A South Carolina ECHO Pregnancy Cohort
南卡罗来纳州 ECHO 妊娠队列
基本信息
- 批准号:10746617
- 负责人:
- 金额:$ 83.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAfricanAgeAirAnimalsArgentinaAsianBirthBlack PopulationsBlack raceCharacteristicsChemical ExposureChemicalsChildChild DevelopmentChildhoodConceptionsCountryCubaDeep SouthDeveloping CountriesDevelopmentDiscipline of obstetricsDiseaseDisease modelDisparityEgyptEnrollmentEnvironmental ExposureEnvironmental PollutantsEnvironmental Risk FactorEthnic OriginExposure toFetal DevelopmentFutureGeographyGoalsHealthHealthy People 2020Heart DiseasesHispanicHypertensionIndividualInfant MortalityInterventionJointsLatinxLebanonLifeLinkLive BirthMaternal MortalityMeasuresMedicaidMedicalMetabolicMexicoMothersNorth AmericaNot Hispanic or LatinoObesityObstetric DeliveryOccupationsOutcomePacific IslanderParticipantPerinatal ExposurePersonsPopulationPopulation HeterogeneityPregnancyPregnancy ComplicationsPregnancy OutcomePremature BirthProtocols documentationRaceRecording of previous eventsRecurrenceResearchRestRiskRisk FactorsRuralRural CommunityRural PopulationSiteSlaveSoilSourceSouth CarolinaStressStrokeStroke BeltTemperatureUnited States National Institutes of HealthUniversitiesVulnerable PopulationsWaterWater Supplyadult obesityburden of illnesscardiometabolic riskcardiovascular risk factorcohortdietaryearly life exposureenvironmental chemicalenvironmental stressorepidemiology studyethnic disparityethnic diversityethnic identityexperiencefetalgeographic disparityhealth disparityin uterointrauterine environmentmeetingsmortalityobesity in childrenobesity riskobesity treatmentoffspringpersonal care productspoor health outcomepregnancy disorderpregnantprenatalprenatal experienceprenatal exposureprepregnancy obesityprogramsracial discriminationracial disparityracial diversityracial health disparityrecruitresearch studysocialsocial vulnerabilitystroke incidencestudy populationurban area
项目摘要
ABSTRACT
Animal and epidemiological studies show that prenatal experiences (e.g., elevated environmental pollutants,
pregnancy complications, preterm birth, stress, racial discrimination) support the ‘developmental origins of
health and disease’ model in relating adverse maternal experiences to compromised fetal and child
development. Hypotheses suggest that the developmental window of plasticity for obesity programming
initiates in utero and extends through the first two years of life, underscoring the large impact that gestational
and early life exposures and corresponding targeted interventions may have on lifetime obesity risk. Current
obesity interventions may be ineffective because they target children or adults past the critical age when
developmental programming occurs. Because vulnerable populations are often the most impacted by exposure
to environmental stressors and poor health outcomes, it is critical that research studies include them.
Therefore, the overarching objective of our proposal is to increase the diversity of the ECHO Cohort. To
achieve this goal, we will recruit over 500 pregnant persons and their resulting offspring into ECHO from the
Medical University of South Carolina (MUSC) and implement the ECHO-wide protocol including specialized
components on Physical & Chemical exposures and child Obesity outcomes. Our proposed recruitment will
include 50% Black, 30% white/other and 20% Hispanic pregnant persons with half of the pregnant persons
(and their conceiving partners) also contributing to the preconception cohort. The racial and ethnic diversity of
the MUSC obstetrical population (i.e., 32% Black; 53% white; 12% Hispanic; and 2% Asian/Pacific Islander),
and large delivery population (i.e., over 3,000 annually) will facilitate meeting our recruitment goals. In 2022,
46% of deliveries at MUSC were covered by Medicaid and 5.5% were to Spanish speaking mothers, providing
further evidence of high social vulnerability in our study population. Because previous research has often been
conducted in urban areas, rural communities where many Blacks reside are often understudied. Hence, as a
rural state in the Deep South with poor birth outcomes and a socially vulnerable population, South Carolina’s
population is historically understudied and our contribution to ECHO will have a major impact. Our aims
pertaining to ECHO-wide analyses are (1) to determine the joint impact of prenatal exposure to chemical
mixtures and early gestational and life exposures (i.e., hypertensive disorders of pregnancy, preterm birth) on
child obesity and metabolic health; (2) to identify racial/ethnic disparities in prenatal chemical exposures and
their sources (dietary choices/opportunities, use of consumer goods and personal care products, occupation,
air/water) among participants in the ECHO cohort; and (3) to determine the association of mixtures of pre-
conceptual and peri-conceptual chemical exposures measured in both partners with hypertensive disorders of
pregnancy, preterm birth, and child obesity.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KELLY J HUNT其他文献
KELLY J HUNT的其他文献
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{{ truncateString('KELLY J HUNT', 18)}}的其他基金
Examining linkages between disrupted care and chronic disease outcomes during the COVID-19 pandemic: a VAMC level spatio-temporal analysis
检查 COVID-19 大流行期间中断的护理与慢性病结果之间的联系:VAMC 级别时空分析
- 批准号:
10641136 - 财政年份:2023
- 资助金额:
$ 83.32万 - 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结局的影响
- 批准号:
10598574 - 财政年份:2022
- 资助金额:
$ 83.32万 - 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes Div
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结果的影响 Div
- 批准号:
10732644 - 财政年份:2022
- 资助金额:
$ 83.32万 - 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结局的影响
- 批准号:
10467634 - 财政年份:2022
- 资助金额:
$ 83.32万 - 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
- 批准号:
10186523 - 财政年份:2018
- 资助金额:
$ 83.32万 - 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
- 批准号:
9904151 - 财政年份:2018
- 资助金额:
$ 83.32万 - 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
- 批准号:
9503218 - 财政年份:2018
- 资助金额:
$ 83.32万 - 项目类别:
Exposome Contributors to Child Health Originating from National Fetal Growth Study (ECCHO-NFGS)
源自国家胎儿生长研究 (ECCHO-NFGS) 的暴露组对儿童健康的贡献
- 批准号:
9355740 - 财政年份:2016
- 资助金额:
$ 83.32万 - 项目类别:
Longitudinal Assessment of LDL Immune Complexes and Type 1 Diabetes Complications
LDL 免疫复合物和 1 型糖尿病并发症的纵向评估
- 批准号:
8092481 - 财政年份:2010
- 资助金额:
$ 83.32万 - 项目类别:
Longitudinal Assessment of LDL Immune Complexes and Type 1 Diabetes Complications
LDL 免疫复合物和 1 型糖尿病并发症的纵向评估
- 批准号:
7949257 - 财政年份:2010
- 资助金额:
$ 83.32万 - 项目类别:
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