Pathophysiology and Rehabilitation of Neural Dysfunction

项目摘要 该提案旨在为我们的病理生理学和康复培训计划的第七个周期提供资金 神经功能障碍（PRND）该计划是基于西北大学，在密切合作， Shirley Ryan AbilityLab.它由Eric Perreault博士指导，并由Levi Hargrove博士共同指导， Lee米勒博士和Elliot Roth医学博士。学员将由26名高度协作和富有成效的 来自七个工程和医学系的科学家。该小组具有与下列方面有关的广泛专门知识： 神经功能障碍的病理生理学和康复，范围从细胞神经生理学到 新技术、新材料和新机器的工程设计到临床实施。在这个生命周期中 计划，49名博士前研究员，36名博士后研究员和17名暑期实习生得到了支持 此外，还有200多人从我们的T32活动中受益。大多数受训人员留在学术界， 许多人现在已经成为康复医学领域的领军人物。我们的使命是培养未来的研究人员 从工程学和基础科学中学习，对残疾的基本机制进行研究 神经系统疾病，以指导临床有意义的工具，量化和缓解的发展， 神经系统疾病的严重程度和影响，并继续研究康复干预对 致残性疾病我们的培训从以患者为中心的临床经验开始，从而提供 未来研究的背景。临床经验是由科学的培训补充的机制， 神经功能障碍，从实验室到患者的技术转移信息，以及一些 专业及网络发展活动，为学员在康复服务方面的工作作好准备 科学在这次续约申请中，我们的目标是在过去成就的基础上，通过以下方式提高我们的影响力： 增强功能，将扩大我们接触的科学家社区，完善我们提供的临床经验， 提高我们调查的严谨性，并加强专业发展机会，促进 从实习生到独立科学家我们建议培养三名博士前研究员，三名博士后 研究员和两名暑期实习生。这是一个增加了一个博士后研究员和一个实习生比我们目前的 水平，反映了我们的研究能力的增长。博士预科生将从丰富的人才库中挑选， 申请人在参与工程部门（生物医学，计算机科学，材料科学， 机械）。博士后研究员将从这些相同的部门，并从医学 物理医学与康复系、物理治疗与人体运动科学系，以及 Physiology.所有参与者将完成两年的培训。通过将拟议的创新与 我们期望继续推进康复科学和实践， 通过培养下一代跨学科领导者来培养医学。

Project Summary This proposal seeks funding for the seventh cycle of our training program in Pathophysiology and Rehabilitation of Neural Dysfunction (PRND). The program is based at Northwestern University, in close collaboration with the Shirley Ryan AbilityLab. It is directed by Dr. Eric Perreault, PhD, and co-directed by Drs. Levi Hargrove, PhD, Lee Miller, PhD and Elliot Roth, MD. Trainees will be mentored by 26 highly collaborative and productive scientists from seven departments in engineering and medicine. This group has broad expertise relevant to the pathophysiology and rehabilitation of neural dysfunction, ranging from cellular neurophysiology to the engineering of novel techniques, materials, and machines, to clinical implementation. Over the life of this program, 49 predoctoral fellows, 36 postdoctoral fellows, and 17 summer interns have been supported financially, and more than 200 others have benefitted from our T32 activities. Most trainees remain in academia, and many are now established leaders in rehabilitation medicine. Our mission is to train prospective researchers from engineering and the basic sciences to perform research on fundamental mechanisms underlying disabling neurological illness, to guide the development of clinically meaningful tools for quantifying and relieving the severity and impact of neurologic illness, and to pursue research on the effects of rehabilitation interventions on disabling illnesses. Our training begins with a clinical experience centered on the patient, thereby providing context for future research. The clinical experience is supplemented by scientific training in the mechanisms of neurological dysfunction, information on technology transfer from the laboratory to the patient, and several professional and network development activities to prepare our trainees for a productive career in rehabilitation science. In this renewal application, we aim to build on our past achievements and increase our impact through enhancements that will broaden the community of scientists we reach, refine the clinical experience we provide, increase the rigor of our inquiry, and strengthen the professional development opportunities facilitating the transition from trainee to independent scientist. We propose to train three predoctoral fellows, three postdoctoral fellows and two summer interns. This is an increase of one postdoctoral fellow and one intern over our current levels, reflecting growth in our research capacity. Predoctoral trainees will be selected from the rich pool of applicants in the participating engineering departments (Biomedical, Computer Science, Materials Science, and Mechanical). Postdoctoral fellows will be selected from these same departments, and from the medical departments of Physical Medicine and Rehabilitation, Physical Therapy and Human Movement Sciences, and Physiology. All participants will complete two years of training. By integrating the proposed innovations with the successful practices already in place, we expect to continue advancing the science and practice of rehabilitation medicine by training the next generation of interdisciplinary leaders.