Neural mechanisms of spatial representations beyond the self

超越自我的空间表征的神经机制

• 批准号: 10615205
• 负责人: Matthias Stangl
• 金额: $ 11.62万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10615205
• 关键词: Address; Affect; Alzheimer' s Disease; Area; Attention; Award; Awareness; Behavior; Behavioral; Brain; Cells; Clinical; Cognition; Complex; Development; Development Plans; Electrodes; Electrophysiology (science); Environment; Epilepsy; Episodic memory; Frequencies; Future; Goals; Head; Hospitalization; Human; Impairment; Implant; Individual; Institution; Joints; Learning; Location; Measures; Medial; Monitor; Motion; Movement; Nature; Neurologic; Neurons; Partial Epilepsies; Participant; Patients; Persons; Population; Process; Research; Science; Societies; Source; Speed; Symptoms; System; Temporal Lobe; Testing; Therapeutic; Time; Training; Work; animation; career development; cognitive function; effective intervention; experience; flexibility; follow-up; nervous system disorder; neural; neuromechanism; neurophysiology; patient population; skills; social; symposium; therapy development; visual tracking; way finding

PROJECT SUMMARY/ABSTRACT Spatial navigation is a fundamental human behavior, and deficits in navigational functions are among the hallmark symptoms of severe neurological disorders such as Alzheimer’s disease. Understanding how the human brain processes and encodes spatial information is thus of critical importance for the development of therapies for affected patients. Previous studies have shown that the brain forms neural representations of spatial information, via spatially-tuned activity of single neurons (e.g., place cells, grid cells, or head direction cells), and by the coordinated oscillatory activity of cell populations. The vast majority of these studies have focused on the encoding of self-related spatial information, such as one’s own location, orientation, and movements. However, everyday tasks in social settings require the encoding of spatial information not only for oneself, but also for other people in the environment. At present, it is largely unknown how the human brain accomplishes this important function, and how aspects of human cognition may affect these spatial encoding mechanisms. This project therefore aims to elucidate the neural mechanisms that underlie the encoding of spatial information and awareness of others. Specifically, the proposed research plan will determine how human deep brain oscillations and single-neuron activity allow us to keep track of other individuals as they move through our environment. Next, the project will determine whether these spatial encoding mechanisms are specific to the encoding of another person, or whether they can be used more flexibly to support the encoding of moving inanimate objects and even more abstract cognitive functions such as imagined navigation. Finally, the project will determine how spatial information is encoded in more complex real-world scenarios, when multiple information sources (e.g., multiple people) are present. To address these questions, intracranial medial temporal lobe activity will be recorded from two rare participant groups: (1) Participants with permanently implanted depth electrodes for the treatment of focal epilepsy through responsive neurostimulation (RNS), who provide a unique opportunity to record deep brain oscillations during free movement and naturalistic behavior; and (2) hospitalized epilepsy patients with temporarily implanted intracranial electrodes in the epilepsy monitoring unit (EMU), from whom joint oscillatory and single-neuron activity can be recorded. In addition, this award will allow me to complete a multifaceted career development plan: Since my current experience with electrophysiological recordings is limited to oscillatory activity from RNS participants, I will learn to record and analyze human single-neuron activity from EMU patients in a clinical setting. My training will be guided by pioneers in this research area, and will take place at UCLA, one of the world’s leading institutions in the clinical and research work with these patient populations. I will further attend seminars, coursework, and conferences, to develop not only as an experimentalist, but also as an independent leader and science communicator. Together, this will provide me with the necessary set of skills for my transition to independence.

项目总结/文摘

项目成果

Path integration selectively predicts midlife risk of Alzheimer's disease.

路径整合选择性地预测中年阿尔茨海默病的风险。

• DOI: 10.1101/2023.01.31.526473
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Newton,Coco;Pope,Marianna;Rua,Catarina;Henson,Richard;Ji,Zilong;Burgess,Neil;Rodgers,ChristopherT;Stangl,Matthias;Dounavi,Maria-Eleni;Castegnaro,Andrea;Koychev,Ivan;Malhotra,Paresh;Wolbers,Thomas;Ritchie,Karen;Ritchie,CraigW
• 通讯作者: Ritchie,CraigW

Entorhinal grid-like codes and time-locked network dynamics track others navigating through space.

• DOI: 10.1038/s41467-023-35819-3
• 发表时间: 2023-01-31
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Wagner, Isabella C.;Graichen, Luise P.;Todorova, Boryana;Luettig, Andre;Omer, David B.;Stangl, Matthias;Lamm, Claus
• 通讯作者: Lamm, Claus