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Predoctoral Training in the Pharmacological Sciences

药理学博士前培训

基本信息

批准号：
10612421
负责人：
Joseph Mauro Calabrese
金额：
$ 53.05万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612421
关键词：
Science Training pharmacologic pre-doctoral

项目摘要

The mission of the Pharmacological Sciences Training Program (PSTP) is to train outstanding scientists in the pharmacological sciences, enabling them to transition to any of the varied career opportunities in the U.S. biomedical research enterprise. A highly productive and well-funded faculty provide a diversity of research areas for trainees that builds on our traditional strengths in receptors and signal transduction, cancer and protein kinases, and neuropharmacology with emerging areas in chemical biology, nanotechnology, genomics and proteomics, stem cells, RNA biology, bioinformatics and systems biology. Students apply to the Biological and Biomedical Sciences Program (BBSP), an admissions portal/first year program for 14 degree-granting departments, an umbrella program that oversees recruitment and training of first-year graduate students in the biomedical sciences. The BBSP admits between on average 75-90 students per year, with an increase to 100 students slated for 2019. A significant portion (20-25%) of matriculating students are underrepresented in the biomedical sciences. Students carry out three research rotations, take a required first year course and another course of their choosing, and, at the end of their first year, select a thesis mentor and a degree-granting PhD program for their thesis research. Students joining the PSTP choose from 46-core faculty for their dissertation research. A very strong Medical Scientist Training Program (MSTP) also brings in ~10 students per year, 0-2 of which join the PSTP per year. The PSTP is designed around a complementary set of training tools, including formal lecture-based courses, seminar courses focusing on scientific communication skills, an immersive grant-writing course, and original doctoral research. Our rationale is that by combining these training approaches, we prepare our trainees for future success. Introductory and advanced courses in pharmacology and physiology, and elective specialized courses are required during the first and second years. A rigorous and intensive grant-writing course develops skills for identifying an important, innovative and tractable research question and hypotheses and formulating a strong set of Specific Aims that test these hypotheses. Presentation courses and a student seminar series provide students with many opportunities to hone their research presentation skills and gain confidence in public speaking. Quantitative skills are developed through strong emphasis on biostatistics, biocomputation, and ligand- receptor binding theory and analysis. Rigor and reproducibility are emphasized across all training opportunities. Individual Development Plans are drafted for all students, and also are used to identify quantitative skills classes germane to the students’ research projects. A robust advisory system oversees the thesis research years of students. Faculty rely on evidence-based mentoring practices to best help students achieve shared goals. Based on previous years, we anticipate that we will have 9-11 new, training grant-eligible students entering the PSTP program each year. Students will be appointed to the training grant for a maximum duration of two years, during their second and third year of graduate school. The average time-to-degree over the last five years for all PSTP students, including trainees from underrepresented groups, is 5.5 years, and these students had on average 4 publications, a little less than two of which were first-author publications. Twenty-three percent of current PSTP trainees are from underrepresented groups, and three of our current UR trainees were awarded the prestigious HHMI/Gilliam Fellowship for Advanced Study. Our overall goal is to train a diverse cohort of future scientists by equipping them with critical-thinking, computational, and communication skills and providing exposure to myriad career opportunities needed to obtain a position in a scientific career of their choosing.

药理学科学培训计划（PSTP）的使命是培养杰出的科学家，药理学，使他们能够过渡到美国的任何不同的职业机会。生物医学研究企业。一个高效和资金充足的教师提供了研究领域的多样性我们在受体和信号转导、癌症和蛋白质方面的传统优势激酶和神经药理学与新兴领域的化学生物学，纳米技术，基因组学和蛋白质组学、干细胞、RNA生物学、生物信息学和系统生物学。学生申请生物和生物医学科学计划（BBSP），一个招生门户网站/第一年的计划，为14个学位授予部门，一个伞计划，监督招聘和培训一年级研究生在生物医学科学BBSP每年平均招收75-90名学生，每年增加到100名 2019年的学生。很大一部分（20-25%）被录取的学生在学校的代表性不足。生物医学科学学生进行三次研究轮换，参加第一年的必修课程，他们选择的课程，并在第一年结束时，选择论文导师和授予学位的博士学位他们的论文研究计划。加入PSTP的学生从46个核心教师中选择论文 research.一个非常强大的医学科学家培训计划（MSTP）也带来了〜 10名学生每年，0-2 每年加入PSTP。 PSTP是围绕一套互补的培训工具设计的，包括正式的基于讲座的课程，研讨会课程侧重于科学沟通技巧，沉浸式赠款写作课程，以及原创博士研究。我们的理由是，通过结合这些培训方法，我们为学员做好准备，未来的成功药理学和生理学的入门和高级课程，以及选修专业课程在第一和第二年期间，课程是必修的。一个严格和密集的赠款写作课程开发确定一个重要的，创新的和易处理的研究问题和假设，并制定一个测试这些假设的一组强有力的具体目标。介绍课程和学生研讨会系列为学生提供许多机会来磨练他们的研究演讲技巧，并在公众场合获得信心说话定量技能是通过对生物统计学，生物计算和配体的高度重视发展起来的。受体结合理论与分析所有培训机会都强调严格性和可重复性。为所有学生起草个人发展计划，并用于确定定量技能课程与学生的研究项目密切相关。一个强大的咨询系统监督论文研究年学生教师依靠基于证据的指导实践，以最好地帮助学生实现共同的目标。基于与前几年相比，我们预计将有9-11名符合培训补助金条件的新学生进入PSTP 每年的节目。学生将被任命领取培训补助金，最长期限为两年，研究生院的第二年和第三年。所有PSTP在过去五年中获得学位的平均时间学生，包括来自代表性不足群体的受训人员，平均为5.5年，这些学生平均有4年出版物，其中不到两个是第一作者出版物。当前PSTP的23% 学员来自代表性不足的群体，我们目前的UR学员中有三人被授予享有盛誉的 HHMI/Gilliam高级研究奖学金。我们的总体目标是通过以下方式培养多元化的未来科学家群体使他们具备批判性思维、计算和沟通技能，职业机会，以获得他们选择的科学职业的位置。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Predicting in vivo activity of combination therapies from in vitro drug pairs in diverse environments.

DOI：
10.1016/j.xcrm.2022.100745
发表时间：
2022-09-20
期刊：
CELL REPORTS MEDICINE
影响因子：
14.3
作者：
Patterson, Sarah;Palmer, Adam
通讯作者：
Palmer, Adam

All Hands on Deck: We Need Multiple Approaches To Uncover the Neuroscience behind the Opioid Overdose Crisis.

DOI：
10.1021/acschemneuro.2c00818
发表时间：
2023-06-07
期刊：
ACS CHEMICAL NEUROSCIENCE
影响因子：
5
作者：
Bedard, Madigan L.;Nowlan, Alexandra C.;Campo, Zoe Martin del;Miller, Colin;Desgupta, Nabarun;McElligott, Zoe A.
通讯作者：
McElligott, Zoe A.

Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation.

复杂的促成复合体/循环体的复杂调节机制及其在染色质调节中的作用。