Next Generation Temporal Interference Stimulation for Non-Invasive Neuromodulation
用于非侵入性神经调节的下一代时间干扰刺激
基本信息
- 批准号:10615485
- 负责人:
- 金额:$ 24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-01 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:Animal ExperimentsAnimalsBrainBrain regionCalibrationCellsCephalicChargeClinicalConsumptionDeep Brain StimulationDementiaDiseaseElectric StimulationElectrodesEpilepsyEvaluationFOS geneFrequenciesHealthHemorrhageHigh Frequency OscillationHumanImplanted ElectrodesIn VitroIndividualInfectionInflammationIon ChannelKnowledgeLeadLinkLocationMedicalMembraneMembrane PotentialsMental DepressionMethodsModelingMovement DisordersMuscleNerveNerve FibersNeuronsOpticsParkinson DiseasePenetrationPeriodicalsPeripheral Nervous SystemPhasePhysiologicalPropertyProtocols documentationRampReportingResearchResolutionRiskSignal TransductionSiteSpeedStimulusStrokeSurfaceTechnologyTestingTissuesTranslatingaddictionattenuationchronic painclinical applicationdesigndisease diagnosisdisease diagnosticelectric fieldexperimental studyimprovedin silicoin vivointerestneuralneuronal circuitryneuroregulationneurosurgeryneurotransmissionnext generationnovelperipheral painpredictive modelingpreventsimulationtool
项目摘要
Electrostimulation (ES) is a versatile and efficient tool for interrogating, altering, and manipulating neural
activities in health and disease. Deep brain ES delivered with implanted electrodes requires an elaborate
neurosurgery and carries risks of tissue damage, bleeding, stroke, infection, and inflammation. This limits the
use of deep brain ES for disease diagnostics and conditions that may not justify the risks.
Non-invasive targeted deep brain ES has long been a major quest, with countless potential applications.
The challenge is avoiding stimulation near surface electrodes, where the electric field is the strongest, while
stimulating at a depth by a (much) weaker electric field. One way to stimulate at a distance is by temporal
interference (TI) of two high-frequency sine waves delivered with a small frequency shift. The interference of
two such waves creates an amplitude-modulated stimulus at the target. Assumed demodulation of this signal
by neurons leads to their excitation at the modulation frequency.
Here, we introduce an entirely different concept of the temporal interference, based on (a) complete
cancellation of identical frequency carrier signals at the target, and (b) on the introduction of transient
distortions in one or both these signals. The distortions, such as a brief frequency or phase shift, will be
concealed by the strong periodic signal near the stimulating electrodes and will not lead to excitation at the
surface. However, these distortions will add up at the remote target location. They will stand out from the
“silent” background and will readily lead to excitation despite the attenuation of the electric field with distance.
We will perform mechanistic studies which support this next generation TI (NG-TI) stimulation paradigm. We
will continue with the design and experimental evaluation of different NG-TI protocols in vitro, in comparison
with the “standard” TI. We will systematically analyze the impact of TI stimulation parameters, to achieve
targeted tuning and modulation of individual neurons and neuronal circuitry. We hypothesize that NG-TI can be
improved for more focal stimulation, with much better penetration. It will have lower electric charge stimulation
threshold and enable better steerability than the standard TI. The most efficient NG-TI protocols will further be
validated by in vivo animal experiments. We will qualitatively compare targeting, possible off-site effects,
current consumption, and steerability of NG-TI and the standard TI. We will also define the feasibility and
model the electric field parameters for NG-TI stimulation at distances useful for medical applications. The
effects will be linked to dielectric and physiological properties of neurons and neural tissue, to build predictive
models for non-invasive deep brain stimulation in large animal and human trials. This project will lay the ground
to translate the NG-TI technology for disease diagnosis and treatment.
电刺激(ES)是一种多功能和有效的工具,用于询问,改变和操纵神经系统
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Andrei G Pakhomov其他文献
Andrei G Pakhomov的其他文献
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{{ truncateString('Andrei G Pakhomov', 18)}}的其他基金
Targeted Neuromodulation by Nanosecond Pulsed Electric Fields
纳秒脉冲电场的靶向神经调节
- 批准号:
10669767 - 财政年份:2022
- 资助金额:
$ 24万 - 项目类别:
Targeted Neuromodulation by Nanosecond Pulsed Electric Fields
纳秒脉冲电场的靶向神经调节
- 批准号:
10515459 - 财政年份:2022
- 资助金额:
$ 24万 - 项目类别:
Low Energy Defibrillation with Nanosecond Pulsed Electric Field
纳秒脉冲电场低能量除颤
- 批准号:
8941895 - 财政年份:2015
- 资助金额:
$ 24万 - 项目类别:
Low Energy Defibrillation with Nanosecond Pulsed Electric Field
纳秒脉冲电场低能量除颤
- 批准号:
9278268 - 财政年份:2015
- 资助金额:
$ 24万 - 项目类别:
Picosecond pulse technology for non-invasive electrostimulation
用于无创电刺激的皮秒脉冲技术
- 批准号:
8811947 - 财政年份:2014
- 资助金额:
$ 24万 - 项目类别:
Picosecond pulse technology for non-invasive electrostimulation
用于无创电刺激的皮秒脉冲技术
- 批准号:
8636788 - 财政年份:2014
- 资助金额:
$ 24万 - 项目类别:
Mechanisms and Implications of Nanoelectroporation in Living Cells
活细胞纳米电穿孔的机制和意义
- 批准号:
8099680 - 财政年份:2010
- 资助金额:
$ 24万 - 项目类别:
Mechanisms and Implications of Nanoelectroporation in Living Cells
活细胞纳米电穿孔的机制和意义
- 批准号:
7984696 - 财政年份:2010
- 资助金额:
$ 24万 - 项目类别:
Mechanisms and Implications of Nanoelectroporation in Living Cells
活细胞纳米电穿孔的机制和意义
- 批准号:
8500364 - 财政年份:2010
- 资助金额:
$ 24万 - 项目类别:
Mechanisms and Implications of Nanoelectroporation in Living Cells
活细胞纳米电穿孔的机制和意义
- 批准号:
8298579 - 财政年份:2010
- 资助金额:
$ 24万 - 项目类别:
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