Network-targeted theta-burst stimulation for episodic memory improvement in mild cognitive impairment

网络定向 theta 突发刺激可改善轻度认知障碍的情景记忆

• 批准号: 10035098
• 负责人: ANDREW F LEUCHTER
• 金额: $ 71.48万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10035098
• 关键词: Acetylcholine; Adult; Affect; Aftercare; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Atrophic; Behavioral; Brain; Clinical; Cognition Disorders; Complex; Data; Dementia; Deterioration; Development; Discrimination; Dose; Early Intervention; Elderly; Electroencephalography; Episodic memory; Functional Magnetic Resonance Imaging; Generations; Genetic; Genetic Risk; Grant; Health Care Costs; Hippocampus (Brain); Human; Incidence; Individual; Individual Differences; Intervention; Lateral; Life; Long-Term Potentiation; Longevity; Measures; Medial; Memory; Memory Disorders; Memory Loss; Memory impairment; Methods; Monitor; Multimodal Imaging; Neurons; Parietal Lobe; Participant; Patients; Physiological; Prediction of Response to Therapy; Prefrontal Cortex; Randomized; Research; Resolution; Resources; Risk; Rodent; Role; Scalp structure; Site; Societies; Structure; Symptoms; Techniques; Temporal Lobe; Testing; Therapeutic; Therapeutic Intervention; Transcranial magnetic stimulation; age related; amnestic mild cognitive impairment; apolipoprotein E-4; base; dynamical evolution; follow-up; functional magnetic resonance imaging/electroencephalography; genetic testing; high risk; image guided; improved; innovation; mild cognitive impairment; neurogenesis; neuroimaging; neuronal circuitry; neuroregulation; novel; novel therapeutic intervention; prevent; programs; relating to nervous system; response; restoration; therapy development; time use; treatment duration; white matter; young adult

Project Summary/Abstract Alzheimer’s Disease (AD) affects millions of people in the US and worldwide, and is becoming an increased burden on individual and society. Individuals with amnestic mild cognitive impairment (aMCI) are at greater risk for development of AD. A reliable method of treatment for individuals with aMCI could help not only to improve the lives of elderly individuals with memory impairment, but also potentially prevent or delay the development of AD. Theta burst transcranial magnetic stimulation (TBS) is a non-invasive neuromodulation method that shows promise for improving memory and may be applied to brain areas that are functionally connected to the hippocampus in order to restore memory function. Because the ability to apply stimulation to modify memory functions depends on the application of stimulation at distinct and specific sites in the complex neuronal circuitry underlying these functions, neuroimaging guided targeting of TBS treatment will provide individualized tailoring of therapeutic intervention needed for maximum efficacy. The proposed project will therefore implement a novel high-resolution functional magnetic resonance imaging (fMRI) guided TBS method to improve hippocampal-cortical connectivity and consequent episodic memory in elderly aMCI individuals with and without genetic risk for AD. Functional MRI, scalp electroencephalography (EEG), and genetic testing will also be used to characterize brain network changes and genetic factors that are associated with TBS related memory restoration. The implications of TBS related memory restoration to patients affected with disorders of memory is of great significance and of urgent need. The proposed project will therefore develop a novel method for memory enhancement, characterize associated brain changes, contribute to the understanding of hippocampal-cortical networks and their role in memory, and ultimately provide a novel therapeutic approach to human memory disorders. The data from this project will demonstrate a proof-of-concept that TBS can be used to improve memory in aMCI, and will launch an emerging and pivotal area of research that will provide therapeutic interventions for patients afflicted with life debilitating cognitive disorders.

项目摘要/摘要 阿尔茨海默病(AD)在美国和世界范围内影响着数以百万计的人，并且正在成为一个日益严重的 给个人和社会带来负担。遗忘性轻度认知障碍(AMCI)的个体 阿尔茨海默病发病风险。一种可靠的治疗急性心肌梗死患者的方法不仅有助于 改善有记忆障碍的老年人的生活，但也可能预防或推迟 AD的发展。Theta Burst经颅磁刺激(TBS)是一种非侵入性的神经调节 一种方法，显示出改善记忆的希望，并可能应用于大脑功能区域 连接到海马体，以恢复记忆功能。因为将刺激应用于 修改记忆功能取决于在复合体中不同和特定部位的刺激应用 这些功能背后的神经元电路，神经成像引导的TBS靶向治疗将提供 需要个体化的治疗干预以获得最大的疗效。拟议的项目将 因此，实现了一种新的高分辨率功能磁共振成像(FMRI)引导的TBS方法 改善老年AMCI患者的海马区-皮质连接性和随后的情景记忆 而且没有阿尔茨海默病的遗传风险。功能磁共振成像、头皮脑电(EEG)和基因测试将 也可用于表征与TBS相关的脑网络变化和遗传因素 记忆恢复。TBS相关记忆恢复对精神障碍患者的意义 记忆意义重大，需求迫切。因此，拟议的项目将开发一种新颖的 增强记忆的方法，表征相关的大脑变化，有助于理解 海马-皮质网络及其在记忆中的作用，并最终提供了一种新的治疗方法 人类记忆障碍。来自该项目的数据将证明TBS可以用于 改善aMCI的记忆力，并将启动一个新兴和关键的研究领域，将提供 对患有生命衰弱认知障碍患者的治疗干预。