Neonatal connectome as a predictor of social and attentional impairment in ASD
新生儿连接组作为 ASD 社交和注意力障碍的预测因子
基本信息
- 批准号:10240559
- 负责人:
- 金额:$ 24.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-07 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAffective SymptomsAgeAttentionBirthBrainCategoriesChildClinicCognitiveDiagnosisDiagnosticDimensionsDiseaseEnvironmentExhibitsFaceFemaleFoundationsFunctional ImagingGroupingImpairmentIndividual DifferencesInfantMagnetic Resonance ImagingMonitorNeonatalNewborn InfantNewly DiagnosedOutcomePatternPerformancePlayPropertyRecording of previous eventsRestRiskRoleSchool-Age PopulationScienceSeveritiesSex DifferencesSiblingsSocial DevelopmentSocial FunctioningSymptomsToddlerautism spectrum disorderautistic childrenbasecellular imagingcognitive developmentconnectomeexecutive functionexperiencehigh riskimaging approachmolecular imagingneonateneurodevelopmentpsychologicreduce symptomsrelating to nervous systemsex risksocialsocial attentionvisual tracking
项目摘要
Limited attention to faces of conspecifics constitutes one of the markers of ASD.1-4 Limited attention to faces is
associated with increased severity of autism symptoms and poor adaptive functioning,5-8 and early individual
differences in attention to faces contribute to the variability in later social and cognitive outcomes.5 Attention to
faces is enhanced in 6-month-old unaffected females at familial risk for ASD and predicts better social
functioning 1.5 years later.9 Despite the well-documented role that monitoring faces of conspecifics plays in
socio-cognitive development, the brain mechanisms underlying such deficits in ASD are unknown and
treatments typically focus on ameliorating symptoms rather than addressing underlying causes. Considering
that signs of atypical attention to faces are evident by 6 to 9 months in infants later diagnosed with ASD both in
laboratory1-3, 10 and real-world environments, 11-13, [Preliminary Study (PS#1)], we hypothesize that the neural
foundations for these impairments are already reflected in functional brain organization (the connectome) at
birth. Attentional functions in the brain are subserved by the Salience Network (SN), the Executive Control
Network (ECN), and the Default Mode Network (DMN), all of which have been implicated in ASD,14-16 and have
been found to be atypical in newborns at risk for ASD due to non-familial factors (PS#2). Here we propose to
examine whether, when compared to unaffected high-risk (HR) and low-risk (LR) newborns, HR newborns
who, at 24 months, meet criteria for ASD exhibit abnormal strength of functional connectivity within the three
networks. We will also examine whether the strength of functional connectivity in the three networks at birth is
predictive of later performance on a selective social attention (SSA) eye-tracking task at 6 and 24 months and
severity of autism symptoms at 24 months. By targeting neonates, we plan to investigate properties of
attentional networks known to be affected in ASD14-16 before they are shaped extensively by extra-uterine
experience. To achieve these aims, we propose to study 120 neonates who have an older sibling with ASD
(HR) and 30 neonates without familial history of ASD (LR). The neonates will undergo a resting-state functional
connectivity MRI (rs fcMRI) at 42-44 post-menstrual weeks and at 6 and 24 months will be administered the
SSA task. Performance on this task discriminates between ASD and non-ASD groups during prodromal stages
of the disorder in high-risk siblings of children with ASD,1 in clinic-referred toddlers newly diagnosed with
ASD,17 and in school-age children (PS#3) and shows strong associations with autism symptom severity5
(PS#3). Diagnostic assessment will be completed at 24 months through which severity of autism symptoms
and diagnostic grouping will be determined. The project advances integration of psychological and brain
science in autism by investigating whether functional brain organization in ASD is altered at birth and, if so,
how this disruption affects social development in infants at risk for ASD.
对同种面孔的注意有限是自闭症的标志之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KATARZYNA CHAWARSKA其他文献
KATARZYNA CHAWARSKA的其他文献
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{{ truncateString('KATARZYNA CHAWARSKA', 18)}}的其他基金
Multimodal investigation of emotional reactivity as a predictor of later psychopathology in infants at risk for ASD
情绪反应作为自闭症谱系障碍婴儿后期精神病理学预测因子的多模式研究
- 批准号:
10296223 - 财政年份:2021
- 资助金额:
$ 24.36万 - 项目类别:
Multimodal investigation of emotional reactivity as a predictor of later psychopathology in infants at risk for ASD
情绪反应作为自闭症谱系障碍婴儿后期精神病理学预测因子的多模式研究
- 批准号:
10613533 - 财政年份:2021
- 资助金额:
$ 24.36万 - 项目类别:
Multimodal investigation of emotional reactivity as a predictor of later psychopathology in infants at risk for ASD
情绪反应作为自闭症谱系障碍婴儿后期精神病理学预测因子的多模式研究
- 批准号:
10430237 - 财政年份:2021
- 资助金额:
$ 24.36万 - 项目类别:
Attentional, temperamental, and physiological process underlying anxiety in preschoolers with ASD
患有自闭症谱系障碍 (ASD) 的学龄前儿童焦虑的注意力、气质和生理过程
- 批准号:
9217354 - 财政年份:2017
- 资助金额:
$ 24.36万 - 项目类别:
Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism
了解自闭症早期神经发育的细胞、分子和功能成像方法
- 批准号:
10240556 - 财政年份:2017
- 资助金额:
$ 24.36万 - 项目类别:
Preliminary efficacy of social reward value training in toddlers with elevated symptoms of autism
社会奖励价值训练对自闭症症状加重的幼儿的初步效果
- 批准号:
10240563 - 财政年份:2017
- 资助金额:
$ 24.36万 - 项目类别:
Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism
了解自闭症早期神经发育的细胞、分子和功能成像方法
- 批准号:
9560923 - 财政年份:2017
- 资助金额:
$ 24.36万 - 项目类别:
Cellular, molecular, and functional imaging approaches to understanding early neurodevelopment in autism
了解自闭症早期神经发育的细胞、分子和功能成像方法
- 批准号:
9767864 - 财政年份:2017
- 资助金额:
$ 24.36万 - 项目类别:
A Multimedia Screening System for Early ASD Identification in Diverse Populations
用于不同人群早期 ASD 识别的多媒体筛查系统
- 批准号:
8893574 - 财政年份:2015
- 资助金额:
$ 24.36万 - 项目类别:
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