Component for Institution # 19-01414

机构组件

• 批准号: 10612843
• 负责人: Matthew Jorgensen
• 金额: $ 72.38万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612843
• 关键词: Address; African Green Monkey; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease risk; Animals; Applied Research; Area; Autopsy; Behavioral; Biological; Biological Markers; Biomedical Research; Biopsy; Blood Chemical Analysis; Caribbean region; Cercopithecus tantalus; Cerebrospinal Fluid; Clinical Sciences; Clinical and Translational Science Awards; Communicable Diseases; Communities; Consultations; Data; Dengue Fever; Development; Diabetes Mellitus; Discipline; Ensure; Etiology; Evaluation; Fatty acid glycerol esters; Fostering; Funding; Genetic; Genome; Genomics; Genotype; Health; Influenza; Infrastructure; Institution; Investigation; Lipids; Longevity; Measurement; Medicine; Metabolic; Metabolic Diseases; Methodology; Mothers; Multimodal Imaging; Muscle; Neonatal; Neurodegenerative Disorders; Obesity; Pathology; Phenotype; Physiological; Plasma; Play; Population; Primates; Research; Research Personnel; Resources; Respiratory syncytial virus; Role; Sampling; Serum; Services; Site; Source; Study models; Synapses; System; Technical Expertise; Tissues; Training; Translational Research; United States National Institutes of Health; Vaccines; Veterinarians; Viral; animal resource; biomedical imaging; biomedical resource; cardiometabolism; career; clinical care; clinical phenotype; comparative; data repository; forest; gene therapy; genetic pedigree; genetic resource; human disease; human model; image translation; imaging capabilities; imaging program; interest; medical schools; meetings; nonhuman primate; novel; outreach; pathogen; phenotypic data; precision medicine; programs; psychosocial development; repository; reproductive; research facility; screening; social group; training opportunity; translational model; translational potential; translational study; vervet; β-amyloid burden

This application is a competing renewal of the "Vervet Research Colony as a Biomedical Resource" (VRC, P40-OD010965). The VRC is the only NIH-funded biomedical research resource for US-born vervet/African green monkeys (AGM; Chlorocebus aethiops sabaeus) and has been continuously funded since 2005. The VRC serves a wide range of local, regional and national investigators by providing animals, biological samples, data, consultation and training pertaining to the use of vervets/AGMs as multi-categorical, translational models of human disease. Since the previous renewal, the VRC has provided resources to over 100 investigators, including over 250 animals and over 1,500 biological samples, as well as data and consultation. The VRC has also provided the necessary infrastructure and technical expertise enabling the on-site use of over 600 animals across 30 different studies. The VRC has facilitated critical translational research across a wide variety of disciplines, including: a) the development of the vervet as an emerging nonhuman primate model of Alzheimer's disease risk with a focus on the assessment of amyloid burden, neurodegenerative disease biomarkers, and synaptic degeneration; b) investigations into the efficacy and enhancement of vaccines for infectious diseases such as neonatal influenza, respiratory syncytial virus, and dengue fever; c) studies focused on the etiology and health consequences of diabetes, metabolic disease and obesity; d) the development of novel, non-invasive biomedical imaging methodologies; and e) the expansion of the critical genetic resources available for vervets, including the sequencing of the vervet genome. The aims of the VRC resource are to: 1) provide the scientific community with access to animals, biological samples, data and expertise to facilitate the use of vervets for a wide-range of biomedical research; 2) to provide exceptional training opportunities for veterinarians and researchers interested in using vervets for translational research, and to serve as a platform for community and scientific outreach to foster better understanding of the use of nonhuman primates in biomedical research; and 3) to enhance the resource by engaging in applied research focused on continuing genetic and phenotypic characterization of vervets across the lifespan and evaluation of the vervet as a potential translational model in novel research areas. The VRC is a critical component of the Wake Forest Clinical and Translational Science Award (CTSA), which provides administrative support and facilitates the utilization of the VRC resource across the larger CTSA network. The VRC is able to take full advantage of a wide-range of existing research facilities within the Wake Forest School of Medicine, including multi-modal imaging capabilities, veterinary and pathology expertise, and genetic and analytic resources.

该应用程序是“作为生物医学资源的Vervet研究群”的竞争性更新。