Network-targeted theta-burst stimulation for episodic memory improvement in mild cognitive impairment
网络定向 theta 突发刺激可改善轻度认知障碍的情景记忆
基本信息
- 批准号:10035098
- 负责人:
- 金额:$ 71.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-15 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AcetylcholineAdultAffectAftercareAgeAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmericanAreaAtrophicBehavioralBrainClinicalCognition DisordersComplexDataDementiaDeteriorationDevelopmentDiscriminationDoseEarly InterventionElderlyElectroencephalographyEpisodic memoryFunctional Magnetic Resonance ImagingGenerationsGeneticGenetic RiskGrantHealth Care CostsHippocampus (Brain)HumanIncidenceIndividualIndividual DifferencesInterventionLateralLifeLong-Term PotentiationLongevityMeasuresMedialMemoryMemory DisordersMemory LossMemory impairmentMethodsMonitorMultimodal ImagingNeuronsParietal LobeParticipantPatientsPhysiologicalPrediction of Response to TherapyPrefrontal CortexRandomizedResearchResolutionResourcesRiskRodentRoleScalp structureSiteSocietiesStructureSymptomsTechniquesTemporal LobeTestingTherapeuticTherapeutic InterventionTranscranial magnetic stimulationage relatedamnestic mild cognitive impairmentapolipoprotein E-4basedynamical evolutionfollow-upfunctional magnetic resonance imaging/electroencephalographygenetic testinghigh riskimage guidedimprovedinnovationmild cognitive impairmentneurogenesisneuroimagingneuronal circuitryneuroregulationnovelnovel therapeutic interventionpreventprogramsrelating to nervous systemresponserestorationtherapy developmenttime usetreatment durationwhite matteryoung adult
项目摘要
Project Summary/Abstract
Alzheimer’s Disease (AD) affects millions of people in the US and worldwide, and is becoming an increased
burden on individual and society. Individuals with amnestic mild cognitive impairment (aMCI) are at greater
risk for development of AD. A reliable method of treatment for individuals with aMCI could help not only to
improve the lives of elderly individuals with memory impairment, but also potentially prevent or delay the
development of AD. Theta burst transcranial magnetic stimulation (TBS) is a non-invasive neuromodulation
method that shows promise for improving memory and may be applied to brain areas that are functionally
connected to the hippocampus in order to restore memory function. Because the ability to apply stimulation to
modify memory functions depends on the application of stimulation at distinct and specific sites in the complex
neuronal circuitry underlying these functions, neuroimaging guided targeting of TBS treatment will provide
individualized tailoring of therapeutic intervention needed for maximum efficacy. The proposed project will
therefore implement a novel high-resolution functional magnetic resonance imaging (fMRI) guided TBS method
to improve hippocampal-cortical connectivity and consequent episodic memory in elderly aMCI individuals with
and without genetic risk for AD. Functional MRI, scalp electroencephalography (EEG), and genetic testing will
also be used to characterize brain network changes and genetic factors that are associated with TBS related
memory restoration. The implications of TBS related memory restoration to patients affected with disorders of
memory is of great significance and of urgent need. The proposed project will therefore develop a novel
method for memory enhancement, characterize associated brain changes, contribute to the understanding of
hippocampal-cortical networks and their role in memory, and ultimately provide a novel therapeutic approach to
human memory disorders. The data from this project will demonstrate a proof-of-concept that TBS can be used
to improve memory in aMCI, and will launch an emerging and pivotal area of research that will provide
therapeutic interventions for patients afflicted with life debilitating cognitive disorders.
项目摘要/摘要
阿尔茨海默病(AD)在美国和世界范围内影响着数以百万计的人,并且正在成为一个日益严重的
给个人和社会带来负担。遗忘性轻度认知障碍(AMCI)的个体
阿尔茨海默病发病风险。一种可靠的治疗急性心肌梗死患者的方法不仅有助于
改善有记忆障碍的老年人的生活,但也可能预防或推迟
AD的发展。Theta Burst经颅磁刺激(TBS)是一种非侵入性的神经调节
一种方法,显示出改善记忆的希望,并可能应用于大脑功能区域
连接到海马体,以恢复记忆功能。因为将刺激应用于
修改记忆功能取决于在复合体中不同和特定部位的刺激应用
这些功能背后的神经元电路,神经成像引导的TBS靶向治疗将提供
需要个体化的治疗干预以获得最大的疗效。拟议的项目将
因此,实现了一种新的高分辨率功能磁共振成像(FMRI)引导的TBS方法
改善老年AMCI患者的海马区-皮质连接性和随后的情景记忆
而且没有阿尔茨海默病的遗传风险。功能磁共振成像、头皮脑电(EEG)和基因测试将
也可用于表征与TBS相关的脑网络变化和遗传因素
记忆恢复。TBS相关记忆恢复对精神障碍患者的意义
记忆意义重大,需求迫切。因此,拟议的项目将开发一种新颖的
增强记忆的方法,表征相关的大脑变化,有助于理解
海马-皮质网络及其在记忆中的作用,并最终提供了一种新的治疗方法
人类记忆障碍。来自该项目的数据将证明TBS可以用于
改善aMCI的记忆力,并将启动一个新兴和关键的研究领域,将提供
对患有生命衰弱认知障碍患者的治疗干预。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANDREW F LEUCHTER其他文献
ANDREW F LEUCHTER的其他文献
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{{ truncateString('ANDREW F LEUCHTER', 18)}}的其他基金
Network-targeted theta-burst stimulation for episodic memory improvement in mild cognitive impairment
网络定向 theta 突发刺激可改善轻度认知障碍的情景记忆
- 批准号:
10383713 - 财政年份:2020
- 资助金额:
$ 71.48万 - 项目类别:
Network-targeted theta-burst stimulation for episodic memory improvement in mild cognitive impairment
网络定向 theta 突发刺激可改善轻度认知障碍的情景记忆
- 批准号:
10260468 - 财政年份:2020
- 资助金额:
$ 71.48万 - 项目类别:
Network-targeted theta-burst stimulation for episodic memory improvement in mild cognitive impairment
网络定向 theta 突发刺激可改善轻度认知障碍的情景记忆
- 批准号:
10614483 - 财政年份:2020
- 资助金额:
$ 71.48万 - 项目类别:
UCLA Clinical Pharmacology Training Program
加州大学洛杉矶分校临床药理学培训计划
- 批准号:
8884612 - 财政年份:2006
- 资助金额:
$ 71.48万 - 项目类别:
Psychobiologic Factors of the Placebo Response in MDD
MDD 安慰剂反应的心理生物学因素
- 批准号:
7247100 - 财政年份:2004
- 资助金额:
$ 71.48万 - 项目类别:
Psychobiologic Factors of the Placebo Response in MDD
MDD 安慰剂反应的心理生物学因素
- 批准号:
7076106 - 财政年份:2004
- 资助金额:
$ 71.48万 - 项目类别:
Psychobiologic Factors of the Placebo Response in MDD
MDD 安慰剂反应的心理生物学因素
- 批准号:
6838569 - 财政年份:2004
- 资助金额:
$ 71.48万 - 项目类别:
Psychobiologic Factors of the Placebo Response in MDD
MDD 安慰剂反应的心理生物学因素
- 批准号:
6952261 - 财政年份:2004
- 资助金额:
$ 71.48万 - 项目类别:
PSYCHIATRIC ASSESSMENT OF COGNITION IN THE ELDERLY
老年人认知的精神病学评估
- 批准号:
2240634 - 财政年份:1994
- 资助金额:
$ 71.48万 - 项目类别:
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