Vervet Research Colony as a Biomedical Resource

作为生物医学资源的黑长尾黑长尾猴研究群体

• 批准号: 10612842
• 负责人: Matthew Jorgensen
• 金额: $ 72.38万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612842
• 关键词: Address; African Green Monkey; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease risk; Animals; Applied Research; Area; Autopsy; Behavioral; Biological; Biological Markers; Biomedical Research; Biopsy; Blood Chemical Analysis; Cardiometabolic Disease; Caribbean region; Cercopithecus tantalus; Cerebrospinal Fluid; Clinical and Translational Science Awards; Communicable Diseases; Communities; Consultations; Data; Dedications; Dengue Fever; Development; Diabetes Mellitus; Discipline; Ensure; Etiology; Evaluation; Fatty acid glycerol esters; Fostering; Funding; Genetic; Genome; Genomics; Genotype; Health; Influenza; Infrastructure; Investigation; Lipids; Longevity; Maintenance; Measurement; Medicine; Metabolic; Metabolic Diseases; Methodology; Mothers; Multimodal Imaging; Muscle; Neonatal; Neurodegenerative Disorders; Neurosciences; Obesity; Pathology; Phenotype; Physiological; Plasma; Play; Population; Primates; Research; Research Personnel; Resources; Respiratory syncytial virus; Role; Sampling; Serum; Services; Site; Source; Study models; Synapses; System; Technical Expertise; Tissues; Training; Translational Research; United States National Institutes of Health; Vaccines; Veterinarians; Viral; animal resource; biomedical imaging; biomedical resource; cardiometabolism; career; clinical care; clinical phenotype; comparative; data archive; data repository; forest; gene therapy; genetic pedigree; genetic resource; human disease; human model; image translation; imaging capabilities; imaging program; interest; medical schools; meetings; nonhuman primate; novel; outreach; pathogen; phenotypic data; precision medicine; programs; psychosocial development; repository; reproductive; research facility; screening; social group; training opportunity; translational model; translational potential; translational study; vaccine development; vervet; β-amyloid burden

This application is a competing renewal of the "Vervet Research Colony as a Biomedical Resource" (VRC, P40-OD010965). The VRC is the only NIH-funded biomedical research resource for US-born vervet/African green monkeys (AGM; Chlorocebus aethiops sabaeus) and has been continuously funded since 2005. The VRC serves a wide range of local, regional and national investigators by providing animals, biological samples, data, consultation and training pertaining to the use of vervets/AGMs as multi-categorical, translational models of human disease. Since the previous renewal, the VRC has provided resources to over 100 investigators, including over 250 animals and over 1,500 biological samples, as well as data and consultation. The VRC has also provided the necessary infrastructure and technical expertise enabling the on-site use of over 600 animals across 30 different studies. The VRC has facilitated critical translational research across a wide variety of disciplines, including: a) the development of the vervet as an emerging nonhuman primate model of Alzheimer's disease risk with a focus on the assessment of amyloid burden, neurodegenerative disease biomarkers, and synaptic degeneration; b) investigations into the efficacy and enhancement of vaccines for infectious diseases such as neonatal influenza, respiratory syncytial virus, and dengue fever; c) studies focused on the etiology and health consequences of diabetes, metabolic disease and obesity; d) the development of novel, non-invasive biomedical imaging methodologies; and e) the expansion of the critical genetic resources available for vervets, including the sequencing of the vervet genome. The aims of the VRC resource are to: 1) provide the scientific community with access to animals, biological samples, data and expertise to facilitate the use of vervets for a wide-range of biomedical research; 2) to provide exceptional training opportunities for veterinarians and researchers interested in using vervets for translational research, and to serve as a platform for community and scientific outreach to foster better understanding of the use of nonhuman primates in biomedical research; and 3) to enhance the resource by engaging in applied research focused on continuing genetic and phenotypic characterization of vervets across the lifespan and evaluation of the vervet as a potential translational model in novel research areas. The VRC is a critical component of the Wake Forest Clinical and Translational Science Award (CTSA), which provides administrative support and facilitates the utilization of the VRC resource across the larger CTSA network. The VRC is able to take full advantage of a wide-range of existing research facilities within the Wake Forest School of Medicine, including multi-modal imaging capabilities, veterinary and pathology expertise, and genetic and analytic resources.

这项申请是“作为生物医学资源的韦尔韦特研究群体”的竞争性更新 (VRC，P40-OD010965)。VRC是美国出生的NIH资助的唯一生物医学研究资源 Verveet/非洲绿猴(AGM；ChlorOcean bus atheiopsSabaeus)，并一直得到资助 自2005年以来。VRC为广泛的地方、区域和国家调查人员提供服务 与使用马鞭草/动植物有关的动物、生物样本、数据、咨询和培训 作为人类疾病的多范畴翻译模型。自上次续期以来，VRC 已经为100多名调查人员提供了资源，包括250多只动物和1500多只 生物样本，以及数据和咨询。VRC还提供了必要的 基础设施和技术专长使30个国家的600多只动物能够在现场使用 不同的研究。VRC促进了广泛范围内的批判性翻译研究 学科，包括：a)将鞭毛虫发展为一种新兴的非人类灵长类动物模型 阿尔茨海默病风险，重点评估淀粉样蛋白负荷、神经退行性变 疾病生物标志物和突触变性；b)疗效和增强的研究 针对新生儿流感、呼吸道合胞病毒等传染病的疫苗，以及 登革热；c)研究重点是糖尿病、代谢疾病的病因和健康后果 疾病和肥胖；d)开发新的非侵入性生物医学成像方法； 和e)扩大可供牡蛎使用的关键遗传资源，包括 马鞭草基因组的测序。VRC资源的目的是：1)提供科学的 社区能够获得动物、生物样本、数据和专门知识，以便利使用 用于广泛的生物医学研究的Vervets；2)提供特殊的培训机会 对于有兴趣使用马鞭草进行翻译研究的兽医和研究人员，以及 作为社区和科学宣传的平台，促进对该用途的更好理解 非人灵长类在生物医学研究中的应用；3)通过从事应用来增强资源 研究的重点是持续的遗传和表型特征，在世界各地 在新的研究领域中作为潜在的翻译模型的寿命和评价。 VRC是维克森林临床和翻译科学奖(CTSA)的重要组成部分， 它提供管理支持并促进VRC资源的利用 更大的CTSA网络。VRC能够充分利用现有的广泛的 维克森林医学院内的研究设施，包括多模式成像 能力、兽医和病理学专业知识以及遗传和分析资源。