eHaRT-A: Adapting an evidence-based, in-person harm reduction treatment into a virtual care telehealth intervention for people with lived experience of homelessness and alcohol use disorder

eHarT-A：将基于证据的面对面减少伤害治疗转变为针对有无家可归和酒精使用障碍生活经历的人的虚拟护理远程医疗干预

• 批准号: 10590521
• 负责人: Tessa Marie Frohe
• 金额: $ 17.46万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-13 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590521
• 关键词: Abstinence; Address; Advocacy; Affect; Alcohol consumption; Alcohols; Award; COVID-19; Case Management; Client; Clinical; Collaborations; Communities; Complement; Consensus; Development; Discipline of Nursing; Enhancement Technology; Feedback; Focus Groups; Foundations; Funding; General Population; Glucuronides; Goals; Grant; Harm Reduction; Health; Healthcare; High Prevalence; Homelessness; Housing; Individual; Intervention; Measurement; Mentored Research Scientist Development Award; Mentors; Methods; Mission; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Online Systems; Outcome; Pain; Participant; Patient Self-Report; Patients; Persons; Phase; Population; Positioning Attribute; Qualitative Methods; Quality of life; Randomized Controlled Trials; Research; Research Personnel; Research Priority; Research Project Grants; Research Training; Risk Factors; Scientist; Series; Service provision; Services; Symptoms; Technology; Testing; Time; Training; United States National Institutes of Health; Universities; Videoconferencing; Vulnerable Populations; Walking; Washington; Writing; acceptability and feasibility; alcohol abuse therapy; alcohol availability; alcohol intervention; alcohol research; alcohol use disorder; arm; base; career; clinically relevant; community based participatory research; community setting; comparative efficacy; design; digital; drinking; efficacy testing; evidence base; experience; feasibility testing; global health; health related quality of life; implementation intervention; improved; innovation; intervention delivery; marginalized community; mortality; online intervention; pandemic disease; post-doctoral training; prototype; recruit; reduced substance use; research data dissemination; service gap; services as usual; skills; standard of care; statistics; substance use; substance use treatment; supported housing; telehealth; telehealthcare; therapy development; treatment research; treatment services; urinary; usability; user centered design; virtual healthcare; vulnerable community

Project Summary/Abstract The long-term objective of this K01 Mentored Research Scientist Development Award is to support Dr. Tessa Frohe, in building an independent research career focused on adapting, designing, and implementing efficacious telehealth alcohol interventions among marginalized communities. To date, Dr. Frohe’s research has focused on risk factors associated with pain and substance use. During her postdoctoral training, she has begun working within a community-based and qualitative methods framework to examine alcohol use specifically among people experiencing homelessness and AUD; however, Dr. Frohe seeks to expand her training from basic alcohol research to implementing and testing technology-based interventions informed by community stakeholders and user-centered design to improve treatment delivery among this population. This long-term objective will be achieved through a five-year training and research plan involving a carefully selected mentor team, targeted coursework, and hands-on training experiences. The proposed research aims to adapt an in-person harm reduction intervention (HaRT-A) into a telehealth platform (eHaRT-A) and test it among individuals with lived experience of homelessness and AUD. This project will occur in two phases: Phase 1 will entail codevelopment with iterative usability testing of the telehealth platform with a community advisory board (e.g., Housing First residents) to leverage stakeholder ideas to inform and build the eHaRT-A prototype (Aim 1) and to make design changes that will improve the feasibility and acceptability of the eHaRT-A platform (Aim 2). In Phase 2, a randomized controlled trial will be conducted to test the efficacy of eHaRT-A compared to “supportive services as usual” in improving alcohol-related outcomes (i.e., peak alcohol use, alcohol-related harm, AUD symptoms, and positive urinary ethyl glucuronide tests) and health related quality of life over time (Aim 3). This proposal aligns with national (NIH; NOT-AA-20-011) health initiatives to integrate technology-based interventions for vulnerable and marginalized communities with pre-existing substance use treatments. If successful, this study will develop a clinically relevant intervention that is more easily transportable to marginalized community settings because it will be developed for, by, and with the community it aims to serve. The training plan for this application will focus on intervention development and testing, innovative methods to enhance technology-based intervention implementation, and advanced statistics. Mentors (Drs. Clifasefi, Collins, Comtois, Hsieh) and collaborators (Drs. Larimer, Hallgren) are committed to Dr. Frohe’s training and each will provide unique expertise to her proposed research and training plan. Support from this award will be essential to Dr. Frohe’s development as an independent scientist who can contribute to alcohol research by codeveloping, adapting, and testing successful technology-based interventions to ameliorate alcohol-related harm and improve individuals’ quality of life. The University of Washington is well suited to provide a stellar training experience and will promote NIH’s mission to develop early investigators who can be competitive for long-term research funding.

项目摘要/摘要 这个K01指导研究科学家发展奖的长期目标是支持Tessa博士 Frohe，在建立一个独立的研究职业中，专注于适应，设计和实施高效 边缘化社区的远程医疗饮酒干预措施。迄今为止，Frohe博士的研究重点是 与疼痛和药物使用相关的风险因素。在博士后培训期间，她已经开始工作 在一个基于社区和定性的方法框架中，以专门研究酒精的使用 经历无家可归和音调；但是，Frohe博士试图将培训从基本酒精中扩展 研究和测试基于技术的干预措施的研究，由社区利益相关者和 以用户为中心的设计，以改善该人群中的治疗。这个长期目标将是 通过为期五年的培训和研究计划实现了一个精心挑选的心理团队，目标是 课程和动手培训经验。拟议的研究旨在适应面对面的伤害 将干预措施（HART-A）减少到远程医疗平台（EHART-A），并在有生活的人中进行测试 无家可归和音调的经验。该项目将分为两个阶段：第1阶段将需要代码开发 通过社区咨询委员会对远程医疗平台进行迭代可用性测试（例如，住房首先 居民）利用利益相关者的想法来告知和构建Ehart-A原型（AIM 1）并进行设计 将改善Ehart-A平台的可行性和可接受性的变化（AIM 2）。在第2阶段 与“支持服务”相比，将进行随机对照试验以测试EHART-A的效率 像往常 随着时间的推移，阳性尿乙二醇测试和与健康相关的生活质量（AIM 3）。 该提案与国家（NIH； NOT-AA-20-011）健康计划保持一致，以整合基于技术的 对脆弱和边缘化社区的干预措施，并具有先前存在的物质使用治疗。如果 成功，这项研究将开发出与临床相关的干预措施，更容易运输到 边缘化的社区环境是因为它将为其旨在服务的社区开发，并与社区开发。 该应用程序的培训计划将着重于干预开发和测试，创新方法 增强基于技术的干预实施和高级统计。导师（Clifasefi博士，Collins， Comtois，HSIEH）和合作者（Hallgren博士）致力于Frohe博士的培训，每个人都将 为她提出的研究和培训计划提供独特的专业知识。该奖项的支持将是必不可少的 对于弗罗（Frohe）博士作为独立科学家的发展，他可以通过编码开发， 适应和测试成功的基于技术的干预措施以减轻与酒精有关的危害并改善 个人的生活质量。华盛顿大学非常适合提供出色的培训经验和 将促进NIH的使命，即发展可以在长期研究资金中具有竞争力的早期研究人员。