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Neural Dynamics Underlying Feeding

喂养背后的神经动力学

基本信息

批准号：
10616817
负责人：
Zachary A. Knight
金额：
$ 50.98万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-20 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10616817
关键词：
Abdomen Ablation Address Animals Behavior Bite Blood Body Weight Brain Brain Stem Brain region Calcium Chemicals Cholecystokinin Consumption Cues Decerebration procedure Dependence Diet Eating Elements Feedback Feeding behaviors Food Gastrointestinal tract structure Hormonal Hormones Infusion procedures Ingestion Intestines Knowledge Learning Liquid substance Measures Methods Mus Nature Neurons Neurosciences Nucleus solitarius Nutrient Obesity Operative Surgical Procedures Optics Oral Pattern Pharmacology Phase Physiology Process Prosencephalon Rattus Regulation Reporting Satiation Signal Transduction Stimulus Stomach Stretching Structure System Taste Blindness Taste Perception Testing Time Viscera Visceral awake cell type conditioning experimental study feeding food consumption gastrointestinal in vivo mechanical signal neural neural circuit neuronal patterning noradrenergic optogenetics response sham feeding

项目摘要

Project Summary This proposal investigates the mechanisms that control satiation. This is a fundamental problem in physiology and also has relevance to obesity, because meal size is an important determinant of overall food intake. The caudal nucleus of the solitary tract (cNTS) contains key neural circuits for meal termination. These circuits integrate input from vagal afferents innervating the abdominal viscera as well as circulating hormonal and nutrient signals in order to trigger the termination of feeding. While cNTS cell types have long been studied using a variety of approaches, their natural activity patterns during behavior are almost completely unknown. Addressing this knowledge gap would reveal the nature of the key signals that regulate cNTS neurons during normal feeding, how these signals are integrated in specific cell types, and how they evolve during the course of a meal. In preliminary studies, we developed methods to record the activity of cNTS neurons in freely behaving mice and characterized their dynamics during feeding and in response to a variety of visceral stimuli. Here we propose to build on these findings to systematically dissect the signals that regulate cNTS satiety circuits in vivo. In Aims 1 and 2, we manipulate inputs at various stages of the GI tract and measure how this alters cNTS dynamics during feeding. In Aim 3, we use targeted optogenetic manipulations to boost or block elements of the natural activity patterns of these neurons and measure how this alters food intake and meal microstructure. Together, these experiments will reveal how the caudal brainstem dynamically integrates diverse inputs to enable the moment-by-moment control of feeding behavior.

项目总结

项目成果

期刊论文数量（24）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neural circuits underlying thirst and fluid homeostasis.

DOI：
10.1038/nrn.2017.71
发表时间：
2017-08
期刊：
Nature reviews. Neuroscience
影响因子：
0
作者：
Zimmerman CA;Leib DE;Knight ZA
通讯作者：
Knight ZA

Making sense of the sensory regulation of hunger neurons.

DOI：
10.1002/bies.201500167
发表时间：
2016-04
期刊：
BioEssays : news and reviews in molecular, cellular and developmental biology
影响因子：
0
作者：
Chen Y;Knight ZA
通讯作者：
Knight ZA

Layers of signals that regulate appetite.

DOI：
10.1016/j.conb.2020.03.007
发表时间：
2020-10
期刊：
Current opinion in neurobiology
影响因子：
5.7
作者：
Zimmerman CA;Knight ZA
通讯作者：
Knight ZA

A Spotlight on Appetite.

DOI：
10.1016/j.neuron.2018.01.050
发表时间：
2018-02-21
期刊：
Neuron
影响因子：
16.2
作者：
Beutler LR;Knight ZA
通讯作者：
Knight ZA

Identification of preoptic sleep neurons using retrograde labelling and gene profiling.

DOI：
10.1038/nature22350
发表时间：
2017-05-25
期刊：
Nature
影响因子：
64.8
作者：
Chung S;Weber F;Zhong P;Tan CL;Nguyen TN;Beier KT;Hörmann N;Chang WC;Zhang Z;Do JP;Yao S;Krashes MJ;Tasic B;Cetin A;Zeng H;Knight ZA;Luo L;Dan Y
通讯作者：
Dan Y