Molecular Biophysics Training Grant

分子生物物理学培训补助金

• 批准号: 10616750
• 负责人: VENKATESH N MURTHY
• 金额: $ 63.66万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10616750
• 关键词: Biophysics; Grant; Molecular; Training

7. Project Summary/ Abstract The Molecular Biophysics Training Grant at Harvard University supports a predoctoral training program focused at the interface of physical and biological sciences. The goal of the program is to provide students with strong undergraduate backgrounds in quantitative sciences (especially physics and mathematics) with broad training in the biophysical, chemical and molecular concepts and techniques that are required to address outstanding problems in biology and biomedical sciences. The training program links a highly interactive group of 51 faculty members from four departments in Harvard's Faculty of Arts and Sciences, the School of Engineering and Applied Sciences, six departments at Harvard Medical School, and five affiliated hospitals. The training program offers a flexible curriculum drawn from courses offered at Harvard, Harvard Medical School and Massachusetts Institute of Technology (MIT), and research opportunities in a variety of disciplines relevant to molecular biophysics with particular strengths in the areas of structural biology, computational biology, quantitative cell biology, single molecule biophysics, neuroscience, and imaging. In addition to coursework and research activities, the training program sponsors seminars and guest lectures; a student-run research seminar series; a yearly offsite research retreat in the Fall that includes student and faculty research talks, a plenary lecture and a poster session featuring research of program students; a mini-symposium featuring talks by program faculty as well as a student poster session during the Biophysics Program recruitment weekend in the Spring term; and social events for all trainees. Over the past 29 years, this training program has helped foster a number of new initiatives in graduate training, and has been remarkably successful in promoting collaborative research among its faculty and interdisciplinary training for its students spanning all of Harvard and some of MIT. In this competing renewal, we request support for 16 training slots for students who are affiliated with Harvard's Biophysics Program or who are jointly affiliated with the Harvard Biophysics Program and Medical Engineering and Medical Physics Ph.D. program in the joint Harvard/ MIT Health Sciences and Technology initiative. Students will be preferentially funded in their first and second year of graduate studies.

7。项目摘要/摘要 哈佛大学的分子生物物理学培训补助金支持一项培训前培训计划 专注于物理和生物科学的界面。该计划的目的是为学生提供 具有广泛的定量科学（尤其是物理和数学）的强大本科背景 在生物物理，化学和分子概念和技术方面进行的培训 生物学和生物医学科学方面的杰出问题。培训计划链接了一个高度互动的小组 来自哈佛艺术与科学学院四个部门的51名教职员工 工程和应用科学，哈佛医学院的六个部门以及五家附属医院。 该培训计划提供了一门灵活的课程，该课程来自哈佛医疗的哈佛大学提供的课程 学校和马萨诸塞州理工学院（MIT）以及各种学科的研究机会 与结构生物学领域具有特殊优势的分子生物物理学相关，计算 生物学，定量细胞生物学，单分子生物物理学，神经科学和成像。此外 课程和研究活动，培训计划赞助研讨会和嘉宾讲座；学生经营 研究研讨会系列；秋季每年一次的异地研究务虚会，包括学生和教师研究 会谈，全体演讲和张贴者会议，其中包含课程学生的研究；一个迷你群岛 在生物物理学计划期间，由计划教师的演讲以及学生海报会议 春季学期的招聘周末；和所有学员的社交活动。在过去的29年中，这项培训 计划帮助培养了许多新的研究生培训计划，并且非常明显 成功地在其学生中促进其教师和跨学科培训的合作研究 跨越哈佛大学和一些麻省理工学院。 在这种竞争的续约中，我们要求为隶属于哈佛大学的学生提供16个培训插槽 生物物理学计划或联合隶属于哈佛生物物理学计划和医学工程 和医学物理博士联合哈佛/麻省理工学院健康科学与技术计划中的计划。 学生将在研究生的第一年和第二年获得优先资助。

项目成果

Engineered receptor binding domain immunogens elicit pan-sarbecovirus neutralizing antibodies outside the receptor binding motif.

• DOI: 10.1101/2020.12.07.415216
• 发表时间: 2021-06-29
• 期刊: bioRxiv : the preprint server for biology
• 作者: Hauser, Blake M;Sangesland, Maya;Schmidt, Aaron G
• 通讯作者: Schmidt, Aaron G

A chromosomal inversion contributes to divergence in multiple traits between deer mouse ecotypes.

• DOI: 10.1126/science.abg0718
• 发表时间: 2022-07-22
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Hager, Emily R.;Harringmeyer, Olivia S.;Wooldridge, T. Brock;Theingi, Shunn;Gable, Jacob T.;McFadden, Sade;Neugeboren, Beverly;Turner, Kyle M.;Jensen, Jeffrey D.;Hoekstra, Hopi E.
• 通讯作者: Hoekstra, Hopi E.

Transmission imaging for integrated PET-MR systems.

• DOI: 10.1088/0031-9155/61/15/5547
• 发表时间: 2016-08-07
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Bowen SL;Fuin N;Levine MA;Catana C
• 通讯作者: Catana C

Thermal stabilization of dihydrofolate reductase using monte carlo unfolding simulations and its functional consequences.

使用蒙特卡罗展开模拟的二氢叶酸还原酶的热稳定性及其功能结果

• DOI: 10.1371/journal.pcbi.1004207
• 发表时间: 2015-04
• 期刊: PLoS computational biology
• 影响因子: 4.3
• 作者: Tian J;Woodard JC;Whitney A;Shakhnovich EI
• 通讯作者: Shakhnovich EI

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions.

• DOI: 10.1038/nbt.3803
• 发表时间: 2017-04
• 期刊: Nature biotechnology
• 影响因子: 46.9
• 作者: Kim YB;Komor AC;Levy JM;Packer MS;Zhao KT;Liu DR
• 通讯作者: Liu DR