The Vervet Research Colony as Biomedical Resource

项目总结 本申请是对“作为生物医学资源的韦尔韦特研究群体”的行政补充 (VRC，P40-OD010965)。本申请的目的是获得资金以支持改建和 翻新(A&R)以增强这种独特的非人类灵长类动物使用的室内动物住所空间 资源。VRC是美国出生的马鞭草/非洲绿的唯一由NIH资助的生物医学研究资源 自2005年以来，该基金一直得到持续资助。作为一种动物 和生物材料资源(ABMR)，VRC服务于广泛的地方、地区和国家 通过提供动物、生物样本、数据、咨询和与使用 Vervets/AGMS作为人类疾病的多分类、翻译模型。VRC促进了关键的 跨多个学科的翻译研究，包括：衰老和阿尔茨海默病； 免疫学和疫苗开发；糖尿病、代谢性疾病和肥胖；生物医学成像；以及 遗传学，还有其他的。家长资助的目的是：1)为科学界提供 动物、生物样本、数据和专业知识，以促进将马鞭草用于广泛的生物医学 研究；2)提供特殊的培训机会，并作为社区和 科学宣传；以及3)通过从事侧重于继续的应用研究来加强资源 小说中动词作为翻译模式的遗传和表型特征及其扩展潜力 研究领域。对于这一A&R补充，我们建议设计、建造和安装新的增肥笼，以 为部分无法安置的动物群体改善物质和心理社会环境 在物种中，由于临床或实验原因，典型的社会群体。我们还建议安装红外线 摄像头将这个新的住宅区添加到我们现有的24小时监控摄像头系统中；并改善感官 和认知能力的丰富。这些努力将加强动物福利和兽医护理，同时也开放 新的研究机会。

PROJECT SUMMARY This application is an administrative supplement to the "Vervet Research Colony as a Biomedical Resource" (VRC, P40-OD010965). The purpose of this application is to obtain funds to support alterations and renovations (A&R) to enhance the indoor animal housing space used by this unique nonhuman primate resource. The VRC is the only NIH-funded biomedical research resource for US-born vervet/African green monkeys (AGM; Chlorocebus aethiops sabaeus) and has been continuously funded since 2005. As an Animal and Biological Material Resource (ABMR), the VRC serves a wide range of local, regional and national investigators by providing animals, biological samples, data, consultation and training pertaining to the use of vervets/AGMs as multi-categorical, translational models of human disease. The VRC has facilitated critical translational research across a wide variety of disciplines, including: aging and Alzheimer's disease; immunology and vaccine development; diabetes, metabolic disease and obesity; biomedical imaging; and genetics, among others. The aims of the parent grant are to: 1) provide the scientific community with access to animals, biological samples, data and expertise to facilitate the use of vervets for a wide-range of biomedical research; 2) to provide exceptional training opportunities, and to serve as a platform for community and scientific outreach; and 3) to enhance the resource by engaging in applied research focused on continuing genetic and phenotypic characterization and expanding potential of the vervet as a translational model in novel research areas. For this A&R supplement, we propose to design, build and install novel enrichment cages that improve the physical and psychosocial environment for a subset of the animal population that can't be housed in species typical social groups due to clinical or experimental reasons. We also propose to install infrared cameras to add this new housing area to our existing 24h surveillance camera system; and to improve sensory and cognitive enrichment. These efforts will enhance animal welfare and veterinary care, while also opening up new research opportunities.