Network-targeted theta-burst stimulation for episodic memory improvement in mild cognitive impairment

网络定向 theta 突发刺激可改善轻度认知障碍的情景记忆

• 批准号: 10260468
• 负责人: ANDREW F LEUCHTER
• 金额: $ 67.32万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10260468
• 关键词: Acetylcholine; Adult; Affect; Aftercare; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Atrophic; Behavioral; Brain; Clinical; Cognition Disorders; Complex; Data; Dementia; Deterioration; Development; Discrimination; Dose; Early Intervention; Elderly; Electroencephalography; Episodic memory; Functional Magnetic Resonance Imaging; Generations; Genetic; Genetic Risk; Grant; Health Care Costs; Hippocampus (Brain); Human; Incidence; Individual; Individual Differences; Intervention; Lateral; Life; Long-Term Potentiation; Longevity; Measures; Medial; Memory; Memory Disorders; Memory Loss; Memory impairment; Methods; Monitor; Multimodal Imaging; Neurons; Parietal Lobe; Participant; Patients; Physiological; Prediction of Response to Therapy; Prefrontal Cortex; Randomized; Research; Resolution; Resources; Risk; Rodent; Role; Scalp structure; Site; Societies; Structure; Symptoms; Techniques; Temporal Lobe; Testing; Therapeutic; Therapeutic Intervention; Transcranial magnetic stimulation; age related; amnestic mild cognitive impairment; apolipoprotein E-4; base; dynamical evolution; follow-up; functional magnetic resonance imaging/electroencephalography; genetic testing; high risk; image guided; improved; innovation; mild cognitive impairment; neurogenesis; neuroimaging; neuronal circuitry; neuroregulation; novel; novel therapeutic intervention; prevent; programs; relating to nervous system; response; restoration; therapy development; time use; treatment duration; white matter; young adult

Project Summary/Abstract Alzheimer’s Disease (AD) affects millions of people in the US and worldwide, and is becoming an increased burden on individual and society. Individuals with amnestic mild cognitive impairment (aMCI) are at greater risk for development of AD. A reliable method of treatment for individuals with aMCI could help not only to improve the lives of elderly individuals with memory impairment, but also potentially prevent or delay the development of AD. Theta burst transcranial magnetic stimulation (TBS) is a non-invasive neuromodulation method that shows promise for improving memory and may be applied to brain areas that are functionally connected to the hippocampus in order to restore memory function. Because the ability to apply stimulation to modify memory functions depends on the application of stimulation at distinct and specific sites in the complex neuronal circuitry underlying these functions, neuroimaging guided targeting of TBS treatment will provide individualized tailoring of therapeutic intervention needed for maximum efficacy. The proposed project will therefore implement a novel high-resolution functional magnetic resonance imaging (fMRI) guided TBS method to improve hippocampal-cortical connectivity and consequent episodic memory in elderly aMCI individuals with and without genetic risk for AD. Functional MRI, scalp electroencephalography (EEG), and genetic testing will also be used to characterize brain network changes and genetic factors that are associated with TBS related memory restoration. The implications of TBS related memory restoration to patients affected with disorders of memory is of great significance and of urgent need. The proposed project will therefore develop a novel method for memory enhancement, characterize associated brain changes, contribute to the understanding of hippocampal-cortical networks and their role in memory, and ultimately provide a novel therapeutic approach to human memory disorders. The data from this project will demonstrate a proof-of-concept that TBS can be used to improve memory in aMCI, and will launch an emerging and pivotal area of research that will provide therapeutic interventions for patients afflicted with life debilitating cognitive disorders.

项目摘要/摘要 阿尔茨海默氏病（AD）影响了美国和全球数以百万计的人，并且正在增加 负担个人和社会。具有柔滑轻度认知障碍（AMCI）的个体越来越大 发展广告的风险。一种可靠的AMCI个体治疗方法，不仅可以帮助 改善有记忆力障碍的小学个人的生活，但也有可能预防或延迟 广告的开发。 theta爆发trancranial磁刺激（TBS）是一种非侵入性神经调节 显示有望改善记忆的方法，可以应用于功能上的大脑区域 连接到海马，以恢复内存功能。因为将刺激应用于 修改内存功能取决于在复合物中不同和特定位点的刺激的应用 这些功能的基础神经元电路，神经成像的指导靶向TBS治疗将提供 最高效率所需的治疗干预措施的个性化剪裁。拟议的项目将 因此，实施了一种新型的高分辨率功能磁共振成像（fMRI）指导TBS方法 改善海马 - 皮层连通性和随之而来的amci个体的情节记忆 并且没有AD的遗传风险。功能性MRI，头皮脑电图（EEG）和基因测试将 还用于表征与与TBS相关的与TBS相关的大脑网络变化和遗传因素 记忆恢复。与TBS相关记忆的影响对患有影响的患者 记忆具有重要意义和迫切需求。因此，拟议的项目将开发出小说 记忆增强的方法，表征相关的大脑变化，有助于理解 海马领域网络及其在记忆中的作用，并最终提供了一种新颖的治疗方法 人类记忆障碍。该项目的数据将证明可以使用TBS的概念证明 为了改善AMCI的记忆，并将推出新兴和关键的研究领域 患有生活使认知障碍的患者的治疗干预措施。