Ethical Implementation of Social Epigenomics Research on Asthma in a Health Disparity Population
健康差异人群哮喘社会表观基因组学研究的伦理实施
基本信息
- 批准号:10593404
- 负责人:
- 金额:$ 15.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-26 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAfrican AmericanAfrican American populationAsthmaAttentionAttitudeAwardBenefits and RisksBioethical IssuesBioethicsBiologicalBiomedical ResearchChildChildhoodChronicChronic DiseaseChronic stressCollectionCommunitiesConsentDevelopmentDiseaseEnsureEnvironmental ExposureEpigenetic ProcessEthical IssuesEthicsExposure toFamilyFocus GroupsFunctional disorderFutureGeneticHealthHispanicImmune responseImmunityIndividualInformation DisseminationInformed ConsentInstitutionInterventionInterviewInvestigationLeadLinkMedical ResearchMethodsMinority GroupsModificationMorbidity - disease rateNot Hispanic or LatinoParentsParticipantPathway interactionsPersonal SatisfactionPlayPoliciesPopulationPopulation GroupPopulation StudyPrevalenceProceduresPublicationsPublishingReduce health disparitiesReportingResearchRhinovirusRhinovirus infectionRiskRisk BehaviorsRoleSamplingSeriesSocial PerceptionStereotypingStigmatizationStressStructural RacismTimeTrustUnited StatesViralVirus DiseasesVulnerable Populationsadverse childhood eventsasthma exacerbationcare seekingdata sharingdisorder riskepigenomicsevidence baseexperiencegenomic datahealth disparityhealth disparity populationsinfection riskintergenerationalmarginalized communitymemberparent projectprecision medicineprogramspsychosocialracial discriminationracial disparityracial minorityracismrecruitresponserisk minimizationsocialsocial genomicssocial health determinantssocial implicationsocial integrationsocial stigmastressorstudy populationsystems research
项目摘要
SUMMARY
Asthma is the most common chronic childhood condition and exacerbations are often linked to a rhinovirus
infection. Asthma shows significant health disparities, with greater prevalence and morbidity in African American
children than in white non-Hispanic children, but the underlying causes of this disparity is not well understood.
Our ongoing parent award, abbreviated as the “Stress, Epigenomics and Asthma” (SEA) study seeks to explore
a mechanism for previously published links between chronic stress experienced by racial minorities and asthma
risk and morbidity through studying the impacts of chronic stress on epigenomic changes affecting immune
response to viral infections such as rhinoviruses. Unraveling the mechanism by which chronic stress may alter
immunity and, in turn, asthma risk offers potential targets for the development of precision medicine interventions
that could address health disparities. Yet, the linking of negative social experiences to biological changes,
particularly in a population that already experiences racism holds potential psychosocial risks for participants
and risks of unintended group harm to a vulnerable population. This supplement proposes to add a bioethics
research component to the SEA study to explore the unique bioethical issues in the emerging field of social
epigenomics. In-depth interviews with parent participants in the SEA study will explore participant experiences
with the study and their attitudes about social epigenomic research in asthma and beyond. The study of reasons
eligible families decline participation in the SEA study will further explore concerns about the research in the
eligible study population. Additionally, focus groups held with members of the African American community will
use the parent award as an example to investigate attitudes in this historically marginalized community about
social epigenomics, potential benefits and risks of this line of research, and strategies for minimizing risks of
unintended population group harms. This supplement will support bioethics research on social epigenomics
investigations to provide an evidence base to inform future policy around ethical issues including informed
consent, the collection and linking of sensitive social and genomic information, and dissemination of findings
through publication and data sharing in ways that protect vulnerable populations.
总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Elin Grundberg其他文献
Elin Grundberg的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Elin Grundberg', 18)}}的其他基金
Understanding Mechanisms Underlying Chronic Stress-Induced Asthma in Children by Population and Single-Cell Epigenomics Approaches
通过群体和单细胞表观基因组学方法了解儿童慢性压力诱发哮喘的机制
- 批准号:
10053566 - 财政年份:2020
- 资助金额:
$ 15.48万 - 项目类别:
Understanding Mechanisms Underlying Chronic Stress-Induced Asthma in Children by Population and Single-Cell Epigenomics Approaches
通过群体和单细胞表观基因组学方法了解儿童慢性压力诱发哮喘的机制
- 批准号:
10247824 - 财政年份:2020
- 资助金额:
$ 15.48万 - 项目类别:
Understanding Mechanisms Underlying Chronic Stress-Induced Asthma in Children by Population and Single-Cell Epigenomics Approaches
通过群体和单细胞表观基因组学方法了解儿童慢性压力诱发哮喘的机制
- 批准号:
10610862 - 财政年份:2020
- 资助金额:
$ 15.48万 - 项目类别:
Understanding Mechanisms Underlying Chronic Stress-Induced Asthma in Children by Population and Single-Cell Epigenomics Approaches
通过群体和单细胞表观基因组学方法了解儿童慢性压力诱发哮喘的机制
- 批准号:
10393705 - 财政年份:2020
- 资助金额:
$ 15.48万 - 项目类别:
Contextualizing and Addressing Population-Level Bias in Social Epigenomics Study of Asthma in Childhood
儿童哮喘社会表观基因组学研究中的背景分析和解决人群水平偏差
- 批准号:
10593797 - 财政年份:2020
- 资助金额:
$ 15.48万 - 项目类别:
Environmental Exposures, AHR Activation, and Placental Origins of Development
环境暴露、AHR 激活和胎盘发育起源
- 批准号:
10413959 - 财政年份:2018
- 资助金额:
$ 15.48万 - 项目类别:
Environmental Exposures, AHR Activation, and Placental Origins of Development
环境暴露、AHR 激活和胎盘发育起源
- 批准号:
10176489 - 财政年份:2018
- 资助金额:
$ 15.48万 - 项目类别:
相似海外基金
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 15.48万 - 项目类别:
Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 15.48万 - 项目类别:
Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 15.48万 - 项目类别:
Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 15.48万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 15.48万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 15.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 15.48万 - 项目类别:
Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
- 批准号:
2301846 - 财政年份:2023
- 资助金额:
$ 15.48万 - 项目类别:
Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 15.48万 - 项目类别:
Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
- 批准号:
23K16076 - 财政年份:2023
- 资助金额:
$ 15.48万 - 项目类别:
Grant-in-Aid for Early-Career Scientists














{{item.name}}会员




