The Vervet Research Colony as Biomedical Resource

作为生物医学资源的黑长尾黑长尾猴研究群体

• 批准号: 10806701
• 负责人: Matthew Jorgensen
• 金额: $ 21.76万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10806701
• 关键词: Acoustic Stimulation; Administrative Supplement; African Green Monkey; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease risk; Animal Behavior; Animal Experimentation; Animal Housing; Animal Welfare; Animals; Applied Research; Area; Behavior; Biocompatible Materials; Biological; Biomedical Research; COVID-19; COVID-19 pandemic; Caribbean region; Caring; Cercopithecus tantalus; Clinical; Clinical Treatment; Cognitive; Communicable Diseases; Communities; Complex; Consultations; Data; Dedications; Dengue Fever; Development; Diabetes Mellitus; Discipline; Environment; Etiology; Fostering; Funding; Generations; Genetic; Genotype; Health; Housing; Immunology; Influenza; Injections; Insulin; Investigation; Longevity; Metabolic Diseases; Monitor; Neonatal; Neuropsychology; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Observational Study; Phenotype; Photic Stimulation; Physical activity; Play; Population; Procedures; Research; Research Personnel; Research Project Grants; Research Subjects; Resources; Respiratory syncytial virus; Role; Sampling; Science; Sensory; Source; Study Subject; System; Tablets; Television; Testing; Training; Translational Research; United States National Institutes of Health; Vaccines; Veterinarians; Well in self; animal care; biomedical imaging; biomedical resource; cognitive task; cohort; design; environmental enrichment for laboratory animals; human disease; human model; improved; innovation; interest; metabolic abnormality assessment; nonhuman primate; novel; outreach; parent grant; psychosocial; social; social group; training opportunity; translational model; vaccine development; vervet

PROJECT SUMMARY This application is an administrative supplement to the "Vervet Research Colony as a Biomedical Resource" (VRC, P40-OD010965). The purpose of this application is to obtain funds to support alterations and renovations (A&R) to enhance the indoor animal housing space used by this unique nonhuman primate resource. The VRC is the only NIH-funded biomedical research resource for US-born vervet/African green monkeys (AGM; Chlorocebus aethiops sabaeus) and has been continuously funded since 2005. As an Animal and Biological Material Resource (ABMR), the VRC serves a wide range of local, regional and national investigators by providing animals, biological samples, data, consultation and training pertaining to the use of vervets/AGMs as multi-categorical, translational models of human disease. The VRC has facilitated critical translational research across a wide variety of disciplines, including: aging and Alzheimer's disease; immunology and vaccine development; diabetes, metabolic disease and obesity; biomedical imaging; and genetics, among others. The aims of the parent grant are to: 1) provide the scientific community with access to animals, biological samples, data and expertise to facilitate the use of vervets for a wide-range of biomedical research; 2) to provide exceptional training opportunities, and to serve as a platform for community and scientific outreach; and 3) to enhance the resource by engaging in applied research focused on continuing genetic and phenotypic characterization and expanding potential of the vervet as a translational model in novel research areas. For this A&R supplement, we propose to design, build and install novel enrichment cages that improve the physical and psychosocial environment for a subset of the animal population that can't be housed in species typical social groups due to clinical or experimental reasons. We also propose to install infrared cameras to add this new housing area to our existing 24h surveillance camera system; and to improve sensory and cognitive enrichment. These efforts will enhance animal welfare and veterinary care, while also opening up new research opportunities.

项目概要 本申请是“黑长尾黑长尾猴研究群作为生物医学资源”的行政补充 （VRC，P40-OD010965）。此申请的目的是获得资金以支持变更和 翻新 (A&R)，以改善这种独特的非人类灵长类动物所使用的室内动物饲养空间 资源。 VRC 是美国国立卫生研究院 (NIH) 资助的唯一针对美国出生的长尾黑颚猴/非洲绿长尾猴的生物医学研究资源 猴子（AGM；Chlorocebus aethiops sabaeus），自 2005 年以来一直得到持续资助。作为一种动物 和生物材料资源 (ABMR)，VRC 为广泛的地方、区域和国家服务 研究人员通过提供动物、生物样本、数据、咨询和有关使用的培训 Vervets/AGM 作为人类疾病的多类别转化模型。 VRC 促进了关键 跨多个学科的转化研究，包括：衰老和阿尔茨海默病； 免疫学和疫苗开发；糖尿病、代谢性疾病和肥胖；生物医学成像；和 遗传学等。家长资助的目的是： 1) 为科学界提供获得 动物、生物样本、数据和专业知识，以促进黑长尾猴在广泛的生物医学领域的使用 研究; 2）提供卓越的培训机会，并为社区和社区提供平台 科学推广； 3）通过从事专注于持续发展的应用研究来增强资源 长尾黑颚猴的遗传和表型特征以及作为小说中转化模型的扩展潜力 研究领域。对于本 A&R 补充，我们建议设计、建造和安装新颖的浓缩笼， 改善无法安置的一部分动物的身心环境 由于临床或实验原因，在物种中具有典型的社会群体。我们还建议安装红外线 摄像头将这个新的住宅区添加到我们现有的 24 小时监控摄像系统中；并改善感官 和认知丰富。这些努力将加强动物福利和兽医护理，同时也开放 新的研究机会。