Neural Dynamics Underlying Feeding

喂养背后的神经动力学

• 批准号: 8946163
• 负责人: Zachary A. Knight
• 金额: $ 38.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-20 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8946163
• 关键词: Ablation; Afferent Pathways; Association Learning; Behavior; Biological Neural Networks; Brain; Brain region; Cells; Complex; Conditioned Stimulus; Cues; Data; Detection; Eating; Efferent Pathways; Elements; Energy Metabolism; Fasting; Fiber; Food; Food Energy; Glutamates; Hormones; Hypothalamic structure; Learning; Light; Maps; Mediating; Memory; Mus; N-Methyl-D-Aspartate Receptors; Neural Pathways; Neurons; Neurosciences; Nutritional; Obesity; Pathway interactions; Pattern; Photometry; Population; Population Control; Regulation; Role; Sensory; Smell Perception; Speed; Synapses; Testing; Time; Training; Vision; awake; cell type; classical conditioning; feeding; follow-up; food challenge; hedonic; in vivo; neural circuit; neuromechanism; public health relevance; relating to nervous system; research study; response

 DESCRIPTION (provided by applicant): A deeper understanding of the biologic origins of obesity will require mapping the neural networks that control feeding. Two key neural populations that control feeding are AgRP and POMC neurons in the hypothalamus. Despite extensive study of these cells over the past 20 years little is known about their natural dynamics in vivo. We have used fiber photometry to record the natural activity of AgRP and POMC neurons in awake behaving mice. Using this approach we have discovered that AgRP and POMC neurons are rapidly (seconds) and dramatically modulated by sensory cues associated with food. This regulation is cell-type-specific, is sensitive to food palatability and nutritional state, and occurs before any food is consumed. These data indicate the existence of an unanticipated neural pathway by which sensory detection of food generates rapid anticipatory changes in the activity of AgRP and POMC neurons. Importantly, this rapid regulation provides a mechanism for AgRP and POMC neurons to integrate sensory and hedonic cues with homeostatic information about nutritional state, suggesting a more complex role for these "first order" neurons than is currently appreciated. We propose here to delineate the neural mechanisms underlying the remarkable rapid regulation of these cells by food detection. We propose further to explore the downstream pathways to which these sensory cues are communicated in order to understand their role within a distributed feeding network.