Mentoring and Patient-Oriented Research on Social Exposures and CVD Risk in Underrepresented Women

针对代表性不足的女性的社会暴露和心血管疾病风险的指导和以患者为导向的研究

• 批准号: 10440016
• 负责人: Tené T Lewis
• 金额: $ 12.38万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10440016
• 关键词: African American; Age; Animal Model; Antral; Automobile Driving; Award; Biological Assay; Biological Markers; Blood specimen; Body mass index; Cardiology; Cardiovascular Diseases; Chronology; Collaborations; Consultations; Data; Development; Discipline; Discrimination; Disease; Doctor of Philosophy; Education; Educational workshop; Emotional; Epidemiology; Estrogens; Exposure to; Family; Fellowship Program; Female; Financial Hardship; Follicle Stimulating Hormone; Fostering; Friends; Funding; Future; Genetic; Goals; Grant; Health; Health Services Accessibility; Hormones; Knowledge; Link; Master of Public Health; Measures; Menopause; Menstrual cycle; Mentors; Meta-Analysis; Modeling; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Outcome; Ovarian; Ovarian aging; Parents; Physiologic pulse; Physiological; Pilot Projects; Play; Premature Menopause; Premenopause; Process; Public Health Schools; Records; Reporting; Research; Research Personnel; Risk; Risk Factors; Role; Science; Smoking; Socioeconomic Status; Study of Women' s Health Across the Nation; Subgroup; System; Time; Training; Training Programs; Underrepresented Populations; Universities; Vulnerable Populations; Weather; Woman; Women' s Group; Women' s Health; aged; black/white disparity; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; career; cohort; design; diminished ovarian reserve; health inequalities; interest; intima media; medical schools; men; middle age; minority scientist; mortality; mullerian-inhibiting hormone; multidisciplinary; multimodality; nonhuman primate; ovarian reserve; patient oriented; patient oriented research; programs; prospective; racial and ethnic; reproductive; reproductive senescence; skills; social; social stress; social stressor; sociodemographics; stress management; supportive environment; therapy design; ultrasound

PROJECT SUMMARY This Mid-Career Investigator Award in Patient-Oriented Research is designed to provide Dr. Tené T. Lewis with protected time and other support to: 1) advance her current program of research, focused on understanding how social stressors contribute to cardiovascular disease (CVD) risk in underrepresented and understudied groups of women; 2) accelerate a successful record of mentoring junior patient-oriented researchers across disciplines, with an emphasis on trainees historically underrepresented in research (e.g. racial/ethnic minority scientists); 3) enhance her mentoring skills, with a particular focus on transdisciplinary approaches and best-practices in providing mentoring and support to underrepresented groups; and 4) obtain training in the examination of biomarkers of ovarian aging, as emerging risk factors for CVD in women. Mentoring activities will leverage Dr. Lewis’ ongoing involvement in several training programs at Emory University, including an NHLBI-funded multidisciplinary T32 training grant on cardiovascular health inequities that she co-directs, the research-track Cardiology fellowship program at the School of Medicine, and the Master of Public Health and PhD programs in Epidemiology at the Rollins School of Public Health. Mentoring training will occur via workshops and regular consultation with senior investigators with established track records in mentoring of patient-oriented researchers from a range of disciplinary and sociodemographic backgrounds. Training in ovarian aging will build upon Dr. Lewis’ existing collaborations at Emory and with the Study of Women’s Health Across the Nation (SWAN). Finally, the science proposed in the award will extend Dr. Lewis’ research in critically important new directions, by examining ovarian aging as a biologically plausible mechanism that might further contribute to our understanding of how social stressors impact subclinical CVD in vulnerable subgroups of women (particularly African-American women) highlighting processes occurring at midlife, when excess rates are most pronounced.

项目总结 这个以患者为中心的研究的职业中期研究人员奖旨在为TenéT.Lewis博士提供 利用受保护的时间和其他支持：1)推进她目前的研究计划，重点是 了解社会应激源如何在代表性不足和 未得到充分研究的妇女群体；2)加快以病人为导向的初级指导的成功记录 不同学科的研究人员，重点是历来在研究中代表性不足的受训人员(例如 种族/少数民族科学家)；3)提高她的指导技能，特别是跨学科 向任职人数不足的群体提供指导和支助的方法和最佳做法；以及4)获得 卵巢老化生物标记物作为女性心血管疾病新的危险因素的检查培训。 指导活动将利用刘易斯博士正在参与的埃默里大学的几个培训项目 大学，包括NHLBI资助的关于心血管健康不平等的多学科T32培训赠款 她是医学院心脏病学研究跟踪奖学金计划的共同负责人，以及 罗林斯公共卫生学院公共卫生硕士和流行病学博士项目。辅导 培训将通过讲习班进行，并定期与有既定轨道的高级调查人员进行磋商 从不同学科和社会人口统计学角度指导以病人为中心的研究人员的记录 背景。卵巢老化方面的培训将建立在刘易斯博士在埃默里大学和 全国妇女健康研究(SWAN)。最后，奖项中提出的科学将延伸到 刘易斯博士在至关重要的新方向上的研究，通过检查卵巢衰老在生物学上是可行的 这一机制可能有助于我们进一步了解社会应激源如何影响亚临床心血管疾病 弱势妇女亚群(特别是非裔美国妇女)强调在 中年，超额利率最明显的时候。