A South Carolina ECHO Pregnancy Cohort
南卡罗来纳州 ECHO 妊娠队列
基本信息
- 批准号:10746617
- 负责人:
- 金额:$ 83.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAfricanAgeAirAnimalsArgentinaAsianBirthBlack PopulationsBlack raceCharacteristicsChemical ExposureChemicalsChildChild DevelopmentChildhoodConceptionsCountryCubaDeep SouthDeveloping CountriesDevelopmentDiscipline of obstetricsDiseaseDisease modelDisparityEgyptEnrollmentEnvironmental ExposureEnvironmental PollutantsEnvironmental Risk FactorEthnic OriginExposure toFetal DevelopmentFutureGeographyGoalsHealthHealthy People 2020Heart DiseasesHispanicHypertensionIndividualInfant MortalityInterventionJointsLatinxLebanonLifeLinkLive BirthMaternal MortalityMeasuresMedicaidMedicalMetabolicMexicoMothersNorth AmericaNot Hispanic or LatinoObesityObstetric DeliveryOccupationsOutcomePacific IslanderParticipantPerinatal ExposurePersonsPopulationPopulation HeterogeneityPregnancyPregnancy ComplicationsPregnancy OutcomePremature BirthProtocols documentationRaceRecording of previous eventsRecurrenceResearchRestRiskRisk FactorsRuralRural CommunityRural PopulationSiteSlaveSoilSourceSouth CarolinaStressStrokeStroke BeltTemperatureUnited States National Institutes of HealthUniversitiesVulnerable PopulationsWaterWater Supplyadult obesityburden of illnesscardiometabolic riskcardiovascular risk factorcohortdietaryearly life exposureenvironmental chemicalenvironmental stressorepidemiology studyethnic disparityethnic diversityethnic identityexperiencefetalgeographic disparityhealth disparityin uterointrauterine environmentmeetingsmortalityobesity in childrenobesity riskobesity treatmentoffspringpersonal care productspoor health outcomepregnancy disorderpregnantprenatalprenatal experienceprenatal exposureprepregnancy obesityprogramsracial discriminationracial disparityracial diversityracial health disparityrecruitresearch studysocialsocial vulnerabilitystroke incidencestudy populationurban area
项目摘要
ABSTRACT
Animal and epidemiological studies show that prenatal experiences (e.g., elevated environmental pollutants,
pregnancy complications, preterm birth, stress, racial discrimination) support the ‘developmental origins of
health and disease’ model in relating adverse maternal experiences to compromised fetal and child
development. Hypotheses suggest that the developmental window of plasticity for obesity programming
initiates in utero and extends through the first two years of life, underscoring the large impact that gestational
and early life exposures and corresponding targeted interventions may have on lifetime obesity risk. Current
obesity interventions may be ineffective because they target children or adults past the critical age when
developmental programming occurs. Because vulnerable populations are often the most impacted by exposure
to environmental stressors and poor health outcomes, it is critical that research studies include them.
Therefore, the overarching objective of our proposal is to increase the diversity of the ECHO Cohort. To
achieve this goal, we will recruit over 500 pregnant persons and their resulting offspring into ECHO from the
Medical University of South Carolina (MUSC) and implement the ECHO-wide protocol including specialized
components on Physical & Chemical exposures and child Obesity outcomes. Our proposed recruitment will
include 50% Black, 30% white/other and 20% Hispanic pregnant persons with half of the pregnant persons
(and their conceiving partners) also contributing to the preconception cohort. The racial and ethnic diversity of
the MUSC obstetrical population (i.e., 32% Black; 53% white; 12% Hispanic; and 2% Asian/Pacific Islander),
and large delivery population (i.e., over 3,000 annually) will facilitate meeting our recruitment goals. In 2022,
46% of deliveries at MUSC were covered by Medicaid and 5.5% were to Spanish speaking mothers, providing
further evidence of high social vulnerability in our study population. Because previous research has often been
conducted in urban areas, rural communities where many Blacks reside are often understudied. Hence, as a
rural state in the Deep South with poor birth outcomes and a socially vulnerable population, South Carolina’s
population is historically understudied and our contribution to ECHO will have a major impact. Our aims
pertaining to ECHO-wide analyses are (1) to determine the joint impact of prenatal exposure to chemical
mixtures and early gestational and life exposures (i.e., hypertensive disorders of pregnancy, preterm birth) on
child obesity and metabolic health; (2) to identify racial/ethnic disparities in prenatal chemical exposures and
their sources (dietary choices/opportunities, use of consumer goods and personal care products, occupation,
air/water) among participants in the ECHO cohort; and (3) to determine the association of mixtures of pre-
conceptual and peri-conceptual chemical exposures measured in both partners with hypertensive disorders of
pregnancy, preterm birth, and child obesity.
摘要
动物和流行病学研究表明,产前经历(例如,环境污染物增加,
怀孕并发症、早产、压力、种族歧视)支持“发育起源",
健康和疾病模型在不良母亲经历与胎儿和儿童受损关系中的应用
发展假设表明,发育窗口的可塑性肥胖编程
在子宫内开始,并延伸到生命的头两年,强调了妊娠的巨大影响,
早期生活暴露和相应的有针对性的干预措施可能对终身肥胖风险有影响。电流
肥胖干预可能是无效的,因为他们针对的是儿童或成年人,
发展性编程发生。因为弱势群体往往是受辐射影响最大的群体,
对于环境压力因素和不良健康结果,至关重要的是,研究将其包括在内。
因此,我们提案的总体目标是增加ECHO队列的多样性。到
为了实现这一目标,我们将从ECHO招募500多名孕妇及其后代,
南卡罗来纳州医科大学(MUSC),并实施ECHO范围内的协议,包括专门的
物理和化学暴露和儿童肥胖结果的组成部分。我们的招聘计划将
包括50%的黑人、30%的白色/其他和20%的西班牙裔孕妇,其中一半孕妇
(and他们的怀孕伴侣)也有助于孕前队列。种族和民族多样性
MUSC产科人口(即,32%黑人; 53%白色; 12%西班牙裔; 2%亚洲/太平洋岛民),
和大的递送群体(即,每年超过3,000人)将有助于实现我们的招聘目标。2022年,
MUSC的46%的分娩由医疗补助覆盖,5.5%是讲西班牙语的母亲,
进一步证明了我们研究人群中的高社会脆弱性。因为以前的研究往往是
在城市地区进行,许多黑人居住的农村社区往往没有得到充分研究。因此,作为
南卡罗来纳州是美国南部腹地的一个农村州,人口出生率低,社会弱势群体多,
人口问题历来研究不足,我们对欧共体人道处的贡献将产生重大影响。我们的目标
与ECHO范围内的分析有关的是(1)确定产前接触化学品的联合影响
混合物和早期妊娠期和生命期暴露(即,妊娠期高血压疾病、早产)
儿童肥胖和代谢健康;(2)确定产前化学品暴露方面的种族/民族差异,
他们的来源(饮食选择/机会,消费品和个人护理产品的使用,职业,
空气/水);和(3)确定前-
在患有高血压疾病的伴侣中测量的概念和围概念化学暴露,
怀孕、早产和儿童肥胖。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KELLY J HUNT其他文献
KELLY J HUNT的其他文献
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{{ truncateString('KELLY J HUNT', 18)}}的其他基金
Examining linkages between disrupted care and chronic disease outcomes during the COVID-19 pandemic: a VAMC level spatio-temporal analysis
检查 COVID-19 大流行期间中断的护理与慢性病结果之间的联系:VAMC 级别时空分析
- 批准号:
10641136 - 财政年份:2023
- 资助金额:
$ 83.32万 - 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结局的影响
- 批准号:
10598574 - 财政年份:2022
- 资助金额:
$ 83.32万 - 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes Div
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结果的影响 Div
- 批准号:
10732644 - 财政年份:2022
- 资助金额:
$ 83.32万 - 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结局的影响
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10467634 - 财政年份:2022
- 资助金额:
$ 83.32万 - 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
- 批准号:
10186523 - 财政年份:2018
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$ 83.32万 - 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
- 批准号:
9904151 - 财政年份:2018
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Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
- 批准号:
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源自国家胎儿生长研究 (ECCHO-NFGS) 的暴露组对儿童健康的贡献
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Longitudinal Assessment of LDL Immune Complexes and Type 1 Diabetes Complications
LDL 免疫复合物和 1 型糖尿病并发症的纵向评估
- 批准号:
7949257 - 财政年份:2010
- 资助金额:
$ 83.32万 - 项目类别:
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