Mentoring and Patient-Oriented Research on Social Exposures and CVD Risk in Underrepresented Women

针对代表性不足的女性的社会暴露和心血管疾病风险的指导和以患者为导向的研究

• 批准号: 10616599
• 负责人: Tené T Lewis
• 金额: $ 12.38万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10616599
• 关键词: Acceleration; African American; Age; Aging; Animal Model; Antral; Automobile Driving; Award; Biological Assay; Biological Markers; Blood specimen; Body mass index; Cardiology; Cardiovascular Diseases; Chronology; Collaborations; Consultations; Data; Development; Discipline; Discrimination; Disease; Doctor of Philosophy; Education; Educational workshop; Emotional; Epidemiology; Estrogens; Exposure to; Family; Fellowship Program; Female; Financial Hardship; Follicle Stimulating Hormone; Fostering; Friends; Funding; Future; Genetic; Goals; Grant; Health; Health Services Accessibility; Hormones; Knowledge; Link; Master of Public Health; Measures; Menopause; Menstrual cycle; Mentors; Meta-Analysis; Midcareer Investigator Award in Patient-Oriented Research; Modeling; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Outcome; Ovarian; Ovarian aging; Parents; Physiologic pulse; Physiological; Pilot Projects; Populations at Risk; Premature Menopause; Premenopause; Process; Public Health Schools; Records; Reporting; Research; Research Personnel; Risk Factors; Science; Smoking; Socioeconomic Status; Study of Women' s Health Across the Nation; Subgroup; System; Time; Training; Training Programs; Underrepresented Populations; Universities; Vulnerable Populations; Weather; Woman; Women' s Group; Women' s Health; aged; black/white disparity; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; career; cohort; design; diminished ovarian reserve; ethnic minority; health inequalities; interest; intima media; medical schools; men; middle age; minority scientist; mortality; mullerian-inhibiting hormone; multidisciplinary; multimodality; nonhuman primate; ovarian reserve; patient oriented; patient oriented research; programs; prospective; racial minority; reproductive; skills; social; social stress; social stressor; sociodemographics; stress management; supportive environment; therapy design; ultrasound

PROJECT SUMMARY This Mid-Career Investigator Award in Patient-Oriented Research is designed to provide Dr. Tené T. Lewis with protected time and other support to: 1) advance her current program of research, focused on understanding how social stressors contribute to cardiovascular disease (CVD) risk in underrepresented and understudied groups of women; 2) accelerate a successful record of mentoring junior patient-oriented researchers across disciplines, with an emphasis on trainees historically underrepresented in research (e.g. racial/ethnic minority scientists); 3) enhance her mentoring skills, with a particular focus on transdisciplinary approaches and best-practices in providing mentoring and support to underrepresented groups; and 4) obtain training in the examination of biomarkers of ovarian aging, as emerging risk factors for CVD in women. Mentoring activities will leverage Dr. Lewis’ ongoing involvement in several training programs at Emory University, including an NHLBI-funded multidisciplinary T32 training grant on cardiovascular health inequities that she co-directs, the research-track Cardiology fellowship program at the School of Medicine, and the Master of Public Health and PhD programs in Epidemiology at the Rollins School of Public Health. Mentoring training will occur via workshops and regular consultation with senior investigators with established track records in mentoring of patient-oriented researchers from a range of disciplinary and sociodemographic backgrounds. Training in ovarian aging will build upon Dr. Lewis’ existing collaborations at Emory and with the Study of Women’s Health Across the Nation (SWAN). Finally, the science proposed in the award will extend Dr. Lewis’ research in critically important new directions, by examining ovarian aging as a biologically plausible mechanism that might further contribute to our understanding of how social stressors impact subclinical CVD in vulnerable subgroups of women (particularly African-American women) highlighting processes occurring at midlife, when excess rates are most pronounced.

项目摘要 这项以患者为导向的研究中的职业生涯研究者奖旨在为Tené T博士提供。刘易斯 与保护的时间和其他支持：1）推进她目前的研究计划，重点是 了解社会压力如何导致心血管疾病（CVD）风险， 未充分研究的妇女群体; 2）加速指导初级患者导向的成功记录 跨学科的研究人员，重点是历史上在研究中代表性不足的学员（例如， 种族/少数民族科学家）; 3）提高她的指导技能，特别注重跨学科 为代表性不足的群体提供指导和支持的方法和最佳做法;以及4）获得 培训检查卵巢老化的生物标志物，作为女性心血管疾病的新风险因素。 指导活动将利用刘易斯博士在埃默里大学的几个培训项目的持续参与 大学，包括NHLBI资助的关于心血管健康不公平的多学科T32培训补助金 她是医学院心脏病学研究奖学金项目的共同负责人， 罗林斯公共卫生学院公共卫生硕士和流行病学博士课程。辅导 培训将通过讲习班和定期与具有既定轨道的高级调查员协商进行 指导来自一系列学科和社会人口学的以患者为导向的研究人员的记录 背景卵巢老化的培训将建立在刘易斯博士在埃默里大学现有的合作基础上， 全国妇女健康研究。最后，奖项中提出的科学将延伸到 博士刘易斯的研究在至关重要的新方向，通过检查卵巢老化作为一个生物学上合理的， 这一机制可能进一步有助于我们理解社会压力如何影响亚临床CVD， 妇女（特别是非洲裔美国妇女）的弱势群体，强调在 中年，当超额率最明显。