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A South Carolina ECHO Pregnancy Cohort

南卡罗来纳州 ECHO 妊娠队列

基本信息

批准号：
10746617
负责人：
KELLY J HUNT
金额：
$ 83.32万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10746617
关键词：
Adult Affect African Age Air Animals Argentina Asian Birth Black Populations Black race Characteristics Chemical Exposure Chemicals Child Child Development Childhood Conceptions Country Cuba Deep South Developing Countries Development Discipline of obstetrics Disease Disease model Disparity Egypt Enrollment Environmental Exposure Environmental Pollutants Environmental Risk Factor Ethnic Origin Exposure to Fetal Development Future Geography Goals Health Healthy People 2020 Heart Diseases Hispanic Hypertension Individual Infant Mortality Intervention Joints Latinx Lebanon Life Link Live Birth Maternal Mortality Measures Medicaid Medical Metabolic Mexico Mothers North America Not Hispanic or Latino Obesity Obstetric Delivery Occupations Outcome Pacific Islander Participant Perinatal Exposure Persons Population Population Heterogeneity Pregnancy Pregnancy Complications Pregnancy Outcome Premature Birth Protocols documentation Race Recording of previous events Recurrence Research Rest Risk Risk Factors Rural Rural Community Rural Population Site Slave Soil Source South Carolina Stress Stroke Stroke Belt Temperature United States National Institutes of Health Universities Vulnerable Populations Water Water Supply adult obesity burden of illness cardiometabolic risk cardiovascular risk factor cohort dietary early life exposure environmental chemical environmental stressor epidemiology study ethnic disparity ethnic diversity ethnic identity experience fetal geographic disparity health disparity in utero intrauterine environment meetings mortality obesity in children obesity risk obesity treatment offspring personal care products poor health outcome pregnancy disorder pregnant prenatal prenatal experience prenatal exposure prepregnancy obesity programs racial discrimination racial disparity racial diversity racial health disparity recruit research study social social vulnerability stroke incidence study population urban area

项目摘要

ABSTRACT Animal and epidemiological studies show that prenatal experiences (e.g., elevated environmental pollutants, pregnancy complications, preterm birth, stress, racial discrimination) support the ‘developmental origins of health and disease’ model in relating adverse maternal experiences to compromised fetal and child development. Hypotheses suggest that the developmental window of plasticity for obesity programming initiates in utero and extends through the first two years of life, underscoring the large impact that gestational and early life exposures and corresponding targeted interventions may have on lifetime obesity risk. Current obesity interventions may be ineffective because they target children or adults past the critical age when developmental programming occurs. Because vulnerable populations are often the most impacted by exposure to environmental stressors and poor health outcomes, it is critical that research studies include them. Therefore, the overarching objective of our proposal is to increase the diversity of the ECHO Cohort. To achieve this goal, we will recruit over 500 pregnant persons and their resulting offspring into ECHO from the Medical University of South Carolina (MUSC) and implement the ECHO-wide protocol including specialized components on Physical & Chemical exposures and child Obesity outcomes. Our proposed recruitment will include 50% Black, 30% white/other and 20% Hispanic pregnant persons with half of the pregnant persons (and their conceiving partners) also contributing to the preconception cohort. The racial and ethnic diversity of the MUSC obstetrical population (i.e., 32% Black; 53% white; 12% Hispanic; and 2% Asian/Pacific Islander), and large delivery population (i.e., over 3,000 annually) will facilitate meeting our recruitment goals. In 2022, 46% of deliveries at MUSC were covered by Medicaid and 5.5% were to Spanish speaking mothers, providing further evidence of high social vulnerability in our study population. Because previous research has often been conducted in urban areas, rural communities where many Blacks reside are often understudied. Hence, as a rural state in the Deep South with poor birth outcomes and a socially vulnerable population, South Carolina’s population is historically understudied and our contribution to ECHO will have a major impact. Our aims pertaining to ECHO-wide analyses are (1) to determine the joint impact of prenatal exposure to chemical mixtures and early gestational and life exposures (i.e., hypertensive disorders of pregnancy, preterm birth) on child obesity and metabolic health; (2) to identify racial/ethnic disparities in prenatal chemical exposures and their sources (dietary choices/opportunities, use of consumer goods and personal care products, occupation, air/water) among participants in the ECHO cohort; and (3) to determine the association of mixtures of pre- conceptual and peri-conceptual chemical exposures measured in both partners with hypertensive disorders of pregnancy, preterm birth, and child obesity.

摘要