Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism
了解自闭症早期神经发育的细胞、分子和功能成像方法
基本信息
- 批准号:9560923
- 负责人:
- 金额:$ 240.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-07 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:12 year oldAddressAffectAgeAnatomyAttentionAutistic DisorderBehaviorBehavioralBiologicalBiological MarkersBiological ModelsBiological Neural NetworksBirthBrainBrain imagingCellsCharacteristicsChildChildhoodDataDevelopmentDiagnosisDiagnosticDiseaseEvaluationFemaleFetal DevelopmentFunctional ImagingFunctional Magnetic Resonance ImagingGeneticImageImpairmentInfantIntellectual functioning disabilityInterdisciplinary StudyInterventionInvestigationLearningLifeLinkMeasuresMethodologyMethodsMolecularNeonatalNeurobiologyNeurologyNeuronal PlasticityNeuronsNeurosciencesNewborn InfantOrganizational ChangeOrganoidsPatientsPatternPerinatalPhotonsPlayPregnancyPrognostic MarkerProspective cohortPsychopathologyRadiology SpecialtyReportingResearch Project GrantsResolutionRiskRisk FactorsRoleSchool-Age PopulationScientistSecond Pregnancy TrimesterSeveritiesSex CharacteristicsSiblingsSocial ValuesStem cellsSymptomsSynapsesSystemTestingThird Pregnancy TrimesterTimeToddlerTrainingbasebehavioral studycellular imagingcohortconnectomedensitydiagnostic biomarkerdisorder riskefficacy testingexecutive functionfetalhigh riskhuman modelimaging approachinduced pluripotent stem cellinfancyinhibitory neuroninnovationmalemolecular imagingmultidisciplinaryneonatal periodneural modelneurodevelopmentneuroimagingneuromechanismneurophysiologynovelnovel diagnosticsoutcome predictionpredicting responsepredictive modelingprenatalprognosticprogramsprotective factorsrecruitrelating to nervous systemresilienceresponserisk sharingsexstatistics
项目摘要
The Yale Center represents a multidisciplinary research program consisting of five inter-related research
projects and four cores dedicated to advancing understanding of early neurobiology of ASD. The proposal
brings together a team of experts from the fields of developmental psychopathology and neurobiology,
genetics, neurology, radiology, neuroscience, and statistics to identify the molecular, cellular, and neural
mechanisms related to ASD from prenatal stages to childhood. We focus our investigation on two cohorts of
younger siblings of children with ASD who, due to familial factors, are at high risk (HR) for developing the
disorder: a prospective cohort recruited pre- and perinatally and followed through 24 months, and a cohort of
HR siblings who was well-characterized at 24 months through our past studies and will reach the age of 12
years during the life of the Yale ACE. These cohorts enable our search for neural signatures of ASD during
fetal, neonatal, and school-age periods, as well as to examine the connectome across the spectrum of risk for
ASD both in males and females. Although neural and behavioral markers of ASD have been reported in 6-
month-old infants later diagnosed with ASD, to our best knowledge, this is the first investigation into both fetal
and neonatal functional connectivity in ASD. Emerging data suggest that male, but not female, ASD subjects
demonstrate significant alterations in neural networks, and – for the first time – the proposed studies will
identify not only the changes in connectivity in ASD but also the impact of fetal/neonatal sex upon these
changes. Since recent studies demonstrate neuroplasticity in the developing brain across the late second and
third trimesters of gestation, it is essential to understand if the factors associated with ASD are developing in
this same time frame and to understand any sex differences that may be apparent even at that early age. The
iPSC derived organoid system models human fetal development, allowing us to investigate neurobiological risk
and protective factors that play a unique role in this period and may enable the discovery of patient-specific
neuronal or stem cell biomarkers that could be used as predictors of risk or resilience in ASD. The Yale ACE
aims rely on application of cutting-edge approaches to the analysis the connectome, fetal and neonatal
imaging modeling neural development using the iPSC methodology with high resolution dual photon imaging
approaches, the development of early markers for ASD, studying early attention and learning, novel predictive
models relating brain organization to behavior, and statistical approaches for integrating the spectrum of data
types across to address these aims. Results from the combined projects have a great potential to identify novel
diagnostic and prognostic markers at the time of birth, identify neural, cellular, and molecular bases of risk and
protective mechanisms in ASD, and clarify neural bases of sex differences in ASD.
耶鲁中心代表了一个多学科研究项目,由五个相互关联的研究组成
项目成果
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KATARZYNA CHAWARSKA其他文献
KATARZYNA CHAWARSKA的其他文献
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{{ truncateString('KATARZYNA CHAWARSKA', 18)}}的其他基金
Multimodal investigation of emotional reactivity as a predictor of later psychopathology in infants at risk for ASD
情绪反应作为自闭症谱系障碍婴儿后期精神病理学预测因子的多模式研究
- 批准号:
10296223 - 财政年份:2021
- 资助金额:
$ 240.55万 - 项目类别:
Multimodal investigation of emotional reactivity as a predictor of later psychopathology in infants at risk for ASD
情绪反应作为自闭症谱系障碍婴儿后期精神病理学预测因子的多模式研究
- 批准号:
10613533 - 财政年份:2021
- 资助金额:
$ 240.55万 - 项目类别:
Multimodal investigation of emotional reactivity as a predictor of later psychopathology in infants at risk for ASD
情绪反应作为自闭症谱系障碍婴儿后期精神病理学预测因子的多模式研究
- 批准号:
10430237 - 财政年份:2021
- 资助金额:
$ 240.55万 - 项目类别:
Attentional, temperamental, and physiological process underlying anxiety in preschoolers with ASD
患有自闭症谱系障碍 (ASD) 的学龄前儿童焦虑的注意力、气质和生理过程
- 批准号:
9217354 - 财政年份:2017
- 资助金额:
$ 240.55万 - 项目类别:
Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism
了解自闭症早期神经发育的细胞、分子和功能成像方法
- 批准号:
10240556 - 财政年份:2017
- 资助金额:
$ 240.55万 - 项目类别:
Neonatal connectome as a predictor of social and attentional impairment in ASD
新生儿连接组作为 ASD 社交和注意力障碍的预测因子
- 批准号:
10240559 - 财政年份:2017
- 资助金额:
$ 240.55万 - 项目类别:
Preliminary efficacy of social reward value training in toddlers with elevated symptoms of autism
社会奖励价值训练对自闭症症状加重的幼儿的初步效果
- 批准号:
10240563 - 财政年份:2017
- 资助金额:
$ 240.55万 - 项目类别:
Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism
了解自闭症早期神经发育的细胞、分子和功能成像方法
- 批准号:
9767864 - 财政年份:2017
- 资助金额:
$ 240.55万 - 项目类别:
A Multimedia Screening System for Early ASD Identification in Diverse Populations
用于不同人群早期 ASD 识别的多媒体筛查系统
- 批准号:
8893574 - 财政年份:2015
- 资助金额:
$ 240.55万 - 项目类别:
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