Predoctoral Training in the Pharmacological Sciences

药理学培训计划(PSTP)的使命是培养杰出的科学家 药理科学，使他们能够过渡到美国的任何不同的职业机会。 生物医学研究企业。一支高生产率和资金雄厚的教师队伍提供了多样化的研究领域 对于学员来说，这是建立在我们在受体和信号转导、癌症和蛋白质方面的传统优势的基础上的 激酶和神经药理学，以及化学生物学、纳米技术、基因组学和 蛋白质组学、干细胞、RNA生物学、生物信息学和系统生物学。学生申请生物和 生物医学计划(BBSP)，14个学位授予的招生门户/第一年计划 系，一个伞式计划，监督招收和培训大学一年级研究生 生物医学科学。BBSP每年平均招收75-90名学生，增加到100名。 学生们定于2019年入学。相当一部分(20%-25%)的入学学生在 生物医学科学。学生们进行三次研究轮换，参加一年级的必修课程和另一门课程 选择课程，并在第一年结束时选择一位论文导师和一个授予学位的博士学位 为他们的论文研究制定了计划。参加PSTP的学生从46名核心教员中选择他们的论文 研究。一个非常强大的医学科学家培训计划(MSTP)也每年招收约10名学生，0-2 他们每年都会加入PSTP。 PSTP围绕一套相辅相成的培训工具进行设计，包括正式的讲授课程， 以科学交流技能为重点的研讨会课程，沉浸式拨款撰写课程，以及原创课程 博士研究。我们的理由是，通过结合这些培训方法，我们为学员做好了以下准备 未来的成功。药理学和生理学入门和高级课程，以及选修专业 课程是第一年和第二年的必修课。一门严谨而密集的助学金写作课程 识别重要的、创新的和易于处理的研究问题和假设并制定 检验这些假说的一套强有力的具体目标。演示课程和学生研讨会系列 为学生提供许多机会来磨练他们的研究陈述技能并在公共场合获得信心 我是。通过对生物统计学、生物计算和配体的高度重视，发展了定量技能。 受体结合理论与分析。所有培训机会都强调严谨性和可重复性。 为所有学生起草个人发展计划，并用于确定量化技能课程 与学生的研究项目密切相关。一个健全的咨询系统监督着多年来的论文研究 学生们。教师依靠循证指导实践来最好地帮助学生实现共同的目标。基座 在前几年，我们预计将有9-11名符合培训补助金资格的新学生进入PSTP 每年都会有计划。学生将被任命为培训补助金的最长期限为两年，在 他们研究生院的第二年和第三年。所有PSTP在过去五年的平均完成时间 学生，包括来自代表性不足群体的实习生，是5.5岁，这些学生平均有4年 出版物，其中不到两本是第一作者出版物。当前PSTP的23% 受训人员来自代表性不足的群体，我们目前的三名UR受训人员获得了 HHMI/Gilliam高级研究奖学金。我们的总体目标是通过以下方式培养一批多样化的未来科学家 让他们具备批判性思维、计算和沟通技能，并接触到无数 职业机会需要在他们选择的科学职业中获得一个职位。

The mission of the Pharmacological Sciences Training Program (PSTP) is to train outstanding scientists in the pharmacological sciences, enabling them to transition to any of the varied career opportunities in the U.S. biomedical research enterprise. A highly productive and well-funded faculty provide a diversity of research areas for trainees that builds on our traditional strengths in receptors and signal transduction, cancer and protein kinases, and neuropharmacology with emerging areas in chemical biology, nanotechnology, genomics and proteomics, stem cells, RNA biology, bioinformatics and systems biology. Students apply to the Biological and Biomedical Sciences Program (BBSP), an admissions portal/first year program for 14 degree-granting departments, an umbrella program that oversees recruitment and training of first-year graduate students in the biomedical sciences. The BBSP admits between on average 75-90 students per year, with an increase to 100 students slated for 2019. A significant portion (20-25%) of matriculating students are underrepresented in the biomedical sciences. Students carry out three research rotations, take a required first year course and another course of their choosing, and, at the end of their first year, select a thesis mentor and a degree-granting PhD program for their thesis research. Students joining the PSTP choose from 46-core faculty for their dissertation research. A very strong Medical Scientist Training Program (MSTP) also brings in ~10 students per year, 0-2 of which join the PSTP per year. The PSTP is designed around a complementary set of training tools, including formal lecture-based courses, seminar courses focusing on scientific communication skills, an immersive grant-writing course, and original doctoral research. Our rationale is that by combining these training approaches, we prepare our trainees for future success. Introductory and advanced courses in pharmacology and physiology, and elective specialized courses are required during the first and second years. A rigorous and intensive grant-writing course develops skills for identifying an important, innovative and tractable research question and hypotheses and formulating a strong set of Specific Aims that test these hypotheses. Presentation courses and a student seminar series provide students with many opportunities to hone their research presentation skills and gain confidence in public speaking. Quantitative skills are developed through strong emphasis on biostatistics, biocomputation, and ligand- receptor binding theory and analysis. Rigor and reproducibility are emphasized across all training opportunities. Individual Development Plans are drafted for all students, and also are used to identify quantitative skills classes germane to the students’ research projects. A robust advisory system oversees the thesis research years of students. Faculty rely on evidence-based mentoring practices to best help students achieve shared goals. Based on previous years, we anticipate that we will have 9-11 new, training grant-eligible students entering the PSTP program each year. Students will be appointed to the training grant for a maximum duration of two years, during their second and third year of graduate school. The average time-to-degree over the last five years for all PSTP students, including trainees from underrepresented groups, is 5.5 years, and these students had on average 4 publications, a little less than two of which were first-author publications. Twenty-three percent of current PSTP trainees are from underrepresented groups, and three of our current UR trainees were awarded the prestigious HHMI/Gilliam Fellowship for Advanced Study. Our overall goal is to train a diverse cohort of future scientists by equipping them with critical-thinking, computational, and communication skills and providing exposure to myriad career opportunities needed to obtain a position in a scientific career of their choosing.