Decoding Prior Bias in Psychosis Using Population Receptive Fields

使用群体感受野解码精神病的先验偏差

• 批准号: 10616728
• 负责人: Kenneth Wengler
• 金额: $ 8.31万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10616728
• 关键词: Affect; Auditory; Auditory Hallucination; Auditory area; Behavioral; Behavioral Mechanisms; Characteristics; Clinical; Computer Models; Data; Decision Making; Development; Diagnostic; Discrimination; Event; Experimental Designs; Feedback; Form Perception; Frequencies; Functional Magnetic Resonance Imaging; Goals; Hallucinations; Image; Impairment; Individual; Knowledge; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Modeling; Motion; Neurobiology; Neurologic Symptoms; Neurons; Neurosciences; Noise; Patients; Perception; Population; Process; Psychiatry; Psychophysics; Psychoses; Research; Rewards; Schizophrenia; Sensory; Severities; Signal Transduction; Speech; Stimulus; Symptoms; Syndrome; Techniques; Training; Visual; Width; Work; base; clinically relevant; disability; expectation; magnetic resonance imaging biomarker; neural; neurobiological mechanism; neurofeedback; neuromechanism; novel; novel therapeutics; programs; psychotic; receptive field; response; retinotopic; sound; tool; years of life lost

PROJECT SUMMARY Schizophrenia is an exceedingly prevalent and burdensome illness that affects ~26 million individuals world-wide and accounts for ~16 million years of life lost due to disability per year. A characteristic symptom of schizophrenia is auditory hallucinations, occurring in ~80% of patients with ~30% of sufferers unresponsive to available treatments. Despite their impact, the neural mechanisms of auditory hallucinations are poorly understood. Auditory hallucinations are thought to arise from greater bias towards prior knowledge when forming perceptions (prior bias). Prior bias is the incorporation of prior knowledge into percepts that biases perception towards more likely sensory events. Previous studies using single-unit recordings during perceptual decision-making tasks have probed the neural manifestation of prior bias. A major finding of this work is that behavioral bias for a stimulus feature (e.g. leftward motion vs rightward motion) is associated with greater activity in neurons with receptive fields tuned to that stimulus feature. To probe the neural mechanisms of prior bias it is thus critical to define the tuning of receptive fields and design experiments that capitalize on this tuning (Aim 1). Population receptive field (pRF) mapping is a novel fMRI method that allows definition of neural tuning in auditory and visual regions with tonotopic and retinotopic organization, respectively. For example, tonotopic pRF mapping can define regions that are macroscopically organized with ensembles of neurons tuned to a specific tone frequency. By combining tonotopic pRF with a behavioral task to probe perceptual biases in tone frequency a direct measurement of the neural mechanisms of prior bias in auditory hallucinations can be developed (Aim 2). In Aim 1 we will use pRF tonotopic mapping to define the tonotopic organization of the auditory cortex in unmedicated patients with schizophrenia (N=30) and investigate differences compared to matched healthy controls (N=30). We hypothesize that the severity of auditory hallucinations will be correlated with broader pRF tuning in the associative auditory cortex. In Aim 2 we will determine the neural representation of prior bias in auditory hallucinations by acquiring fMRI during a two-tone frequency discrimination task in the same unmedicated schizophrenia patients and matched healthy controls from Aim 1. This task elicits prior bias that will be directly measured by using the tonotopic maps acquired in Aim 1 to localize activation to specific frequencies. We hypothesize that prior bias will manifest in the fMRI signal as an over-activation of the pRF's tuned to the prior information and that the degree of over-activation will correlate with the severity of auditory hallucinations.

项目总结

项目成果

Probing midbrain dopamine function in pediatric obsessive-compulsive disorder via neuromelanin-sensitive magnetic resonance imaging.

通过神经素敏感的磁共振成像探测小儿强迫症的中脑多巴胺功能。

• DOI: 10.1038/s41380-023-02105-z
• 发表时间: 2023-07
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Pagliaccio, David;Wengler, Kenneth;Durham, Katherine;Fontaine, Martine;Rueppel, Meryl;Becker, Hannah;Bilek, Emily;Pieper, Sarah;Risdon, Caroline;Horga, Guillermo;Fitzgerald, Kate D.;Marsh, Rachel
• 通讯作者: Marsh, Rachel

Standardized Data Acquisition for Neuromelanin-sensitive Magnetic Resonance Imaging of the Substantia Nigra.

• DOI: 10.3791/62493
• 发表时间: 2021-09-08
• 期刊: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
• 影响因子: 1.2
• 作者: Salzman, Garrett;Kim, Jocelyn;Horga, Guillermo;Wengler, Kenneth
• 通讯作者: Wengler, Kenneth