Network-targeted theta-burst stimulation for episodic memory improvement in mild cognitive impairment

网络定向 theta 突发刺激可改善轻度认知障碍的情景记忆

• 批准号: 10614483
• 负责人: ANDREW F LEUCHTER
• 金额: $ 67.73万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614483
• 关键词: Acceleration; Acetylcholine; Adult; Affect; Aftercare; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Astronomy; Atrophic; Behavioral; Brain; Clinical; Cognition Disorders; Complex; Data; Dementia; Deterioration; Development; Discrimination; Dose; Early Intervention; Elderly; Electroencephalography; Episodic memory; Functional Magnetic Resonance Imaging; Generations; Genetic; Genetic Risk; Grant; Health Care Costs; Hippocampus; Human; Incidence; Individual; Individual Differences; Intervention; Lateral; Life; Long-Term Potentiation; Longevity; Measures; Medial; Memory; Memory Disorders; Memory Loss; Memory impairment; Methods; Monitor; Multimodal Imaging; Neurons; Parietal Lobe; Participant; Patients; Persons; Physiological; Prediction of Response to Therapy; Prefrontal Cortex; Randomized; Research; Resolution; Resources; Risk; Rodent; Role; Scalp structure; Site; Societies; Structure; Symptoms; Techniques; Temporal Lobe; Testing; Therapeutic; Therapeutic Intervention; Transcranial magnetic stimulation; age related; amnestic mild cognitive impairment; base; dynamical evolution; follow-up; genetic testing; high risk; image guided; improved; innovation; mild cognitive impairment; neural; neurogenesis; neuroimaging; neuronal circuitry; neuroregulation; novel; novel therapeutic intervention; prevent; programs; progression risk; response; restoration; therapy development; time use; treatment duration; white matter; young adult

Project Summary/Abstract Alzheimer’s Disease (AD) affects millions of people in the US and worldwide, and is becoming an increased burden on individual and society. Individuals with amnestic mild cognitive impairment (aMCI) are at greater risk for development of AD. A reliable method of treatment for individuals with aMCI could help not only to improve the lives of elderly individuals with memory impairment, but also potentially prevent or delay the development of AD. Theta burst transcranial magnetic stimulation (TBS) is a non-invasive neuromodulation method that shows promise for improving memory and may be applied to brain areas that are functionally connected to the hippocampus in order to restore memory function. Because the ability to apply stimulation to modify memory functions depends on the application of stimulation at distinct and specific sites in the complex neuronal circuitry underlying these functions, neuroimaging guided targeting of TBS treatment will provide individualized tailoring of therapeutic intervention needed for maximum efficacy. The proposed project will therefore implement a novel high-resolution functional magnetic resonance imaging (fMRI) guided TBS method to improve hippocampal-cortical connectivity and consequent episodic memory in elderly aMCI individuals with and without genetic risk for AD. Functional MRI, scalp electroencephalography (EEG), and genetic testing will also be used to characterize brain network changes and genetic factors that are associated with TBS related memory restoration. The implications of TBS related memory restoration to patients affected with disorders of memory is of great significance and of urgent need. The proposed project will therefore develop a novel method for memory enhancement, characterize associated brain changes, contribute to the understanding of hippocampal-cortical networks and their role in memory, and ultimately provide a novel therapeutic approach to human memory disorders. The data from this project will demonstrate a proof-of-concept that TBS can be used to improve memory in aMCI, and will launch an emerging and pivotal area of research that will provide therapeutic interventions for patients afflicted with life debilitating cognitive disorders.

项目概要/摘要 阿尔茨海默病 (AD) 影响着美国和全世界数百万人，并且正在成为一种日益严重的疾病 给个人和社会带来负担。患有遗忘型轻度认知障碍 (aMCI) 的个体的风险更大 AD 发展的风险。针对 aMCI 患者的可靠治疗方法不仅可以帮助 改善记忆障碍老年人的生活，同时也有可能预防或延缓记忆障碍的发生 AD的发展。 Theta 突发经颅磁刺激 (TBS) 是一种非侵入性神经调节 该方法有望改善记忆力，并可应用于功能正常的大脑区域 连接到海马体以恢复记忆功能。因为施加刺激的能力 记忆功能的修改取决于复合体中不同和特定位点的刺激应用 这些功能背后的神经元回路，神经影像引导的 TBS 治疗靶向将提供 实现最大疗效所需的个性化治疗干预。拟议的项目将 因此实施一种新颖的高分辨率功能磁共振成像 (fMRI) 引导的 TBS 方法 改善老年 aMCI 个体的海马-皮质连接性和随后的情景记忆 并且没有 AD 的遗传风险。功能性 MRI、头皮脑电图 (EEG) 和基因检测将 也可用于表征与 TBS 相关的大脑网络变化和遗传因素 记忆恢复。 TBS 相关记忆恢复对患有以下疾病的患者的影响 记忆的意义重大，也是迫切需要的。因此，拟议的项目将开发一种新颖的 增强记忆的方法，表征相关的大脑变化，有助于理解 海马皮质网络及其在记忆中的作用，并最终提供一种新的治疗方法 人类记忆障碍。该项目的数据将证明 TBS 可以使用的概念验证 改善 aMCI 的记忆力，并将启动一个新兴的关键研究领域，该领域将提供 对患有使生命衰弱的认知障碍的患者进行治疗干预。