Novel 'Mechano-medicine' combats deadly sticky blood clots in diabetes

新型“机械医学”可对抗糖尿病中致命的粘性血栓

• 批准号: nhmrc : 2003904
• 金额: $ 76.07万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-mechano-medicine-clots-diabetes/1780242
• 关键词: Novel; Mechano; medicine; combats; deadly

This project aims to elucidate a novel biomechanical mechanism that associates with mechanical force generated by dynamic blood flow and leads to enhanced blood clotting in diabetes. The outcome may likely explain the reduced efficacy of current anti-clotting drugs (i.e. Aspirin, Plavix® or Brilinta®) in individuals with diabetes, which does not take the 'force effect' into account. Moreover, it will provide an innovative therapeutic strategy to reduce the sticky blood clots of diabetes.

该项目旨在阐明一种新型生物力学机制，该机制与动态血流产生的机械力相关，并导致糖尿病患者血液凝固增强。这一结果可能解释了目前的抗凝药物（即阿司匹林、Plaetin ®或Brilinta®）在糖尿病患者中疗效降低的原因，因为这些药物没有考虑到“力效应”。此外，它将提供一种创新的治疗策略，以减少糖尿病的粘性血凝块。