A South Carolina ECHO Pregnancy Cohort
南卡罗来纳州 ECHO 妊娠队列
基本信息
- 批准号:10746617
- 负责人:
- 金额:$ 83.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAfricanAgeAirAnimalsArgentinaAsianBirthBlack PopulationsBlack raceCharacteristicsChemical ExposureChemicalsChildChild DevelopmentChildhoodConceptionsCountryCubaDeep SouthDeveloping CountriesDevelopmentDiscipline of obstetricsDiseaseDisease modelDisparityEgyptEnrollmentEnvironmental ExposureEnvironmental PollutantsEnvironmental Risk FactorEthnic OriginExposure toFetal DevelopmentFutureGeographyGoalsHealthHealthy People 2020Heart DiseasesHispanicHypertensionIndividualInfant MortalityInterventionJointsLatinxLebanonLifeLinkLive BirthMaternal MortalityMeasuresMedicaidMedicalMetabolicMexicoMothersNorth AmericaNot Hispanic or LatinoObesityObstetric DeliveryOccupationsOutcomePacific IslanderParticipantPerinatal ExposurePersonsPopulationPopulation HeterogeneityPregnancyPregnancy ComplicationsPregnancy OutcomePremature BirthProtocols documentationRaceRecording of previous eventsRecurrenceResearchRestRiskRisk FactorsRuralRural CommunityRural PopulationSiteSlaveSoilSourceSouth CarolinaStressStrokeStroke BeltTemperatureUnited States National Institutes of HealthUniversitiesVulnerable PopulationsWaterWater Supplyadult obesityburden of illnesscardiometabolic riskcardiovascular risk factorcohortdietaryearly life exposureenvironmental chemicalenvironmental stressorepidemiology studyethnic disparityethnic diversityethnic identityexperiencefetalgeographic disparityhealth disparityin uterointrauterine environmentmeetingsmortalityobesity in childrenobesity riskobesity treatmentoffspringpersonal care productspoor health outcomepregnancy disorderpregnantprenatalprenatal experienceprenatal exposureprepregnancy obesityprogramsracial discriminationracial disparityracial diversityracial health disparityrecruitresearch studysocialsocial vulnerabilitystroke incidencestudy populationurban area
项目摘要
ABSTRACT
Animal and epidemiological studies show that prenatal experiences (e.g., elevated environmental pollutants,
pregnancy complications, preterm birth, stress, racial discrimination) support the ‘developmental origins of
health and disease’ model in relating adverse maternal experiences to compromised fetal and child
development. Hypotheses suggest that the developmental window of plasticity for obesity programming
initiates in utero and extends through the first two years of life, underscoring the large impact that gestational
and early life exposures and corresponding targeted interventions may have on lifetime obesity risk. Current
obesity interventions may be ineffective because they target children or adults past the critical age when
developmental programming occurs. Because vulnerable populations are often the most impacted by exposure
to environmental stressors and poor health outcomes, it is critical that research studies include them.
Therefore, the overarching objective of our proposal is to increase the diversity of the ECHO Cohort. To
achieve this goal, we will recruit over 500 pregnant persons and their resulting offspring into ECHO from the
Medical University of South Carolina (MUSC) and implement the ECHO-wide protocol including specialized
components on Physical & Chemical exposures and child Obesity outcomes. Our proposed recruitment will
include 50% Black, 30% white/other and 20% Hispanic pregnant persons with half of the pregnant persons
(and their conceiving partners) also contributing to the preconception cohort. The racial and ethnic diversity of
the MUSC obstetrical population (i.e., 32% Black; 53% white; 12% Hispanic; and 2% Asian/Pacific Islander),
and large delivery population (i.e., over 3,000 annually) will facilitate meeting our recruitment goals. In 2022,
46% of deliveries at MUSC were covered by Medicaid and 5.5% were to Spanish speaking mothers, providing
further evidence of high social vulnerability in our study population. Because previous research has often been
conducted in urban areas, rural communities where many Blacks reside are often understudied. Hence, as a
rural state in the Deep South with poor birth outcomes and a socially vulnerable population, South Carolina’s
population is historically understudied and our contribution to ECHO will have a major impact. Our aims
pertaining to ECHO-wide analyses are (1) to determine the joint impact of prenatal exposure to chemical
mixtures and early gestational and life exposures (i.e., hypertensive disorders of pregnancy, preterm birth) on
child obesity and metabolic health; (2) to identify racial/ethnic disparities in prenatal chemical exposures and
their sources (dietary choices/opportunities, use of consumer goods and personal care products, occupation,
air/water) among participants in the ECHO cohort; and (3) to determine the association of mixtures of pre-
conceptual and peri-conceptual chemical exposures measured in both partners with hypertensive disorders of
pregnancy, preterm birth, and child obesity.
抽象的
动物和流行病学研究表明,产前经历(例如环境污染物升高、
妊娠并发症、早产、压力、种族歧视)支持“发育起源”
将不良孕产妇经历与受损胎儿和儿童联系起来的健康与疾病模型
发展。假设表明肥胖编程的可塑性发育窗口
它在子宫内开始并持续到生命的头两年,强调了妊娠期的巨大影响
生命早期的暴露和相应的有针对性的干预措施可能会影响终生肥胖风险。当前的
肥胖干预措施可能无效,因为它们针对的是超过关键年龄的儿童或成人
发生发展性编程。因为弱势群体往往受暴露影响最大
对于环境压力因素和不良健康结果,研究将其纳入其中至关重要。
因此,我们提案的首要目标是增加 ECHO 队列的多样性。到
为了实现这一目标,我们将从 ECHO 招募超过 500 名孕妇及其后代
南卡罗来纳医科大学 (MUSC) 并实施 ECHO 范围内的协议,包括专门的
物理和化学暴露以及儿童肥胖结果的组成部分。我们提议的招聘将
包括 50% 黑人、30% 白人/其他人和 20% 西班牙裔孕妇,其中一半孕妇
(及其怀孕伴侣)也为孕前队列做出了贡献。种族和民族的多样性
MUSC 产科人口(即 32% 黑人;53% 白人;12% 西班牙裔;2% 亚洲/太平洋岛民),
大量的配送人口(即每年超过 3,000 人)将有助于实现我们的招聘目标。 2022年,
MUSC 46% 的分娩由医疗补助承保,其中 5.5% 的分娩对象是讲西班牙语的母亲,这提供了
进一步证明我们的研究人群具有高度的社会脆弱性。因为之前的研究常常是
尽管这些研究在城市地区进行,但对许多黑人居住的农村社区的研究往往不够充分。因此,作为一个
南卡罗来纳州是南部腹地的一个农村州,出生结果不佳,社会弱势群体
历史上对人口的研究不足,我们对 ECHO 的贡献将产生重大影响。我们的目标
与 ECHO 范围内的分析相关的内容包括 (1) 确定产前接触化学品的联合影响
混合物以及妊娠早期和生活暴露(即妊娠期高血压疾病、早产)
儿童肥胖与代谢健康; (2) 确定产前化学品暴露方面的种族/民族差异;
它们的来源(饮食选择/机会、消费品和个人护理产品的使用、职业、
ECHO 队列参与者中的空气/水); (3) 确定预混合物的关联性
在患有高血压疾病的伴侣中测量概念性和围概念性化学暴露
怀孕、早产和儿童肥胖。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
KELLY J HUNT其他文献
KELLY J HUNT的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('KELLY J HUNT', 18)}}的其他基金
Examining linkages between disrupted care and chronic disease outcomes during the COVID-19 pandemic: a VAMC level spatio-temporal analysis
检查 COVID-19 大流行期间中断的护理与慢性病结果之间的联系:VAMC 级别时空分析
- 批准号:
10641136 - 财政年份:2023
- 资助金额:
$ 83.32万 - 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结局的影响
- 批准号:
10598574 - 财政年份:2022
- 资助金额:
$ 83.32万 - 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes Div
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结果的影响 Div
- 批准号:
10732644 - 财政年份:2022
- 资助金额:
$ 83.32万 - 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结局的影响
- 批准号:
10467634 - 财政年份:2022
- 资助金额:
$ 83.32万 - 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
- 批准号:
10186523 - 财政年份:2018
- 资助金额:
$ 83.32万 - 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
- 批准号:
9904151 - 财政年份:2018
- 资助金额:
$ 83.32万 - 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
- 批准号:
9503218 - 财政年份:2018
- 资助金额:
$ 83.32万 - 项目类别:
Exposome Contributors to Child Health Originating from National Fetal Growth Study (ECCHO-NFGS)
源自国家胎儿生长研究 (ECCHO-NFGS) 的暴露组对儿童健康的贡献
- 批准号:
9355740 - 财政年份:2016
- 资助金额:
$ 83.32万 - 项目类别:
Longitudinal Assessment of LDL Immune Complexes and Type 1 Diabetes Complications
LDL 免疫复合物和 1 型糖尿病并发症的纵向评估
- 批准号:
8092481 - 财政年份:2010
- 资助金额:
$ 83.32万 - 项目类别:
Longitudinal Assessment of LDL Immune Complexes and Type 1 Diabetes Complications
LDL 免疫复合物和 1 型糖尿病并发症的纵向评估
- 批准号:
7949257 - 财政年份:2010
- 资助金额:
$ 83.32万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 83.32万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 83.32万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 83.32万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 83.32万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 83.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 83.32万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 83.32万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 83.32万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 83.32万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 83.32万 - 项目类别:
Studentship














{{item.name}}会员




