ICEMR-Mali : Multidisciplinary research for malaria control and prevention in West Africa

ICEMR-马里：西非疟疾控制和预防的多学科研究

• 批准号: 10590590
• 负责人: SEYDOU DOUMBIA
• 金额: $ 43.24万
• 依托单位: UNIV OF SCIENCES, TECH & TECH OF BAMAKO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-18 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10590590
• 关键词: 5 year old; Africa; Africa South of the Sahara; African; Anopheles Genus; Antimalarials; Area; Artemisinins; Beds; Behavior; Binding; Case Management; Cessation of life; Chemoprevention; Child; Climate; Combined Modality Therapy; Complex; Country; Development; Disease; Disease Outcome; Drug resistance; Dryness; Ecology; Effectiveness; Entomology; Environment; Epidemiology; Genetic; Genetic Variation; Genotype; Geographic Distribution; Goals; Guidelines; High Prevalence; Human; Immune response; Immunogenomics; Immunology; Incidence; Individual; Infection; Insecticide Resistance; Insecticides; Interdisciplinary Study; Intervention; Irrigation; Laboratory Study; Life; Link; Malaria; Mali; Measures; Niger; Outcome; Parasites; Pathogenesis; Pattern; Pharmacotherapy; Population; Pregnant Women; Prevention; Prospective Studies; Public Health; Reporting; Research; Research Personnel; Residual state; Rest; Rural; Sahara; Seasons; Site; Withdrawal; empowerment; epidemiology study; field study; improved; malaria infection; malaria transmission; neglect; resilience; response; scale up; tool; transmission process; vector; vector mosquito

SUMMARY Wide deployment of malaria control tools in the past decade has significantly contributed to substantial reduction of the incidence and deaths related to the disease in Sub-Sahara Africa.. Yet, the region continues to carry a disproportionately high share of the global malaria burden of malaria deaths. Moreover, incidence remains high but stable in some settings while rebounding in others after a long period of decrease associated with intensive deployment of malaria control tools. The Overall goal of this ICEMR is to understand the variable effectiveness of current malaria control interventions in different ecological settings of West Africa through research to understand interactions between the parasite (response to drug treatment, genotypes, gametocyte survival), human (immune response and host genetics) and the vector (ecology, behaviors, and response to insecticides) and regulating influences of the local environment and human behavior. This ICEMR encompasses 3 Projects with the goals summarized as follow: 1] Epidemiology Project (Project 1): The goal is to understand why different patterns of malaria epidemiology and endemicity are resilient to current control strategies at four sites in Mali, representing different eco-zones across West Africa, 2] Malaria immuno- genomics Project (Project 2): The goal of this project is to identify genetic variation in the malaria parasite and human host, and assess the impact of these differences on malaria transmission and effectiveness of malaria control measures in four sites of Mali , 3] Malaria vector and transmission field ecology project (Project 3): The project goal is to investigate important neglected aspects of malaria vector and transmission field ecology at four sites in Mali, representing three eco-zones across West Africa. These projects links the different aspects of malaria transmission and disease into a unified whole, adding the ability to distinguish the contributions of different malaria control interventions on parasite population and range of immune responses (Project 2, Immunopahtogenesis) and seasonal and geographical distribution of anopheline mosquitoes vectors (Project 3). Understanding the factors relating entomological and epidemiological patterns of transmission will provide more definitive guidelines for malaria control efforts in Mali and in West Africa.

总结

项目成果

Effect of seasonal malaria chemoprevention in children between 5 and 9 years old in Kita and Bafoulabe districts, Mali.

• DOI: 10.1016/j.parepi.2022.e00258
• 发表时间: 2022-08
• 期刊: PARASITE EPIDEMIOLOGY AND CONTROL
• 影响因子: 3.2
• 作者: Diawara, Sory Ibrahima;Konate, Drissa;Kayentao, Kassoum;Mihigo, Jules;Shaffer, Jeffrey G.;Sangare, Modibo;Ndabamenye, Protais;Swedberg, Eric;Garg, Lyndsey W.;Gamache, Nathalie;Keita, Bourama;Kamate, Beh;Ndaruhutse, Philbert;Kone, Diakalia;Sanogo, Vincent;Tounkara, Moctar;Diakite, Mahamadou;Doumbia, Seydou;Eckert, Erin
• 通讯作者: Eckert, Erin

Performance of pirimiphos-methyl based Indoor Residual Spraying on entomological parameters of malaria transmission in the pyrethroid resistance region of Koulikoro, Mali.

• DOI: 10.1016/j.actatropica.2020.105820
• 发表时间: 2021-04
• 期刊: Acta tropica
• 影响因子: 2.7
• 作者: Keïta M;Sogoba N;Traoré B;Kané F;Coulibaly B;Traoré SF;Doumbia S
• 通讯作者: Doumbia S

Impact of seasonal malaria chemoprevention in children aged 3 to 59 months in the Kangaba and Kolokani health districts between 2013 and 2015.

2013 年至 2015 年康加巴和科洛卡尼卫生区季节性疟疾化学预防对 3 至 59 个月儿童的影响。

• 发表时间: 2020
• 期刊: Revue malienne d'infectiologie et de microbiologie
• 作者: Oumar,AA;Ba,M;Diallo,D;Sanogo,M;Ousmane,FW;Diawara,SI;Guindo,JB;Malan,KI;Traore,SF;Diop,S
• 通讯作者: Diop,S

Effect of a fifth round of seasonal malaria chemoprevention in children aged 5-14 years in Dangassa, an area of long transmission in Mali.

• DOI: 10.1016/j.parepi.2022.e00283
• 发表时间: 2023-02
• 期刊: PARASITE EPIDEMIOLOGY AND CONTROL
• 影响因子: 3.2
• 作者: Konate, Drissa;Diawara, Sory I.;Sogoba, Nafomon;Shaffer, Jeff;Keita, Bourama;Cisse, Abdourhamane;Sanogo, Ibrahim;Dicko, Ilo;Guindo, Merepen dite Agnes;Balam, Saidou;Traore, Abdouramane;Kante, Salimata;Dembele, Assitan;Kasse, Fatoumata;Denou, Larissa;Diakite, Seidina A. S.;Traore, Karim;Thiam, Sidibe M'Baye;Sanogo, Vincent;Toure, Mahamoudou;Diarra, Ayouba;Agak, George W.;Doumbia, Seydou;Diakite, Mahamadou
• 通讯作者: Diakite, Mahamadou

Trends in malaria epidemiological factors following the implementation of current control strategies in Dangassa, Mali.

• DOI: 10.1186/s12936-022-04058-0
• 发表时间: 2022-02-23
• 期刊: Malaria journal
• 影响因子: 3
• 作者: Touré M;Keita M;Kané F;Sanogo D;Kanté S;Konaté D;Diarra A;Sogoba N;Coulibaly MB;Traoré SF;Alifrangis M;Diakité M;Shaffer JG;Krogstad DJ;Doumbia S
• 通讯作者: Doumbia S