Novel 'Mechano-medicine' combats deadly sticky blood clots in diabetes

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This project aims to elucidate a novel biomechanical mechanism that associates with mechanical force generated by dynamic blood flow and leads to enhanced blood clotting in diabetes. The outcome may likely explain the reduced efficacy of current anti-clotting drugs (i.e. Aspirin, Plavix® or Brilinta®) in individuals with diabetes, which does not take the 'force effect' into account. Moreover, it will provide an innovative therapeutic strategy to reduce the sticky blood clots of diabetes.