the HRASD group (siblings with ASD), HRATP (siblings with developmental challenges), and HRTD (siblings without developmental challenges) are characterized by distinct patterns of eReactivity to social vs nonsocial triggers as measured by behavioral and physiological indices between 4 and 30 months compared to the LRTD group. The aim will clarify if differential emotional reactivity to social and nonsocial triggers constitutes an emerging characteristic of the autism phenotype in ASD. Aim 2 will examine predictive relationships between development of eReactivity in infancy and severity of internalizing and externalizing symptoms at 30 months. Identification of early predictors of internalizing/externalizing problems will facilitate access to early interventions aimed at amelioration of behavioral and emotional challenges. Consistent with the Research Domain Criteria research framework recommendations, the project (1) employs multiple levels of analysis, (2) investigates negative and positive valence systems as well as arousal systems, and (3) examines a spectrum of ASD risk with long-term goals of improving diagnostic precision in ASD and enabling discovery of novel treatment targets and interventions both during prodromal and early syndromal stages of the disorder.

总结