Johns Hopkins Institute for Clinical and Translational Research

约翰·霍普金斯临床与转化研究所

• 批准号: 10615648
• 负责人: Daniel Ernest Ford
• 金额: $ 696.74万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-31 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10615648
• 关键词: Acceleration; Accident and Emergency department; Address; Alzheimer' s Disease; American; Baltimore; Budgets; Clinic; Clinical Research; Collaborations; Communication; Communities; Complex; Conduct Clinical Trials; Country; Data; Databases; Diagnosis; Dimensions; Disease; Drug Combinations; Ecosystem; Engineering; Environment; Funding; Goals; Health; Health Promotion; Health Status; Health system; Healthcare; Healthcare Systems; Home; Hospitalization; Hospitals; Incentives; Individual; Informatics; Information Systems; Institution; Insurance; Interdisciplinary Study; Intervention; Investments; Joints; Laboratories; Lead; Leadership; Learning; Maryland; Measurable; Medicare; Mentors; Methodology; Mission; Modeling; Multiple Partners; Obesity; Outcome; Pathway interactions; Patients; Pharmacy Schools; Phase; Population; Population Group; Population Heterogeneity; Prevention; Productivity; Public Health; Research; Research Personnel; Research Support; Research Training; Resources; Safety; Science; Scientist; Services; Sexually Transmitted Diseases; Specialist; Speed; Substance abuse problem; Technology; Training; Training Programs; Translating; Translational Research; Translations; Universities; Vision; Work; aspirate; care outcomes; clinical infrastructure; drug development; drug discovery; effective therapy; experience; global health; health care availability; health care delivery; health disparity; improved; individual patient; innovation; investigator training; multidisciplinary; next generation; novel therapeutics; patient population; population health; precision medicine; programs; randomized, clinical trials; responsible research conduct; skills; translational scientist; waiver

Contact PD/PI: Ford, Daniel Ernest The Johns Hopkins Institute for Clinical and Translational Research (ICTR) has been a productive, innovative and impactful organization in transforming how clinical and translational research is conducted throughout Johns Hopkins University. Enhancing collaborative research teams, advancing informatics, promoting new methodologies, providing access to regulatory support, and bringing researchers and the community closer together as true partners in discovery have all made translational research more successful. Over the next five years, the Johns Hopkins ICTR will move beyond its current research community to create a comprehensive regional hub that includes new partners – the University of Maryland Baltimore (UMB), Morgan State University (MSU) and Kaiser Permanente Mid-Atlantic States (KPMAS). These partners bring complementary expertise and connections to distinct populations. Together, we have an opportunity to conduct high quality innovative research, and rapidly implement findings that impact the health of our state and region. Building on our extensive connections with community groups, we will move to a new phase of joint governance with bidirectional communication and participation on key ICTR committees. New programs will include a Trial Innovation Unit that will focus on improving methodologic and operational support for research teams conducting randomized clinical trials so that the impact of these trials is enhanced. A goal of this Unit will be to pilot and disseminate approaches that move randomized clinical trials closer to the precision medicine paradigm, with a focus on outcomes of greatest value to individual patients. Combining drug discovery scientists at Johns Hopkins with experts at the UMB School of Pharmacy, the ICTR will create a new Drug Discovery and Development Core. KPMAS and Johns Hopkins will continue to jointly fund programs that push the boundaries of how a Learning Health Care system can improve health outcomes. The ICTR provides a model for training investigators to work in multidisciplinary teams with experienced mentors using the most rigorous methodologies. We will enhance our training programs by incorporating principles of biodesign from the engineering tradition into the experience of all trainees. This places a higher emphasis on identification of the problem, engaging important stakeholders (clinicians, patients, IT professionals) to develop solutions, and identifying the most effective pathways to dissemination. Translational research demands the skills of many professionals working together to address complex problems. The Johns Hopkins ICTR is poised to leverage our current services to benefit new partners who have extensive responsibility for the conduct of research and health care delivery in Maryland. Working together, we expect to have a measurable impact on translational research in Maryland. Page 679 Project Summary/Abstract Contact PD/PI: Ford, Daniel Ernest By identifying and overcoming barriers in the translational pathway, increasing scientific collaboration, providing consultative services, clinical infrastructure, and technology cores that bridge the gap between the laboratory and the clinic, the ICTR helps to speed the pace of scientific discovery, bringing effective therapies to the public, and ultimately improving the health of Americans. Page 680

联系PD/PI：福特，丹尼尔·欧内斯特

项目成果

Greater Acculturation is Associated With Poorer Cardiovascular Health in the Multi-Ethnic Study of Atherosclerosis.

• DOI: 10.1161/jaha.120.019828
• 发表时间: 2021-04-20
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Osibogun O;Ogunmoroti O;Mathews L;Okunrintemi V;Tibuakuu M;Michos ED
• 通讯作者: Michos ED

Functional Activities Detected in the Olfactory Bulb and Associated Olfactory Regions in the Human Brain Using T2-Prepared BOLD Functional MRI at 7T.

• DOI: 10.3389/fnins.2021.723441
• 发表时间: 2021
• 期刊: Frontiers in neuroscience
• 影响因子: 4.3
• 作者: Miao X;Paez AG;Rajan S;Cao D;Liu D;Pantelyat AY;Rosenthal LI;van Zijl PCM;Bassett SS;Yousem DM;Kamath V;Hua J
• 通讯作者: Hua J

Going beyond affordability for digital equity: Closing the "Digital Divide" through outreach and training programs for older adults.

• DOI: 10.1111/jgs.17511
• 发表时间: 2022-01
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Gleason K;Suen JJ
• 通讯作者: Suen JJ

Dynamics of the infant gut microbiota in the first 18 months of life: the impact of maternal HIV infection and breastfeeding.

婴儿出生后 18 个月内肠道微生物群的动态：母亲 HIV 感染和母乳喂养的影响。

• DOI: 10.1186/s40168-022-01230-1
• 发表时间: 2022-04-12
• 期刊: Microbiome
• 影响因子: 15.5
• 作者: Grant-Beurmann S;Jumare J;Ndembi N;Matthew O;Shutt A;Omoigberale A;Martin OA;Fraser CM;Charurat M
• 通讯作者: Charurat M

Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication.

• DOI: 10.1038/s42255-021-00357-z
• 发表时间: 2021-03
• 期刊: Nature metabolism
• 影响因子: 20.8
• 作者: Jin S;Cao Q;Yang F;Zhu H;Xu S;Chen Q;Wang Z;Lin Y;Cinar R;Pawlosky RJ;Zhang Y;Xiong W;Gao B;Koob GF;Lovinger DM;Zhang L
• 通讯作者: Zhang L